PDB: 2561 件ウェブページステータス検索Chemie searchBIRD

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3PN1	Novel Bacterial NAD+-dependent DNA Ligase Inhibitors with Broad Spectrum Potency and Antibacterial Efficacy In Vivo 分子名称: 1-(2,4-dimethylbenzyl)-6-oxo-1,6-dihydropyridine-3-carboxamide, 2-(butylsulfanyl)adenosine, DNA ligase 著者 Mills, S, Eakin, A, Buurman, E, Newman, J, Gao, N, Huynh, H, Johnson, K, Lahiri, S, Shapiro, A, Walkup, G, Wei, Y, Stokes, S. 登録日 2010-11-18 公開日 2011-01-12 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Novel Bacterial NAD+-Dependent DNA Ligase Inhibitors with Broad-Spectrum Activity and Antibacterial Efficacy In Vivo. Antimicrob.Agents Chemother., 55, 2011
3NL3	The Crystal Structure of Candida glabrata THI6, a Bifunctional Enzyme involved in Thiamin Biosyhthesis of Eukaryotes 分子名称: MAGNESIUM ION, THIAMIN PHOSPHATE, Thiamine biosynthetic bifunctional enzyme 著者 Paul, D, Chatterjee, A, Begley, T.P, Ealick, S.E. 登録日 2010-06-21 公開日 2010-11-10 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (3.007 Å) 主引用文献 Domain Organization in Candida glabrata THI6, a Bifunctional Enzyme Required for Thiamin Biosynthesis in Eukaryotes . Biochemistry, 49, 2010
6SHN	Escherichia coli AGPase in complex with FBP. Symmetry C1 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Glucose-1-phosphate adenylyltransferase 著者 Cifuente, J.O, Comino, N, D'Angelo, C, Marina, A, Gil-Carton, D, Albesa-Jove, D, Guerin, M.E. 登録日 2019-08-07 公開日 2020-02-05 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.3 Å) 主引用文献 The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM. Curr Res Struct Biol, 2, 2020
6SHJ	Escherichia coli AGPase in complex with FBP. Symmetry applied C2 分子名称: 1,6-di-O-phosphono-beta-D-fructofuranose, Glucose-1-phosphate adenylyltransferase 著者 Cifuente, J.O, Comino, N, D'Angelo, C, Marina, A, Gil-Carton, D, Albesa-Jove, D, Guerin, M.E. 登録日 2019-08-07 公開日 2020-02-05 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM. Curr Res Struct Biol, 2, 2020
6SHQ	Escherichia coli AGPase in complex with AMP. Symmetry C2 分子名称: ADENOSINE MONOPHOSPHATE, Glucose-1-phosphate adenylyltransferase 著者 Cifuente, J.O, Comino, N, D'Angelo, C, Marina, A, Gil-Carton, D, Albesa-Jove, D, Guerin, M.E. 登録日 2019-08-07 公開日 2020-02-05 最終更新日 2024-05-22 実験手法 ELECTRON MICROSCOPY (3.2 Å) 主引用文献 The allosteric control mechanism of bacterial glycogen biosynthesis disclosed by cryoEM. Curr Res Struct Biol, 2, 2020
8JBR	Structure of McyA2-CAPCP 分子名称: 4'-PHOSPHOPANTETHEINE, ADENOSINE-5'-TRIPHOSPHATE, McyA protein 著者 Peng, Y.J. 登録日 2023-05-09 公開日 2024-01-24 最終更新日 2024-07-03 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Modular catalytic activity of nonribosomal peptide synthetases depends on the dynamic interaction between adenylation and condensation domains. Structure, 32, 2024
8GJY	Structure of a cGAS-like receptor Sp-cGLR1 from S. pistillata 分子名称: cGAS-like receptor 1 著者 Li, Y, Toyoda, H, Slavik, K.M, Morehouse, B.R, Kranzusch, P.J. 登録日 2023-03-16 公開日 2023-07-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 cGLRs are a diverse family of pattern recognition receptors in innate immunity. Cell, 186, 2023
7AG4	Crystal structure of active site mutant of SQ Isomerase (YihS-H248A) from Salmonella enterica in complex with sulfofructose (SF) 分子名称: 6-deoxy-6-sulfo-D-fructose, Sulfoquinovose isomerase 著者 Sharma, M, Davies, G.J. 登録日 2020-09-21 公開日 2021-04-14 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 Molecular Basis of Sulfosugar Selectivity in Sulfoglycolysis. Acs Cent.Sci., 7, 2021
