3SH9

Crystal structure of fluorophore-labeled beta-lactamase PenP in complex with cefotaxime

Replaces:  3KGN

Summary for 3SH9

• Entry DOI: 10.2210/pdb3sh9/pdb
• Related: 3SH7 3SH8
• Descriptor: Beta-lactamase, CEFOTAXIME, C3' cleaved, open, bound form, 1-[6-(dimethylamino)naphthalen-2-yl]ethanone, ... (4 entities in total)
• Functional Keywords: penp, beta-lactamase, cefotaxime, fluorophore, hydrolase-antibiotic complex, hydrolase/antibiotic
• Biological source: Bacillus licheniformis
• Total number of polymer chains: 2
• Total formula weight: 60516.73

Authors

Wong, W.-T.,Zhao, Y.-X.,Leung, Y.-C. (deposition date: 2011-06-16, release date: 2011-07-27, Last modification date: 2023-11-01)

• Primary citation: Wong, W.-T.,Chan, K.-C.,So, P.-K.,Yap, H.-K.,Chung, W.-H.,Leung, Y.-C.,Wong, K.-Y.,Zhao, Y.-X.; Increased structural flexibility at the active site of a fluorophore-conjugated beta-lactamase distinctively impacts its binding toward diverse cephalosporin antibiotics; J.Biol.Chem., 286:31771-31780, 2011; PubMed: 21705325; DOI: 10.1074/jbc.M110.198895

Experimental method

X-RAY DIFFRACTION (1.9 Å)