PDB: 242842 件ウェブページステータス検索Chemie searchBIRD

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6OZS	Crystal structure of Mus musculus (Mm) Endonuclease V in complex with a 23mer RNA oligo containing an inosine after a 90 min soak in 10 mM Mg2+ 分子名称: 1,2-ETHANEDIOL, DNA/RNA (5'-R(*CP*GP*GP*UP*AP*AP*CP*CP*C)-D(P*I)-R(P*A)-3'), Endonuclease V, ... 著者 Samara, N.L, Yang, W. 登録日 2019-05-15 公開日 2019-09-04 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2.41 Å) 主引用文献 Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase. Mol.Cell, 76, 2019
7Q8V	Crystal structure of TTBK1 in complex with VNG2.73 (compound 42) 分子名称: PHOSPHATE ION, Tau-tubulin kinase 1, ~{N}-[4-(2-chloranylphenoxy)phenyl]-7~{H}-pyrrolo[2,3-d]pyrimidin-4-amine 著者 Chaikuad, A, Nozal, V, Martinez, A, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2021-11-11 公開日 2022-03-09 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.13 Å) 主引用文献 TDP-43 Modulation by Tau-Tubulin Kinase 1 Inhibitors: A New Avenue for Future Amyotrophic Lateral Sclerosis Therapy. J.Med.Chem., 65, 2022
4WW8	Crystal structure of human carbonic anhydrase isozyme XII with 4-Propylthiobenzenesulfonamide 分子名称: 1,2-ETHANEDIOL, 4-(propylsulfanyl)benzenesulfonamide, Carbonic anhydrase 12, ... 著者 Smirnov, A, Manakova, E, Grazulis, S. 登録日 2014-11-10 公開日 2015-07-01 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Intrinsic thermodynamics of 4-substituted-2,3,5,6-tetrafluorobenzenesulfonamide binding to carbonic anhydrases by isothermal titration calorimetry. Biophys.Chem., 205, 2015
4X22	Crystal structure of Leptospira Interrogans Triosephosphate Isomerase (LiTIM) 分子名称: 1,2-ETHANEDIOL, 2-(2-METHOXYETHOXY)ETHANOL, Triosephosphate isomerase 著者 Pareek, V, Balaram, P, Murthy, M.R.N. 登録日 2014-11-25 公開日 2016-02-10 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.084 Å) 主引用文献 Connecting Active-Site Loop Conformations and Catalysis in Triosephosphate Isomerase: Insights from a Rare Variation at Residue 96 in the Plasmodial Enzyme Chembiochem, 17, 2016
6PGT	Protein Tyrosine Phosphatase 1B (1-301), T177A mutant, vanadate bound state 分子名称: GLYCEROL, Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION 著者 Cui, D.S, Lipchock, J.M, Loria, J.P. 登録日 2019-06-24 公開日 2019-08-07 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 Uncovering the Molecular Interactions in the Catalytic Loop That Modulate the Conformational Dynamics in Protein Tyrosine Phosphatase 1B. J.Am.Chem.Soc., 141, 2019
6P85	E.coli LpxD in complex with compound 3 分子名称: 1-(2-ethoxyphenyl)-4-[(4-methylphenyl)sulfonyl]-1H-1,2,3-triazol-5-amine, 3-hydroxy-7,7-dimethyl-2-phenyl-4-(thiophen-2-yl)-2,6,7,8-tetrahydro-5H-pyrazolo[3,4-b]quinolin-5-one, MAGNESIUM ION, ... 著者 Ma, X, Shia, S. 登録日 2019-06-06 公開日 2019-08-28 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Structural and Biological Basis of Small Molecule Inhibition ofEscherichia coliLpxD Acyltransferase Essential for Lipopolysaccharide Biosynthesis. Acs Infect Dis., 6, 2020
4WZ8	Crystal structure of human-yeast chimera acetyl coA carboxylase CT domain bound to Compound 6 分子名称: 1'-(2H-indazol-5-ylcarbonyl)-1-(propan-2-yl)-1,4-dihydrospiro[indazole-5,4'-piperidin]-7(6H)-one, Acetyl-CoA carboxylase 著者 Vajdos, F.F. 登録日 2014-11-18 公開日 2014-12-10 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.23 Å) 主引用文献 Decreasing the Rate of Metabolic Ketone Reduction in the Discovery of a Clinical Acetyl-CoA Carboxylase Inhibitor for the Treatment of Diabetes. J.Med.Chem., 57, 2014
7PWB	dTDP-sugar epimerase from Coxiella burnetii in complex with dTDP 分子名称: 1,2-ETHANEDIOL, CITRIC ACID, THYMIDINE-5'-DIPHOSPHATE, ... 著者 Cross, A.R, Harmer, N.J, Isupov, M.N. 登録日 2021-10-06 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.87 Å) 主引用文献 Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases. J.Biol.Chem., 298, 2022
7PWH	Structure of the dTDP-sugar epimerase StrM 分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, THYMIDINE-5'-DIPHOSPHATE, ... 著者 Cross, A.R, Harmer, N.J, Isupov, M.N. 登録日 2021-10-06 公開日 2022-04-20 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Spinning sugars in antigen biosynthesis: characterization of the Coxiella burnetii and Streptomyces griseus TDP-sugar epimerases. J.Biol.Chem., 298, 2022
6ZJF	Crystal structure of STK17B (DRAK2) in complex with AP-229 分子名称: 1,2-ETHANEDIOL, 2-[6-(4-cyclopropylphenyl)thieno[3,2-d]pyrimidin-4-yl]sulfanylethanoic acid, Serine/threonine-protein kinase 17B 著者 Chaikuad, A, Picado, A, Willson, T, Knapp, S, Structural Genomics Consortium (SGC) 登録日 2020-06-28 公開日 2020-07-29 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 A Chemical Probe for Dark Kinase STK17B Derives Its Potency and High Selectivity through a Unique P-Loop Conformation. J.Med.Chem., 63, 2020
7PZ3	Structure of an LPMO at 5.37x10^3 Gy 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACRYLIC ACID, ... 著者 Tandrup, T, Muderspach, S.J, Ipsen, J.O, Johansen, K.S, Lo Leggio, L. 登録日 2021-10-11 公開日 2022-08-24 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Changes in active-site geometry on X-ray photoreduction of a lytic polysaccharide monooxygenase active-site copper and saccharide binding. Iucrj, 9, 2022
4XF6	myo-inositol 3-kinase bound with its products (ADP and 1D-myo-inositol 3-phosphate) 分子名称: 1,2,3,4,5,6-HEXAHYDROXY-CYCLOHEXANE, 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, ... 著者 Nagata, R, Fujihashi, M, Miki, K. 登録日 2014-12-26 公開日 2015-06-03 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Crystal Structure and Product Analysis of an Archaeal myo-Inositol Kinase Reveal Substrate Recognition Mode and 3-OH Phosphorylation Biochemistry, 54, 2015
4XEG	Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch 分子名称: 1,2-ETHANEDIOL, ACETIC ACID, DNA (28-MER), ... 著者 Pozharski, E, Malik, S.S, Drohat, A.C. 登録日 2014-12-23 公開日 2015-09-09 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA. Nucleic Acids Res., 43, 2015
8XTP	Comamonas testosteroni KF-1 circularly permuted group II intron Post-2S state 分子名称: MAGNESIUM ION, POTASSIUM ION, RNA (133-MER), ... 著者 Wang, L, Xie, J.H, Zhang, C, Zou, J, Huang, Z.R, Shang, S.T, Chen, X.Y, Yang, Y, Liu, J, Dong, H.H, Huang, D.M, Su, Z.M. 登録日 2024-01-11 公開日 2025-02-12 最終更新日 2025-07-23 実験手法 ELECTRON MICROSCOPY (2.9 Å) 主引用文献 Structural basis of circularly permuted group II intron self-splicing. Nat.Struct.Mol.Biol., 32, 2025
4TMN	SLOW-AND FAST-BINDING INHIBITORS OF THERMOLYSIN DISPLAY DIFFERENT MODES OF BINDING. CRYSTALLOGRAPHIC ANALYSIS OF EXTENDED PHOSPHONAMIDATE TRANSITION-STATE ANALOGUES 分子名称: CALCIUM ION, N-[(S)-[(1R)-1-{[(benzyloxy)carbonyl]amino}-2-phenylethyl](hydroxy)phosphoryl]-L-leucyl-L-alanine, THERMOLYSIN, ... 著者 Holden, H.M, Tronrud, D.E, Monzingo, A.F, Weaver, L.H, Matthews, B.W. 登録日 1987-06-29 公開日 1989-01-09 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Slow- and fast-binding inhibitors of thermolysin display different modes of binding: crystallographic analysis of extended phosphonamidate transition-state analogues. Biochemistry, 26, 1987
6O64	Crystal Structure of Arabidopsis thaliana Spermidine Synthase isoform 2 (AtSPDS2) 分子名称: 1,2-ETHANEDIOL, ACETATE ION, DI(HYDROXYETHYL)ETHER, ... 著者 Sekula, B, Dauter, Z. 登録日 2019-03-05 公開日 2019-06-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Spermidine Synthase (SPDS) Undergoes Concerted Structural Rearrangements Upon Ligand Binding - A Case Study of the Two SPDS Isoforms FromArabidopsis thaliana. Front Plant Sci, 10, 2019
6WCI	Crystal structure of a cysteine desulfurase SufS from Stenotrophomonas maltophilia K279a 分子名称: 1,2-ETHANEDIOL, Cysteine desulfurase, SULFATE ION 著者 Seattle Structural Genomics Center for Infectious Disease (SSGCID) 登録日 2020-03-30 公開日 2020-04-08 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.05 Å) 主引用文献 Crystal structure of a cysteine desulfurase SufS from Stenotrophomonas maltophilia K279a To Be Published
