4OKP

Crystal structure of AmpC beta-lactamase in complex with the product form of 7-amino-desacetoxycephalosporanic acid

Summary for 4OKP

• Entry DOI: 10.2210/pdb4okp/pdb
• Related: 1kvl 1kvm 4OLD
• Descriptor: Beta-lactamase, PHOSPHATE ION, (2R)-2-[(R)-amino(carboxy)methyl]-5-methyl-3,6-dihydro-2H-1,3-thiazine-4-carboxylic acid, ... (4 entities in total)
• Functional Keywords: ampc beta-lactamase, class c, hydrolase, cephalosporinase
• Biological source: Escherichia coli
• Cellular location: Periplasm: P00811
• Total number of polymer chains: 2
• Total formula weight: 79598.04

Authors

Barelier, S.B.,Shoichet, B.K. (deposition date: 2014-01-22, release date: 2014-05-28, Last modification date: 2024-02-28)

• Primary citation: Barelier, S.,Cummings, J.A.,Rauwerdink, A.M.,Hitchcock, D.S.,Farelli, J.D.,Almo, S.C.,Raushel, F.M.,Allen, K.N.,Shoichet, B.K.; Substrate deconstruction and the nonadditivity of enzyme recognition.; J.Am.Chem.Soc., 136:7374-7382, 2014; PubMed: 24791931; DOI: 10.1021/ja501354q

Experimental method

X-RAY DIFFRACTION (1.37 Å)