PDB: 221 件ウェブページステータス検索Chemie searchBIRD

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2ZR6	Crystal structure of a mutant PIN1 peptidyl-prolyl cis-trans isomerase 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION 著者 Jobichen, C, Yih-Cherng, L, Sivaraman, J. 登録日 2008-08-22 公開日 2009-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (3.2 Å) 主引用文献 Structural studies on PIN1 mutants To be Published
2ZQS	Crystal structure of a mutant PIN1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION 著者 Jobichen, C, Liou, Y.C, Sivaraman, J. 登録日 2008-08-19 公開日 2009-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (1.902 Å) 主引用文献 Structural studies on PIN1 mutants To be Published
2ZQV	Crystal structure of a mutant PIN1 PEPTIDYL-PROLYL CIS-TRANS ISOMERASE 分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1, SULFATE ION 著者 Jobichen, C, Liou, Y.C, Sivaraman, J. 登録日 2008-08-20 公開日 2009-08-25 最終更新日 2023-11-01 実験手法 X-RAY DIFFRACTION (2.498 Å) 主引用文献 Structural studies on PIN1 mutants To be Published
2Q5A	human Pin1 bound to L-PEPTIDE 分子名称: 3,6,9,12,15,18-HEXAOXAICOSANE, Five residue peptide, Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 著者 Noel, J.P, Zhang, Y. 登録日 2007-05-31 公開日 2007-06-26 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Structural basis for high-affinity peptide inhibition of human Pin1. Acs Chem.Biol., 2, 2007
6AHD	The Cryo-EM Structure of Human Pre-catalytic Spliceosome (B complex) at 3.8 angstrom resolution 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Brr2, U5 small nuclear ribonucleoprotein 200 kDa helicase, ... 著者 Zhan, X, Yan, C, Zhang, X, Shi, Y. 登録日 2018-08-17 公開日 2018-11-14 最終更新日 2021-06-30 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Structures of the human pre-catalytic spliceosome and its precursor spliceosome. Cell Res., 28, 2018
7OQE	Saccharomyces cerevisiae spliceosomal pre-A complex (delta BS-A ACT1) 分子名称: 56 kDa U1 small nuclear ribonucleoprotein component, ACT1 pre-mRNA (delta BS-A), Cold sensitive U2 snRNA suppressor 1, ... 著者 Zhang, Z, Rigo, N, Dybkov, O, Fourmann, J, Will, C.L, Kumar, V, Urlaub, H, Stark, H, Luehrmann, R. 登録日 2021-06-03 公開日 2021-08-11 最終更新日 2021-09-29 実験手法 ELECTRON MICROSCOPY (5.9 Å) 主引用文献 Structural insights into how Prp5 proofreads the pre-mRNA branch site. Nature, 596, 2021
4LCD	Structure of an Rsp5xUbxSna3 complex: Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3 分子名称: E3 ubiquitin-protein ligase RSP5, Protein SNA3, Ubiquitin 著者 Kamadurai, H.B, Miller, D, Schulman, B.A. 登録日 2013-06-21 公開日 2013-08-14 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Mechanism of ubiquitin ligation and lysine prioritization by a HECT E3. Elife, 2, 2013
5O9Z	Cryo-EM structure of a pre-catalytic human spliceosome primed for activation (B complex) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Homo sapiens RNA, U6 small nuclear 1 (RNU6-1), ... 著者 Bertram, K, Kastner, B. 登録日 2017-06-20 公開日 2017-08-16 最終更新日 2018-10-24 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-EM Structure of a Pre-catalytic Human Spliceosome Primed for Activation. Cell, 170, 2017
6PX3	Set2 bound to nucleosome 分子名称: DNA (145-MER), Histone H2B 1.1, Histone H3, ... 著者 Halic, M, Bilokapic, S. 登録日 2019-07-24 公開日 2019-08-28 最終更新日 2019-09-04 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Nucleosome and ubiquitin position Set2 to methylate H3K36. Nat Commun, 10, 2019
8Q7N	cryo-EM structure of the human spliceosomal B complex protomer (tri-snRNP core region) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... 著者 Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. 登録日 2023-08-16 公開日 2024-01-24 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published
8H6L	Cryo-EM structure of human exon-defined spliceosome in the early B state. 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. 登録日 2022-10-18 公開日 2024-05-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.6 Å) 主引用文献 Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
8H6K	Cryo-EM structure of human exon-defined spliceosome in the mature B state. 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Zhang, W, Zhan, X, Zhang, X, Bai, R, Lei, J, Yan, C, Shi, Y. 登録日 2022-10-18 公開日 2024-05-01 最終更新日 2024-06-12 実験手法 ELECTRON MICROSCOPY (2.7 Å) 主引用文献 Structural insights into human exon-defined spliceosome prior to activation. Cell Res., 34, 2024
7ABG	Human pre-Bact-1 spliceosome 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Cell division cycle 5-like protein, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-07 公開日 2020-12-23 最終更新日 2024-05-01 実験手法 ELECTRON MICROSCOPY (7.8 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
6N7P	S. cerevisiae spliceosomal E complex (UBC4) 分子名称: 56 kDa U1 small nuclear ribonucleoprotein component, Nuclear cap-binding protein complex subunit 1, Nuclear cap-binding protein subunit 2, ... 著者 Liu, S, Li, X, Zhou, Z.H, Zhao, R. 登録日 2018-11-27 公開日 2019-09-18 最終更新日 2024-03-20 実験手法 ELECTRON MICROSCOPY (3.6 Å) 主引用文献 A unified mechanism for intron and exon definition and back-splicing. Nature, 573, 2019
6NZO	Set2 bound to nucleosome 分子名称: DNA (149-MER), Histone H2B 1.1, Histone H3, ... 著者 Halic, M, Bilokapic, S. 登録日 2019-02-14 公開日 2019-08-28 最終更新日 2019-09-04 実験手法 ELECTRON MICROSCOPY (3.8 Å) 主引用文献 Nucleosome and ubiquitin position Set2 to methylate H3K36. Nat Commun, 10, 2019
7ABF	Human pre-Bact-1 spliceosome core structure 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, GUANOSINE-5'-TRIPHOSPHATE, INOSITOL HEXAKISPHOSPHATE, ... 著者 Townsend, C, Kastner, B, Leelaram, M.N, Bertram, K, Stark, H, Luehrmann, R. 登録日 2020-09-07 公開日 2020-12-09 最終更新日 2020-12-30 実験手法 ELECTRON MICROSCOPY (3.9 Å) 主引用文献 Mechanism of protein-guided folding of the active site U2/U6 RNA during spliceosome activation. Science, 370, 2020
3OLM	Structure and Function of a Ubiquitin Binding Site within the Catalytic Domain of a HECT Ubiquitin Ligase 分子名称: E3 ubiquitin-protein ligase RSP5, Ubiquitin 著者 Kim, H.C, Steffen, A, Chen, J, Huibregtse, J.M. 登録日 2010-08-26 公開日 2011-03-23 最終更新日 2023-09-06 実験手法 X-RAY DIFFRACTION (2.495 Å) 主引用文献 Structure and function of a HECT domain ubiquitin-binding site. Embo Rep., 12, 2011
7NMZ	Structure of 14-3-3 eta in complex with Nedd4-2(335-455) containing two 14-3-3 binding motifs Ser342 and Ser448 分子名称: 14-3-3 protein eta, E3 ubiquitin-protein ligase NEDD4-like 著者 Pohl, P, Obsil, T, Obsilova, V. 登録日 2021-02-23 公開日 2021-07-21 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.303 Å) 主引用文献 14-3-3-protein regulates Nedd4-2 by modulating interactions between HECT and WW domains. Commun Biol, 4, 2021
8QZS	Cryo-EM structure of the cross-exon B-like complex 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, Microfibrillar-associated protein 1, NHP2-like protein 1, ... 著者 Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. 登録日 2023-10-29 公開日 2024-05-22 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (4.1 Å) 主引用文献 Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
8QPE	Cryo-EM Structure of Pre-B-like Complex (core part) 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, INOSITOL HEXAKISPHOSPHATE, Microfibrillar-associated protein 1, ... 著者 Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Zhong, J, Ludwig, S, Urlaub, H, Kastner, B, Stark, H, Luehrmann, R. 登録日 2023-10-01 公開日 2024-05-22 最終更新日 2024-06-05 実験手法 ELECTRON MICROSCOPY (3.1 Å) 主引用文献 Structural insights into the cross-exon to cross-intron spliceosome switch. Nature, 2024
8QO9	Cryo-EM structure of a human spliceosomal B complex protomer 分子名称: 116 kDa U5 small nuclear ribonucleoprotein component, MINX pre-mRNA, Microfibrillar-associated protein 1, ... 著者 Zhang, Z, Kumar, V, Dybkov, O, Will, C.L, Urlaub, H, Stark, H, Luehrmann, R. 登録日 2023-09-28 公開日 2024-01-24 実験手法 ELECTRON MICROSCOPY (5.29 Å) 主引用文献 New insights into the functions of B complex proteins revealed by cryo-EM of dimerized spliceosomes To Be Published

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