1M1G
| Crystal Structure of Aquifex aeolicus N-utilization substance G (NusG), Space Group P2(1) | 分子名称: | Transcription antitermination protein nusG | 著者 | Steiner, T, Kaiser, J.T, Marinkovic, S, Huber, R, Wahl, M.C. | 登録日 | 2002-06-19 | 公開日 | 2003-02-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structures of transcription factor NusG in light of its nucleic
acid- and protein-binding activities Embo J., 21, 2002
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1M1H
| Crystal structure of Aquifex aeolicus N-utilization substance G (NusG), Space group I222 | 分子名称: | Transcription antitermination protein nusG | 著者 | Steiner, T, Kaiser, J.T, Marinkovic, S, Huber, R, Wahl, M.C. | 登録日 | 2002-06-19 | 公開日 | 2003-02-04 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Crystal structures of transcription factor NusG in light of its nucleic acid- and protein-binding activities Embo J., 21, 2002
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4V5C
| Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A-site tRNA, deacylated P-site tRNA, and E-site tRNA. | 分子名称: | 16S ribosomal RNA, 23S Ribosomal RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Voorhees, R.M, Weixlbaumer, A, Loakes, D, Kelley, A.C, Ramakrishnan, V. | 登録日 | 2009-03-24 | 公開日 | 2014-07-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | Insights Into Substrate Stabilization from Snapshots of the Peptidyl Transferase Center of the Intact 70S Ribosome Nat.Struct.Mol.Biol., 16, 2009
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4V5D
| Structure of the Thermus thermophilus 70S ribosome in complex with mRNA, paromomycin, acylated A- and P-site tRNAs, and E-site tRNA. | 分子名称: | 16S ribosomal RNA, 23S RIBOSOMAL RNA, 30S RIBOSOMAL PROTEIN S10, ... | 著者 | Voorhees, R.M, Weixlbaumer, A, Loakes, D, Kelley, A.C, Ramakrishnan, V. | 登録日 | 2009-03-24 | 公開日 | 2014-07-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (3.5 Å) | 主引用文献 | Insights into substrate stabilization from snapshots of the peptidyl transferase center of the intact 70S ribosome. Nat. Struct. Mol. Biol., 16, 2009
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9EMC
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8CYI
| Cryo-EM structures and computational analysis for enhanced potency in MTA-synergic inhibition of human protein arginine methyltransferase 5 | 分子名称: | 5'-DEOXY-5'-METHYLTHIOADENOSINE, Methylosome protein 50, N-[(2-aminoquinolin-7-yl)methyl]-9-(2-hydroxyethyl)-2,3,4,9-tetrahydro-1H-carbazole-6-carboxamide, ... | 著者 | Yadav, G.P, Wei, Z, Xiaozhi, Y, Chenglong, L, Jiang, Q. | 登録日 | 2022-05-23 | 公開日 | 2023-04-12 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | Cryo-EM structure-based selection of computed ligand poses enables design of MTA-synergic PRMT5 inhibitors of better potency. Commun Biol, 5, 2022
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9BDN
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9BDP
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9BDL
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5LYB
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6JXV
| SUMO1 bound to phosphorylated SLS4-SIM peptide from ICP0 | 分子名称: | Phosphorylated SLS4-SIM from ubiquitin E3 ligase ICP0, Small ubiquitin-related modifier | 著者 | Hembram, D.S.S, Negi, H, Shet, D, Das, R. | 登録日 | 2019-04-25 | 公開日 | 2020-02-05 | 最終更新日 | 2023-06-14 | 実験手法 | SOLUTION NMR | 主引用文献 | The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2. J.Mol.Biol., 432, 2020
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6JXU
| SUMO1 bound to SLS4-SIM peptide from ICP0 | 分子名称: | Small ubiquitin-related modifier, viral protein | 著者 | Hembram, D.S.S, Negi, H, Shet, D, Das, R. | 登録日 | 2019-04-25 | 公開日 | 2020-02-05 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | The Viral SUMO-Targeted Ubiquitin Ligase ICP0 is Phosphorylated and Activated by Host Kinase Chk2. J.Mol.Biol., 432, 2020
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3KZ3
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5WM9
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2FQ4
| The crystal structure of the transcriptional regulator (TetR family) from Bacillus cereus | 分子名称: | Transcriptional regulator, TetR family | 著者 | Zhang, R, Wu, R, Moy, S, Cymborowski, M, Minor, W, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2006-01-17 | 公開日 | 2006-02-28 | 最終更新日 | 2022-04-13 | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | 主引用文献 | The crystal structure of the transcriptional regulator (TetR family) from Bacillus cereus To be Published
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2G9A
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5WJJ
| Structure-based Design, Synthesis, and Biological Evaluation of Imidazo[1,2-b]pyridazine-based p38 MAP Kinase Inhibitors | 分子名称: | Mitogen-activated protein kinase 14, N-{4-[2-(4-fluoro-3-methylphenyl)imidazo[1,2-b]pyridazin-3-yl]pyridin-2-yl}-2-methyl-1-oxo-1lambda~5~-pyridine-4-carboxamide | 著者 | Snell, G.P, Okada, K, Bragstad, K, Sang, B.-C. | 登録日 | 2017-07-23 | 公開日 | 2018-01-17 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Structure-based design, synthesis, and biological evaluation of imidazo[1,2-b]pyridazine-based p38 MAP kinase inhibitors. Bioorg. Med. Chem., 26, 2018
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4V2F
| Tetracycline repressor TetR(D), unliganded | 分子名称: | TETRACYCLINE REPRESSOR PROTEIN CLASS D | 著者 | Werten, S, Orth, P, Saenger, W, Hinrichs, W. | 登録日 | 2014-10-09 | 公開日 | 2014-12-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Tetracycline Repressor Allostery Does not Depend on Divalent Metal Recognition. Biochemistry, 53, 2014
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4V2G
| Tetracycline repressor TetR(D) bound to chlortetracycline and iso- chlortetracycline | 分子名称: | 7-CHLOROTETRACYCLINE, ISO-7-CHLORTETRACYCLINE, MAGNESIUM ION, ... | 著者 | Werten, S, Orth, P, Saenger, W, Hinrichs, W. | 登録日 | 2014-10-09 | 公開日 | 2014-12-10 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.71 Å) | 主引用文献 | Tetracycline Repressor Allostery Does not Depend on Divalent Metal Recognition. Biochemistry, 53, 2014
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7QP7
| Structure of the human 48S initiation complex in closed state (h48S AUG closed) | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | 登録日 | 2022-01-03 | 公開日 | 2022-05-11 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
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7QP6
| Structure of the human 48S initiation complex in open state (h48S AUG open) | 分子名称: | 18S rRNA, 40S ribosomal protein S10, 40S ribosomal protein S11, ... | 著者 | Yi, S.-H, Petrychenko, V, Schliep, J.E, Goyal, A, Linden, A, Chari, A, Urlaub, H, Stark, H, Rodnina, M.V, Adio, S, Fischer, N. | 登録日 | 2022-01-03 | 公開日 | 2022-05-11 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (4.7 Å) | 主引用文献 | Conformational rearrangements upon start codon recognition in human 48S translation initiation complex. Nucleic Acids Res., 50, 2022
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7WVK
| Crystal structure of human WDR5 in complex with compound 19 | 分子名称: | 1,2-ETHANEDIOL, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... | 著者 | Han, Q.L, Zhang, X.L, Wang, L, Ren, P.X, Cao, Y, Li, K, Bai, F. | 登録日 | 2022-02-10 | 公開日 | 2022-10-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.42 Å) | 主引用文献 | Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44, 2023
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6L94
| The structure of the dioxygenase ABH1 from mouse | 分子名称: | FE (II) ION, Nucleic acid dioxygenase ALKBH1 | 著者 | Xie, W, Wang, C, Li, H, Zhang, Y. | 登録日 | 2019-11-08 | 公開日 | 2020-11-11 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (3.10012341 Å) | 主引用文献 | ALKBH1 promotes lung cancer by regulating m6A RNA demethylation. Biochem Pharmacol, 189, 2021
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6UGH
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7PJY
| Structure of the 70S-EF-G-GDP ribosome complex with tRNAs in chimeric state 1 (CHI1-EF-G-GDP) | 分子名称: | 16S ribosomal RNA, 23S ribosomal RNA, 30S ribosomal protein S10, ... | 著者 | Petrychenko, V, Peng, B.Z, Schwarzer, A.C, Peske, F, Rodnina, M.V, Fischer, N. | 登録日 | 2021-08-24 | 公開日 | 2021-10-20 | 最終更新日 | 2024-04-24 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Structural mechanism of GTPase-powered ribosome-tRNA movement. Nat Commun, 12, 2021
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