4XEG

Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch

Summary for 4XEG

DescriptorG/T mismatch-specific thymine DNA glycosylase, DNA (28-MER), 1,2-ETHANEDIOL, ... (6 entities in total)
Functional Keywordsdna glycosylase, abasic site, enzyme-product complex, 5-hydroxymethyluracil, hydrolase-dna complex, hydrolase/dna
Biological sourceHomo sapiens (Human)
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Cellular locationNucleus  Q13569
Total number of polymer chains3
Total molecular weight40494.96
Authors
Pozharski, E.,Malik, S.S.,Drohat, A.C. (deposition date: 2014-12-23, release date: 2015-09-09, Last modification date: 2017-09-06)
Primary citation
Malik, S.S.,Coey, C.T.,Varney, K.M.,Pozharski, E.,Drohat, A.C.
Thymine DNA glycosylase exhibits negligible affinity for nucleobases that it removes from DNA.
Nucleic Acids Res., 43:9541-9552, 2015
PubMed: 26358812 (PDB entries with the same primary citation)
DOI: 10.1093/nar/gkv890
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.72 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24061.0%2.4%2.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution