4NK3

Amp-c beta-lactamase (pseudomonas aeruginosa) in complex with mk-7655

Summary for 4NK3

Entry DOI	10.2210/pdb4nk3/pdb
Descriptor	Beta-lactamase, (2S,5R)-1-formyl-N-(piperidin-4-yl)-5-[(sulfooxy)amino]piperidine-2-carboxamide (3 entities in total)
Functional Keywords	hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
Biological source	Pseudomonas aeruginosa
Cellular location	Periplasm (By similarity): P24735
Total number of polymer chains	1
Total formula weight	41374.71
Authors	Scapin, G.,Lu, J.,Fitzgerald, P.M.D.,Sharma, N. (deposition date: 2013-11-12, release date: 2014-02-19)
Primary citation	Blizzard, T.A.,Chen, H.,Kim, S.,Wu, J.,Bodner, R.,Gude, C.,Imbriglio, J.,Young, K.,Park, Y.W.,Ogawa, A.,Raghoobar, S.,Hairston, N.,Painter, R.E.,Wisniewski, D.,Scapin, G.,Fitzgerald, P.,Sharma, N.,Lu, J.,Ha, S.,Hermes, J.,Hammond, M.L. Discovery of MK-7655, a beta-lactamase inhibitor for combination with Primaxin(). Bioorg.Med.Chem.Lett., 24:780-785, 2014 Cited by PubMed: 24433862 DOI: 10.1016/j.bmcl.2013.12.101 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation