7WVK

Crystal structure of human WDR5 in complex with compound 19

Summary for 7WVK

Entry DOI	10.2210/pdb7wvk/pdb
Descriptor	WD repeat-containing protein 5, 1-[2,5-bis(chloranyl)phenyl]sulfonylbenzimidazole, GLYCEROL, ... (5 entities in total)
Functional Keywords	blocker, complex structure, dna binding protein
Biological source	Homo sapiens (human)
Total number of polymer chains	1
Total formula weight	35334.83
Authors	Han, Q.L.,Zhang, X.L.,Wang, L.,Ren, P.X.,Cao, Y.,Li, K.,Bai, F. (deposition date: 2022-02-10, release date: 2022-10-19, Last modification date: 2023-11-29)
Primary citation	Han, Q.L.,Zhang, X.L.,Ren, P.X.,Mei, L.H.,Lin, W.H.,Wang, L.,Cao, Y.,Li, K.,Bai, F. Discovery, evaluation and mechanism study of WDR5-targeted small molecular inhibitors for neuroblastoma. Acta Pharmacol.Sin., 44:877-887, 2023 Cited by PubMed: 36207403 DOI: 10.1038/s41401-022-00999-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.42 Å)

Structure validation