1PI5
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![BU of 1pi5 by Molmil](/molmil-images/mine/1pi5) | Structure of N289A mutant of AmpC in complex with SM2, carboxyphenylglycylboronic acid bearing the cephalothin R1 side chain | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-(3-CARBOXYPHENYL)METHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... | 著者 | Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. | 登録日 | 2003-05-29 | 公開日 | 2004-02-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.49 Å) | 主引用文献 | Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
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1PI4
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![BU of 1pi4 by Molmil](/molmil-images/mine/1pi4) | Structure of N289A mutant of AmpC in complex with SM3, a phenylglyclboronic acid bearing the cephalothin R1 side chain | 分子名称: | (1R)-1-(2-THIENYLACETYLAMINO)-1-PHENYLMETHYLBORONIC ACID, Beta-lactamase, PHOSPHATE ION, ... | 著者 | Roth, T.A, Minasov, G, Focia, P.J, Shoichet, B.K. | 登録日 | 2003-05-29 | 公開日 | 2004-02-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (1.39 Å) | 主引用文献 | Thermodynamic cycle analysis and inhibitor design against beta-lactamase. Biochemistry, 42, 2003
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4OLG
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![BU of 4olg by Molmil](/molmil-images/mine/4olg) | Crystal structure of AmpC beta-lactamase in complex with covalently bound N-formyl 7-aminocephalosporanic acid | 分子名称: | (2R,5Z)-5-[(acetyloxy)methylidene]-2-[(1R)-1-(formylamino)-2-oxoethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Shoichet, B.K, Barelier, S. | 登録日 | 2014-01-23 | 公開日 | 2014-05-28 | 最終更新日 | 2014-06-18 | 実験手法 | X-RAY DIFFRACTION (1.71 Å) | 主引用文献 | Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014
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3SH8
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![BU of 3sh8 by Molmil](/molmil-images/mine/3sh8) | Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cephaloridine | 分子名称: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase | 著者 | Wong, W.-T, Zhao, Y.-X, Leung, Y.-C. | 登録日 | 2011-06-16 | 公開日 | 2011-07-27 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286, 2011
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4OLD
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![BU of 4old by Molmil](/molmil-images/mine/4old) | Crystal structure of AmpC beta-lactamase in complex with the product form of (6R,7R)-7-amino-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid | 分子名称: | (2R)-2-[(R)-amino(carboxy)methyl]-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, Beta-lactamase, PHOSPHATE ION | 著者 | Shoichet, B.K, Barelier, S. | 登録日 | 2014-01-23 | 公開日 | 2014-05-28 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Substrate deconstruction and the nonadditivity of enzyme recognition. J.Am.Chem.Soc., 136, 2014
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4OOY
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![BU of 4ooy by Molmil](/molmil-images/mine/4ooy) | Avibactam and class C beta-lactamases: mechanism of inhibition, conservation of binding pocket and implications for resistance | 分子名称: | (2S,5R)-1-formyl-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Lahiri, S.D, Olivier, N.B, Alm, R.A. | 登録日 | 2014-02-04 | 公開日 | 2014-08-20 | 最終更新日 | 2018-02-14 | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | 主引用文献 | Avibactam and Class C beta-Lactamases: Mechanism of Inhibition, Conservation of the Binding Pocket, and Implications for Resistance. Antimicrob.Agents Chemother., 58, 2014
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4NET
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![BU of 4net by Molmil](/molmil-images/mine/4net) | Crystal structure of ADC-1 beta-lactamase | 分子名称: | AmpC, GLYCEROL, NITRATE ION | 著者 | Bhattacharya, M, Toth, M, Antunes, N.T, Smith, C.A, Vakulenko, S.B. | 登録日 | 2013-10-30 | 公開日 | 2014-03-12 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structure of the extended-spectrum class C beta-lactamase ADC-1 from Acinetobacter baumannii. Acta Crystallogr.,Sect.D, 70, 2014
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4NK3
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![BU of 4nk3 by Molmil](/molmil-images/mine/4nk3) | Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655 | 分子名称: | (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide, Beta-lactamase | 著者 | Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. | 登録日 | 2013-11-12 | 公開日 | 2014-02-19 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin(). Bioorg.Med.Chem.Lett., 24, 2014
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3SOI
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![BU of 3soi by Molmil](/molmil-images/mine/3soi) | Crystallographic structure of Bacillus licheniformis beta-lactamase W210F/W229F/W251F at 1.73 angstrom resolution | 分子名称: | Beta-lactamase, CITRIC ACID | 著者 | Acierno, J.P, Capaldi, S, Risso, V.A, Monaco, H.L, Ermacora, M.R. | 登録日 | 2011-06-30 | 公開日 | 2011-12-14 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (1.729 Å) | 主引用文献 | X-ray evidence of a native state with increased compactness populated by tryptophan-less B. licheniformis beta-lactamase. Protein Sci., 21, 2012
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3SH7
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![BU of 3sh7 by Molmil](/molmil-images/mine/3sh7) | |
4N9K
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![BU of 4n9k by Molmil](/molmil-images/mine/4n9k) | crystal structure of beta-lactamse PenP_E166S in complex with cephaloridine | 分子名称: | 5-METHYL-2-[2-OXO-1-(2-THIOPHEN-2-YL-ACETYLAMINO)-ETHYL]-3,6-DIHYDRO-2H-[1,3]THIAZINE-4-CARBOXYLIC ACID, Beta-lactamase | 著者 | Pan, X, Wong, W, Zhao, Y. | 登録日 | 2013-10-21 | 公開日 | 2014-09-10 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014
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3SH9
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![BU of 3sh9 by Molmil](/molmil-images/mine/3sh9) | Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime | 分子名称: | 1-[6-(dimethylamino)naphthalen-2-yl]ethanone, Beta-lactamase, CEFOTAXIME, ... | 著者 | Wong, W.-T, Zhao, Y.-X, Leung, Y.-C. | 登録日 | 2011-06-16 | 公開日 | 2011-07-27 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics J.Biol.Chem., 286, 2011
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3TG9
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![BU of 3tg9 by Molmil](/molmil-images/mine/3tg9) | The crystal structure of penicillin binding protein from Bacillus halodurans | 分子名称: | Penicillin-binding protein | 著者 | Zhang, Z, Satyanarayana, L, Chamala, S, Evans, B, Foti, R, Gizzi, A, Hillerich, B, Kar, A, LaFleur, J, Seidel, R, Villigas, G, Zencheck, W, Almo, S.C, Swaminathan, S, New York Structural Genomics Research Consortium (NYSGRC) | 登録日 | 2011-08-17 | 公開日 | 2011-08-31 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The crystal structure of penicillin binding protein from Bacillus halodurans To be Published
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3S1Y
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![BU of 3s1y by Molmil](/molmil-images/mine/3s1y) | AMP-C BETA-LACTAMASE (PSEUDOMONAS AERUGINOSA) in complex with a beta-lactamase inhibitor | 分子名称: | Beta-lactamase, CHLORIDE ION, ISOPROPYL ALCOHOL, ... | 著者 | Scapin, G, Lu, J, Fitzgerald, P.M.D, Sharma, N. | 登録日 | 2011-05-16 | 公開日 | 2011-06-29 | 最終更新日 | 2013-06-26 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Side chain SAR of bicyclic Beta-lactamase inhibitors (BLIs). 2. N-Alkylated and open chain analogs of MK-8712 Bioorg.Med.Chem.Lett., 21, 2011
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3S4X
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![BU of 3s4x by Molmil](/molmil-images/mine/3s4x) | |
3VWR
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![BU of 3vwr by Molmil](/molmil-images/mine/3vwr) | Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/R187G/H266N/D370Y mutant complexd with 6-aminohexanoate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
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3VWM
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![BU of 3vwm by Molmil](/molmil-images/mine/3vwm) | Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187A/H266N/D370Y mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
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3VWQ
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![BU of 3vwq by Molmil](/molmil-images/mine/3vwq) | 6-aminohexanoate-dimer hydrolase S112A/G181D/R187A/H266N/D370Y mutant complexd with 6-aminohexanoate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction to be published
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4N92
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![BU of 4n92 by Molmil](/molmil-images/mine/4n92) | |
4OKP
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![BU of 4okp by Molmil](/molmil-images/mine/4okp) | |
4N1H
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![BU of 4n1h by Molmil](/molmil-images/mine/4n1h) | Structure of a single-domain camelid antibody fragment cAb-F11N in complex with the BlaP beta-lactamase from Bacillus licheniformis | 分子名称: | Beta-lactamase, Camelid heavy-chain antibody variable fragment cAb-F11N | 著者 | Pain, C, Kerff, F, Herman, R, Sauvage, E, Preumont, S, Charlier, P, Dumoulin, M. | 登録日 | 2013-10-04 | 公開日 | 2014-10-08 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Probing the mechanism of aggregation of polyQ model proteins with camelid heavy-chain antibody fragments To be Published
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3VWP
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![BU of 3vwp by Molmil](/molmil-images/mine/3vwp) | Crystal structure of 6-aminohexanoate-dimer hydrolase S112A/G181D/R187S/H266N/D370Y mutant complexd with 6-aminohexanoate | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-AMINOHEXANOIC ACID, 6-aminohexanoate-dimer hydrolase, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction to be published
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3VWN
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![BU of 3vwn by Molmil](/molmil-images/mine/3vwn) | Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187G/H266N/D370Y mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
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4N9L
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![BU of 4n9l by Molmil](/molmil-images/mine/4n9l) | crystal structure of beta-lactamse PenP_E166S in complex with meropenem | 分子名称: | (2S,3R,4S)-4-{[(3S,5S)-5-(dimethylcarbamoyl)pyrrolidin-3-yl]sulfanyl}-2-[(2S,3R)-3-hydroxy-1-oxobutan-2-yl]-3-methyl-3,4-dihydro-2H-pyrrole-5-carboxylic acid, Beta-lactamase | 著者 | Pan, X, Wong, W, Zhao, Y. | 登録日 | 2013-10-21 | 公開日 | 2014-09-10 | 最終更新日 | 2022-02-09 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Perturbing the General Base Residue Glu166 in the Active Site of Class A beta-Lactamase Leads to Enhanced Carbapenem Binding and Acylation Biochemistry, 53, 2014
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3VWL
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![BU of 3vwl by Molmil](/molmil-images/mine/3vwl) | Crystal structure of 6-aminohexanoate-dimer hydrolase G181D/R187S/H266N/D370Y mutant | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 6-aminohexanoate-dimer hydrolase, GLYCEROL, ... | 著者 | Kawashima, Y, Shibata, N, Negoro, S, Higuchi, Y. | 登録日 | 2012-08-30 | 公開日 | 2013-10-16 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structural, kinetic and theoretical analyses of hydrolase mutants altering in the directionality and equilibrium point of reversible amide-synthetic/hydrolytic reaction To be Published
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