Crystal structure of AmpC beta-lactamase in complex with covalently bound N-formyl 7-aminocephalosporanic acid

Summary for 4OLG

Related1kvl 1kvm
DescriptorBeta-lactamase, (2R,5Z)-5-[(acetyloxy)methylidene]-2-[(1R)-1-(formylamino)-2-oxoethyl]-5,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, PHOSPHATE ION, ... (4 entities in total)
Functional Keywordsampc beta-lactamase, class, cephalosporinase, hydrolase
Biological sourceEscherichia coli
Cellular locationPeriplasm P00811
Total number of polymer chains2
Total molecular weight79871.39
Shoichet, B.K.,Barelier, S. (deposition date: 2014-01-23, release date: 2014-05-28, Last modification date: 2014-06-18)
Primary citation
Barelier, S.,Cummings, J.A.,Rauwerdink, A.M.,Hitchcock, D.S.,Farelli, J.D.,Almo, S.C.,Raushel, F.M.,Allen, K.N.,Shoichet, B.K.
Substrate deconstruction and the nonadditivity of enzyme recognition.
J.Am.Chem.Soc., 136:7374-7382, 2014
PubMed: 24791931 (PDB entries with the same primary citation)
DOI: 10.1021/ja501354q
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.202501.6%3.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution

More Asymmetric unit images

Molmil generated image of 4olg
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Molmil generated image of 4olg
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Molmil generated image of 4olg
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