8FCA
| Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate | 分子名称: | (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4 | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.41 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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7L2L
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7MIM
| Mouse TRPV3 in cNW11 nanodiscs, closed state at 4 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Neuberger, A, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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7MZE
| Cryo-EM structure of minimal TRPV1 with 2 bound RTX in opposite pockets | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2021-05-24 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.42 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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5IS0
| Structure of TRPV1 in complex with capsazepine, determined in lipid nanodisc | 分子名称: | Transient receptor potential cation channel subfamily V member 1, capsazepine | 著者 | Gao, Y, Cao, E, Julius, D, Cheng, Y. | 登録日 | 2016-03-15 | 公開日 | 2016-05-25 | 最終更新日 | 2024-03-06 | 実験手法 | ELECTRON MICROSCOPY (3.43 Å) | 主引用文献 | TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action. Nature, 534, 2016
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8JVJ
| Structure of human TRPV4 with antagonist A2 and RhoA | 分子名称: | Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4,3C-GFP, [6-[[4-(2,4-dimethyl-1,3-thiazol-5-yl)-1,3-thiazol-2-yl]amino]pyridin-3-yl]-[(1~{S},5~{R})-3-[5-(trifluoromethyl)pyrimidin-2-yl]-3,8-diazabicyclo[3.2.1]octan-8-yl]methanone | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-28 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.44 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
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8JU6
| Structure of human TRPV4 with antagonist GSK279 | 分子名称: | 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, Transient receptor potential cation channel subfamily V member 4,3C-GFP | 著者 | Fan, J, Lei, X. | 登録日 | 2023-06-24 | 公開日 | 2024-05-08 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Structural Pharmacology of TRPV4 Antagonists. Adv Sci, 2024
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7RQV
| Cryo-EM structure of the full-length TRPV1 with RTx at 4 degrees Celsius, in an intermediate-closed state, class II | 分子名称: | 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Kwon, D.H, Suo, Y, Lee, S.-Y. | 登録日 | 2021-08-08 | 公開日 | 2022-06-01 | 実験手法 | ELECTRON MICROSCOPY (3.45 Å) | 主引用文献 | Vanilloid-dependent TRPV1 opening trajectory from cryoEM ensemble analysis. Nat Commun, 13, 2022
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7MZA
| Cryo-EM structure of minimal TRPV1 with 2 bound RTX in adjacent pockets | 分子名称: | (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2021-05-24 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.46 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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7L2U
| cryo-EM structure of DkTx-bound minimal TRPV1 in open state | 分子名称: | (11R,14S)-17-amino-14-hydroxy-8,14-dioxo-9,13,15-trioxa-14lambda~5~-phosphaheptadecan-11-yl decanoate, (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2R,3S,4S,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate, SODIUM ION, ... | 著者 | Zhang, K, Julius, D, Cheng, Y. | 登録日 | 2020-12-17 | 公開日 | 2021-09-22 | 最終更新日 | 2021-10-13 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | Structural snapshots of TRPV1 reveal mechanism of polymodal functionality. Cell, 184, 2021
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8FC8
| Cryo-EM structure of the human TRPV4 in complex with GSK1016790A | 分子名称: | CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4 | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.47 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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7MIO
| Mouse TRPV3 in cNW11 nanodiscs, open state at 42 degrees Celsius | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, SODIUM ION, Transient receptor potential cation channel subfamily V member 3 | 著者 | Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2021-04-17 | 公開日 | 2021-07-21 | 最終更新日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | 主引用文献 | Structural mechanism of heat-induced opening of a temperature-sensitive TRP channel. Nat.Struct.Mol.Biol., 28, 2021
