4OLG

Crystal structure of AmpC beta-lactamase in complex with covalently bound N-formyl 7-aminocephalosporanic acid

Summary for 4OLG

• Entry DOI: 10.2210/pdb4olg/pdb
• Related: 1kvl 1kvm
• Descriptor: Beta-lactamase, (2R,5Z)-5-[(acetyloxy)methylidene]-2-[(1R)-1-(formylamino)-2-oxoethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
• Functional Keywords: ampc beta-lactamase, class, cephalosporinase, hydrolase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79871.39

Authors

Shoichet, B.K.,Barelier, S. (deposition date: 2014-01-23, release date: 2014-05-28, Last modification date: 2014-06-18)

• Primary citation: Barelier, S.,Cummings, J.A.,Rauwerdink, A.M.,Hitchcock, D.S.,Farelli, J.D.,Almo, S.C.,Raushel, F.M.,Allen, K.N.,Shoichet, B.K.; Substrate deconstruction and the nonadditivity of enzyme recognition.; J.Am.Chem.Soc., 136:7374-7382, 2014; PubMed: 24791931; DOI: 10.1021/ja501354q

Experimental method

X-RAY DIFFRACTION (1.71 Å)