4XEG

Structure of the enzyme-product complex resulting from TDG action on a G/hmU mismatch

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0000700	molecular_function	mismatch base pair DNA N-glycosylase activity
A	0006285	biological_process	base-excision repair, AP site formation

Functional Information from PDB Data

site_id	AC1
Number of Residues	5
Details	binding site for residue EDO A 401

Chain	Residue
A	ASN131
A	LEU132
A	GLN223
A	ARG225
A	HOH512

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site_id	AC2
Number of Residues	1
Details	binding site for residue EDO A 402

Chain	Residue
A	HIS287

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site_id	AC3
Number of Residues	9
Details	binding site for residue ACY A 403

Chain	Residue
A	TYR152
A	ASN191
A	HOH570
A	HOH572
A	HOH575
D	ORP17
A	GLY138
A	ILE139
A	ASN140

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site_id	AC4
Number of Residues	3
Details	binding site for residue ACY A 404

Chain	Residue
A	GLU170
A	LYS184
A	TYR185

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site_id	AC5
Number of Residues	4
Details	binding site for residue ACY A 405

Chain	Residue
A	ASN249
A	PRO256
A	HOH535
A	HOH563

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site_id	AC6
Number of Residues	28
Details	binding site for Poly-Saccharide residues DA D 16 through DG D 18

Chain	Residue
A	ASN140
A	ASN157
A	GLY199
A	SER200
A	LYS201
A	SER271
A	SER273
A	ALA274
A	ARG275
A	CYS276
A	ALA277
A	GLN278
A	ACY403
A	HOH568
C	DA10
C	DC11
C	DG12
C	DT13
C	DG14
D	DC15
D	DT19
D	HOH124
D	HOH127
D	HOH129
D	HOH157
D	HOH163
D	HOH164
D	HOH173

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Cross-link: {"description":"Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)","evidences":[{"source":"PubMed","id":"28112733","evidenceCode":"ECO:0007744"}]}

Chain

Residue

Details

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Catalytic Information from CSA

site_id	MCSA1
Number of Residues	2
Details	M-CSA 834

Chain	Residue	Details
A	ASN140	electrostatic interaction
A	HIS151	proton acceptor, proton donor

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