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8T1C
| Cryo-EM structure of human TRPV4 ankyrin repeat domain in complex with GTPase RhoA | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, Transforming protein RhoA, Transient receptor potential cation channel subfamily V member 4-Enhanced green fluorescent protein chimera | 著者 | Nadezhdin, K.D, Talyzina, I.A, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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8T1F
| Cryo-EM structure of full-length human TRPV4 in complex with antagonist HC-067047 | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-methyl-1-[3-(morpholin-4-yl)propyl]-5-phenyl-N-[3-(trifluoromethyl)phenyl]-1H-pyrrole-3-carboxamide, Transient receptor potential cation channel subfamily V member 4/Enhanced green fluorescent protein chimera | 著者 | Talyzina, I.A, Nadezhdin, K.D, Neuberger, A, Sobolevsky, A.I. | 登録日 | 2023-06-02 | 公開日 | 2023-07-05 | 実験手法 | ELECTRON MICROSCOPY (3.49 Å) | 主引用文献 | Structure of human TRPV4 in complex with GTPase RhoA. Nat Commun, 14, 2023
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4RLV
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8JEU
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8T0Y
| TRPV1 in nanodisc bound with one LPA in one monomer | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, (2R)-3-{[(R)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propane-1,2-diyl dioctadecanoate, SODIUM ION, ... | 著者 | Arnold, W.R, Cheng, Y. | 登録日 | 2023-06-01 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8FFO
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8T3M
| TRPV1 in nanodisc bound with 3 LPA molecules | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl tetradecanoate, SODIUM ION, Transient receptor potential cation channel subfamily V member 1, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-06-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8T0C
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6MHV
| Structure of human TRPV3 in the presence of 2-APB in C4 symmetry | 分子名称: | Transient receptor potential cation channel subfamily V member 3 | 著者 | Zubcevic, L, Herzik, M.A, Wu, M, Borschel, W.F, Hirschi, M, Song, A, Lander, G.C, Lee, S.Y. | 登録日 | 2018-09-18 | 公開日 | 2018-10-03 | 最終更新日 | 2024-03-13 | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | 主引用文献 | Conformational ensemble of the human TRPV3 ion channel. Nat Commun, 9, 2018
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5H2C
| Crystal structure of Saccharomyces cerevisiae Osh1 ANK - Nvj1 | 分子名称: | Nucleus-vacuole junction protein 1, Oxysterol-binding protein homolog 1 | 著者 | Im, Y.J, Manik, M.K, Yang, H.S, Tong, J.S. | 登録日 | 2016-10-14 | 公開日 | 2017-05-10 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (3.508 Å) | 主引用文献 | Structure of Yeast OSBP-Related Protein Osh1 Reveals Key Determinants for Lipid Transport and Protein Targeting at the Nucleus-Vacuole Junction Structure, 25, 2017
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8FCB
| Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK1016790A | 分子名称: | 5'-GUANOSINE-DIPHOSPHATE-MONOTHIOPHOSPHATE, CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, ... | 著者 | Kwon, D.H, Lee, S.-Y, Zhang, F. | 登録日 | 2022-12-01 | 公開日 | 2023-07-12 | 実験手法 | ELECTRON MICROSCOPY (3.52 Å) | 主引用文献 | TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease. Nat Commun, 14, 2023
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7LPB
| Cryo-EM structure of full-length TRPV1 with capsaicin at 25 degrees Celsius | 分子名称: | (6E)-N-(4-hydroxy-3-methoxybenzyl)-8-methylnon-6-enamide, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphoglycerol, ... | 著者 | Kwon, D.H, Zhang, F, Suo, Y, Lee, S.-Y. | 登録日 | 2021-02-11 | 公開日 | 2021-07-28 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Heat-dependent opening of TRPV1 in the presence of capsaicin. Nat.Struct.Mol.Biol., 28, 2021
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7XJ3
| Structure of human TRPV3 | 分子名称: | [(2~{R})-1-[2-azanylethoxy(oxidanyl)phosphoryl]oxy-3-hexadecanoyloxy-propan-2-yl] (~{Z})-octadec-9-enoate, fusion of transient receptor potential cation channel subfamily V member 3 and 3C-GFP | 著者 | Fan, J, Yue, Z, Jiang, D, Lei, X. | 登録日 | 2022-04-14 | 公開日 | 2022-11-09 | 最終更新日 | 2023-01-11 | 実験手法 | ELECTRON MICROSCOPY (3.54 Å) | 主引用文献 | Structural basis of TRPV3 inhibition by an antagonist. Nat.Chem.Biol., 19, 2023
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