8GLB	Selenomethionine Derivatized Citrate Synthase (CitA) in Mycobacterium tuberculosis with Pyruvate 分子名称: 1,2-ETHANEDIOL, PYRUVIC ACID, citrate synthase 著者 Pathirage, R, Ronning, D, Favrot, L. 登録日 2023-03-21 公開日 2023-06-07 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Mycobacterium tuberculosis CitA activity is modulated by cysteine oxidation and pyruvate binding. Rsc Med Chem, 14, 2023
6OZG	Crystal structure of Thermotoga maritima (Tm) Endonuclease V (E89Q) in complex with a 12mer DNA containing an inosine followed by a ribo-adenosine 分子名称: 1,2-ETHANEDIOL, DNA/RNA (5'-D(*AP*AP*TP*GP*A)-R(P*A)-D(P*GP*AP*T)-R(P*NP*N)-D(P*T)-3'), Endonuclease V, ... 著者 Samara, N.L, Yang, W. 登録日 2019-05-15 公開日 2019-09-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.93 Å) 主引用文献 Evolution of Inosine-Specific Endonuclease V from Bacterial DNase to Eukaryotic RNase. Mol.Cell, 76, 2019
6WIM	CdiB from Escherichia coli 分子名称: 1,2-ETHANEDIOL, DI(HYDROXYETHYL)ETHER, Outer membrane transporter CdiB 著者 Guerin, J, Botos, I, Buchanan, S.K. 登録日 2020-04-10 公開日 2020-11-04 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.6 Å) 主引用文献 Structural insight into toxin secretion by contact dependent growth inhibition transporters. Elife, 9, 2020
4XDT	Crystal structure of Treponema pallidum TP0796 Flavin trafficking protein, a bifunctional FMN transferase/FAD pyrophosphatase, N55Y mutant, FAD bound form 分子名称: 1,2-ETHANEDIOL, ACETATE ION, FAD:protein FMN transferase, ... 著者 Tomchick, D.R, Brautigam, C.A, Deka, R.K, Norgard, M.V. 登録日 2014-12-19 公開日 2015-10-14 最終更新日 2023-09-27 実験手法 X-RAY DIFFRACTION (1.452 Å) 主引用文献 Evidence for Posttranslational Protein Flavinylation in the Syphilis Spirochete Treponema pallidum: Structural and Biochemical Insights from the Catalytic Core of a Periplasmic Flavin-Trafficking Protein. Mbio, 6, 2015
4XDJ	Crystal structure of human two pore domain potassium ion channel TREK2 (K2P10.1) in an alternate conformation (FORM 2) 分子名称: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, POTASSIUM CHANNEL SUBFAMILY K MEMBER 10, POTASSIUM ION, ... 著者 Pike, A.C.W, Dong, Y.Y, Mackenzie, A, Mukhopadhyay, S, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Burgess-Brown, N.A, Carpenter, E.P, Structural Genomics Consortium (SGC) 登録日 2014-12-19 公開日 2015-03-18 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (3.8 Å) 主引用文献 K2P channel gating mechanisms revealed by structures of TREK-2 and a complex with Prozac. Science, 347, 2015
6ONG	Dehaloperoxidate B in complex with substrate 4-F-cresol 分子名称: 1,2-ETHANEDIOL, 4-fluoro-2-methylphenol, Dehaloperoxidase B, ... 著者 Ghiladi, R.A, de Serrano, V.S, Malewschik, T, McGuire, A. 登録日 2019-04-22 公開日 2019-09-11 最終更新日 2024-12-25 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 The multifunctional globin dehaloperoxidase strikes again: Simultaneous peroxidase and peroxygenase mechanisms in the oxidation of EPA pollutants. Arch.Biochem.Biophys., 673, 2019
6ONX	Dehaloperoxidase B in complex with substrate 4-Br-cresol 分子名称: 1,2-ETHANEDIOL, 4-bromo-2-methylphenol, DI(HYDROXYETHYL)ETHER, ... 著者 Ghiladi, R.A, de Serrano, V.S, Malewschik, T. 登録日 2019-04-22 公開日 2019-09-25 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 The multifunctional globin dehaloperoxidase strikes again: Simultaneous peroxidase and peroxygenase mechanisms in the oxidation of EPA pollutants. Arch.Biochem.Biophys., 673, 2019
4XGP	Crystal Structure of E112A/H234A Mutant of Stationary Phase Survival Protein (SurE) from Salmonella typhimurium co-crystallized and soaked with AMP. 分子名称: 1,2-ETHANEDIOL, 5'/3'-nucleotidase SurE, ADENINE, ... 著者 Mathiharan, Y.K, Murthy, M.R.N. 登録日 2015-01-01 公開日 2015-09-09 最終更新日 2023-11-08 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Insights into stabilizing interactions in the distorted domain-swapped dimer of Salmonella typhimurium survival protein. Acta Crystallogr.,Sect.D, 71, 2015

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