7FG6	Crystal structure of the Tyrosyl-tRNA synthetase (TyrRS) in Nanoarchaeum equitans 分子名称: Tyrosine--tRNA ligase 著者 Noguchi, H, Kamata, K, Park, S.Y, Tamura, K. 登録日 2021-07-26 公開日 2021-09-08 最終更新日 2023-11-29 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Crystal structure of Nanoarchaeum equitans tyrosyl-tRNA synthetase and its aminoacylation activity toward tRNA Tyr with an extra guanosine residue at the 5'-terminus. Biochem.Biophys.Res.Commun., 575, 2021
3RG2	Structure of a two-domain NRPS fusion protein containing the EntE adenylation domain and EntB aryl-carrier protein from enterobactin biosynthesis 分子名称: 4'-PHOSPHOPANTETHEINE, 5'-deoxy-5'-({[2-(2-hydroxyphenyl)ethyl]sulfonyl}amino)adenosine, Enterobactin synthase component E (entE), ... 著者 Sundlov, J.A, Gulick, A.M. 登録日 2011-04-07 公開日 2012-03-07 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Structural and Functional Investigation of the Intermolecular Interaction between NRPS Adenylation and Carrier Protein Domains. Chem.Biol., 19, 2012
5Z9R	NMNAT as a specific chaperone antagonizing pathological condensation of phosphorylated tau 分子名称: Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 3 著者 Dou, S, Ma, X, Li, D, Liu, C. 登録日 2018-02-05 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Nicotinamide mononucleotide adenylyltransferase uses its NAD+substrate-binding site to chaperone phosphorylated Tau. Elife, 9, 2020
7LJN	Structure of the Bradyrhizobium diazoefficiens CD-NTase CdnG in complex with GTP 分子名称: CD-NTase, GUANOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION 著者 Govande, A, Lowey, B, Eaglesham, J.B, Whiteley, A.T, Kranzusch, P.J. 登録日 2021-01-29 公開日 2021-06-02 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (1.6 Å) 主引用文献 Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense. Cell Rep, 35, 2021
7MGQ	AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans 分子名称: 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase, MAGNESIUM ION 著者 Wizrah, M.S, Chua, S.M.H, Luo, Z, Manik, M.K, Pan, M, Whyte, J.M, Robertson, A.B, Kappler, U, Kobe, B, Fraser, J.A. 登録日 2021-04-13 公開日 2022-04-20 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.67 Å) 主引用文献 AICAR transformylase/IMP cyclohydrolase (ATIC) is essential for de novo purine biosynthesis and infection by Cryptococcus neoformans. J.Biol.Chem., 298, 2022
5U2M	Crystal structure of human NAMPT with A-1293201 分子名称: N-[4-({[(3S)-oxolan-3-yl]methyl}carbamoyl)phenyl]-1,3-dihydro-2H-isoindole-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION 著者 Longenecker, K.L, Raich, D, Korepanova, A.V. 登録日 2016-11-30 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
5U2N	Crystal structure of human NAMPT with A-1326133 分子名称: N-{4-[1-(2-methylpropanoyl)piperidin-4-yl]phenyl}-2H-pyrrolo[3,4-c]pyridine-2-carboxamide, Nicotinamide phosphoribosyltransferase, SULFATE ION 著者 Longenecker, K.L, Raich, D, Korepanova, A.V. 登録日 2016-11-30 公開日 2017-06-28 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.73 Å) 主引用文献 Discovery and Characterization of Novel Nonsubstrate and Substrate NAMPT Inhibitors. Mol. Cancer Ther., 16, 2017
2X93	Crystal structure of AnCE-trandolaprilat complex 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ANGIOTENSIN CONVERTING ENZYME, ... 著者 Akif, M, Georgiadis, D, Mahajan, A, Dive, V, Sturrock, E.D, Isaac, R.E, Acharya, K.R. 登録日 2010-03-14 公開日 2010-06-02 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (1.98 Å) 主引用文献 High Resolution Crystal Structures of Drosophila Melanogaster Angiotensin Converting Enzyme in Complex with Novel Inhibitors and Anti- Hypertensive Drugs. J.Mol.Biol., 400, 2010
2C7I	Structure of protein Ta0514, putative lipoate protein ligase from T. acidophilum. 分子名称: PUTATIVE LIPOATE PROTEIN LIGASE 著者 Mcmanus, E, Perham, R.N, Luisi, B.F. 登録日 2005-11-24 公開日 2005-12-15 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure of a Putative Lipoate Protein Ligase from Thermoplasma Acidophilum and the Mechanism of Target Selection for Post-Translational Modification. J.Mol.Biol., 356, 2006
4OU1	Crystal structure of a computationally designed retro-aldolase covalently bound to folding probe 1 [(6-methoxynaphthalen-2-yl)(oxiran-2-yl)methanol] 分子名称: (1S,2S)-1-(6-methoxynaphthalen-2-yl)propane-1,2-diol, BENZOIC ACID, PHOSPHATE ION, ... 著者 Bhabha, G, Zhang, X, Ekiert, D.C. 登録日 2014-02-14 公開日 2014-03-05 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.25 Å) 主引用文献 Small molecule probes to quantify the functional fraction of a specific protein in a cell with minimal folding equilibrium shifts. Proc.Natl.Acad.Sci.USA, 111, 2014
2QG9	Structure of a regulatory subunit mutant D19A of ATCase from E. coli 分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION 著者 Stec, B, Williams, M.K, Stieglitz, K.A, Kantrowitz, E.R. 登録日 2007-06-28 公開日 2008-02-19 最終更新日 2024-02-21 実験手法 X-RAY DIFFRACTION (2.7 Å) 主引用文献 Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors. Acta Crystallogr.,Sect.D, 63, 2007
2QGF	Structure of regulatory chain mutant H20A of asparate transcarbamoylase from E. coli 分子名称: Aspartate carbamoyltransferase catalytic chain, Aspartate carbamoyltransferase regulatory chain, ZINC ION 著者 Stec, B, Williams, M.K, Stieglitz, K.A, Kantrowitz, E.R. 登録日 2007-06-28 公開日 2008-02-19 最終更新日 2023-08-30 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Comparison of two T-state structures of regulatory-chain mutants of Escherichia coli aspartate transcarbamoylase suggests that His20 and Asp19 modulate the response to heterotropic effectors. Acta Crystallogr.,Sect.D, 63, 2007
2R6I	Crystal structure of Atu1473 protein, a putative chaperone from Agrobacterium tumefaciens 分子名称: Uncharacterized protein Atu1473 著者 Osipiuk, J, Xu, X, Zheng, H, Savchenko, A, Edwards, A.M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2007-09-05 公開日 2007-09-18 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.59 Å) 主引用文献 Crystal structure of Atu1473 protein, a putative chaperone from Agrobacterium tumefaciens. To be Published
3WUH	Qri7 and AMP complex 分子名称: ADENOSINE MONOPHOSPHATE, ZINC ION, tRNA N6-adenosine threonylcarbamoyltransferase, ... 著者 Tominaga, T, Kobayashi, K, Ishii, R, Ishitani, R, Nureki, O. 登録日 2014-04-24 公開日 2014-09-17 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.937 Å) 主引用文献 Structure of Saccharomyces cerevisiae mitochondrial Qri7 in complex with AMP ACTA CRYSTALLOGR.,SECT.F, 70, 2014
2C8M	Structure of protein Ta0514, putative lipoate protein ligase from T. acidophilum with bound lipoic acid 分子名称: LIPOATE-PROTEIN LIGASE A, LIPOIC ACID 著者 McManus, E, Perham, R.N, Luisi, B.F. 登録日 2005-12-06 公開日 2005-12-15 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.89 Å) 主引用文献 Structure of a Putative Lipoate Protein Ligase from Thermoplasma Acidophilum and the Mechanism of Target Selection for Post-Translational Modification. J.Mol.Biol., 356, 2006
1YIA	Crystal structure of tryptophanyl tRNA synthetase II from Deinococcus radiodurans in complex with 5-Hydroxy tryptophan. 分子名称: 5-HYDROXY-L-TRYPTOPHAN, tryptophanyl-tRNA synthetase 著者 Buddha, M.R, Crane, B.R. 登録日 2005-01-11 公開日 2005-02-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (3.7 Å) 主引用文献 Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan. Nat.Struct.Mol.Biol., 12, 2005
1YI8	Crystal structure of tryptophanyl trRNA synthetase II from Deinococcus radiodurans in complex with L-Trp 分子名称: TRYPTOPHAN, tryptophanyl-tRNA synthetase 著者 Buddha, M.R, Crane, B.R. 登録日 2005-01-11 公開日 2005-02-22 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure and activity of an aminoacyl-tRNA synthetase that charges tRNA with nitro-tryptophan. Nat.Struct.Mol.Biol., 12, 2005

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