5DFA
| 3D structure of the E323A catalytic mutant of Gan42B, a GH42 beta-galactosidase from G. stearothermophilus | 分子名称: | Beta-galactosidase, GLYCEROL, ZINC ION | 著者 | Solomon, H.V, Tabachnikov, O, Lansky, S, Feinberg, H, Govada, L, Chayen, N.E, Shoham, Y, Shoham, G. | 登録日 | 2015-08-26 | 公開日 | 2015-12-09 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structure-function relationships in Gan42B, an intracellular GH42 beta-galactosidase from Geobacillus stearothermophilus. Acta Crystallogr.,Sect.D, 71, 2015
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7M23
| Human carbonic anhydrase II in complex with troglitazone | 分子名称: | (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, Carbonic anhydrase 2, ZINC ION | 著者 | Mueller, S.L, Peat, T.S. | 登録日 | 2021-03-16 | 公開日 | 2022-02-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening. Molecules, 26, 2021
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7M26
| Human carbonic anhydrase II in complex with pioglitazone | 分子名称: | (5R)-5-{4-[2-(5-ethylpyridin-2-yl)ethoxy]benzyl}-1,3-thiazolidine-2,4-dione, Carbonic anhydrase 2, ZINC ION | 著者 | Mueller, S.L, Peat, T.S. | 登録日 | 2021-03-16 | 公開日 | 2022-02-02 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | 主引用文献 | The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening. Molecules, 26, 2021
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7M24
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3L51
| Crystal Structure of the Mouse Condensin Hinge Domain | 分子名称: | GLYCEROL, Structural maintenance of chromosomes protein 2, Structural maintenance of chromosomes protein 4 | 著者 | Griese, J.J, Hopfner, K.-P. | 登録日 | 2009-12-21 | 公開日 | 2010-02-16 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.506 Å) | 主引用文献 | Structure and DNA binding activity of the mouse condensin hinge domain highlight common and diverse features of SMC proteins Nucleic Acids Res., 38, 2010
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6ZRY
| 6-dimethylallyl tryptophan synthase | 分子名称: | CALCIUM ION, DI(HYDROXYETHYL)ETHER, DMATS type aromatic prenyltransferase, ... | 著者 | Ostertag, E, Stehle, T, Zocher, G. | 登録日 | 2020-07-15 | 公開日 | 2020-12-09 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.652 Å) | 主引用文献 | Reprogramming Substrate and Catalytic Promiscuity of Tryptophan Prenyltransferases. J.Mol.Biol., 433, 2020
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5DCY
| Iridoid synthase G150A mutant from Catharanthus roseus - binary complex with NADP+ | 分子名称: | 1,2-ETHANEDIOL, Iridoid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Caputi, L, Kries, H, Stevenson, C.E.M, Kamileen, M.O, Sherden, N.H, Geu-Flores, F, Lawson, D.M, O'Connor, S.E. | 登録日 | 2015-08-24 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.45 Å) | 主引用文献 | Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat.Chem.Biol., 12, 2016
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5DDH
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6RZG
| Galectin-3C in complex with meta-fluoroaryltriazole galactopyranosyl 1-thio-D-glucopyranoside derivative | 分子名称: | (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(3-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol, CHLORIDE ION, Galectin-3 | 著者 | Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. | 登録日 | 2019-06-13 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.015 Å) | 主引用文献 | Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. Jacs Au, 1, 2021
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4HB4
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3GAN
| Crystal structure of gene product from Arabidopsis thaliana At3g22680 with bound suramin | 分子名称: | 8,8'-[CARBONYLBIS[IMINO-3,1-PHENYLENECARBONYLIMINO(4-METHYL-3,1-PHENYLENE)CARBONYLIMINO]]BIS-1,3,5-NAPHTHALENETRISULFON IC ACID, CHLORIDE ION, Uncharacterized protein At3g22680 | 著者 | Burgie, E.S, Bingman, C.A, Wesenberg, G.E, Phillips Jr, G.N, Center for Eukaryotic Structural Genomics (CESG) | 登録日 | 2009-02-17 | 公開日 | 2009-03-03 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Crystal structure of gene product from Arabidopsis thaliana At3g22680 with bound suramin To be Published
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1XJR
| The Structure of a Rigorously Conserved RNA Element Within the SARS Virus Genome | 分子名称: | MAGNESIUM ION, s2m RNA | 著者 | Robertson, M.P, Igel, H, Baertsch, R, Haussler, D, Ares Jr, M, Scott, W.G. | 登録日 | 2004-09-24 | 公開日 | 2005-02-01 | 最終更新日 | 2024-02-14 | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | 主引用文献 | The structure of a rigorously conserved RNA element within the SARS virus genome Plos Biol., 3, 2005
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4RMT
| Crystal structure of the D98N Beta-2 Microglobulin mutant | 分子名称: | ACETATE ION, Beta-2-microglobulin, DI(HYDROXYETHYL)ETHER, ... | 著者 | de Rosa, M, Bolognesi, M, Ricagno, S. | 登録日 | 2014-10-22 | 公開日 | 2015-11-18 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.242 Å) | 主引用文献 | Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. Plos One, 10, 2015
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4TGL
| CATALYSIS AT THE INTERFACE: THE ANATOMY OF A CONFORMATIONAL CHANGE IN A TRIGLYCERIDE LIPASE | 分子名称: | DIETHYL PHOSPHONATE, TRIACYL-GLYCEROL ACYLHYDROLASE | 著者 | Derewenda, U, Brzozowski, A.M, Lawson, D, Derewenda, Z.S. | 登録日 | 1991-07-29 | 公開日 | 1993-07-15 | 最終更新日 | 2024-06-05 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Catalysis at the interface: the anatomy of a conformational change in a triglyceride lipase. Biochemistry, 31, 1992
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1CN0
| CRYSTAL STRUCTURE OF D(ACCCT) | 分子名称: | DNA (5'-D(*AP*CP*CP*CP*T)-3') | 著者 | Weil, J, Min, T, Cheng, Y, Wang, S, Sutherland, C, Sinha, N, Kang, C. | 登録日 | 1999-05-24 | 公開日 | 2000-05-24 | 最終更新日 | 2023-08-02 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Stabilization of the i-motif by intramolecular adenine-adenine-thymine base triple in the structure of d(ACCCT). Acta Crystallogr.,Sect.D, 55, 1999
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6RZF
| Galectin-3C in complex with ortho-fluoroaryltriazole galactopyranosyl 1-thio-D-glucopyranoside derivative | 分子名称: | (2~{S},3~{R},4~{S},5~{S},6~{R})-2-[(2~{S},3~{R},4~{S},5~{R},6~{R})-4-[4-(2-fluorophenyl)-1,2,3-triazol-1-yl]-6-(hydroxymethyl)-3,5-bis(oxidanyl)oxan-2-yl]sulfanyl-6-(hydroxymethyl)oxane-3,4,5-triol, Galectin-3 | 著者 | Kumar, R, Peterson, K, Nilsson, U.J, Logan, D.T. | 登録日 | 2019-06-13 | 公開日 | 2020-07-08 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.016 Å) | 主引用文献 | Entropy-Entropy Compensation between the Protein, Ligand, and Solvent Degrees of Freedom Fine-Tunes Affinity in Ligand Binding to Galectin-3C. Jacs Au, 1, 2021
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1CRB
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7M49
| DNA Polymerase Lambda, TTP:At Mn2+ Reaction State Ternary Complex, 5 min | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2021-03-21 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nat Commun, 13, 2022
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7M4B
| DNA Polymerase Lambda, TTP:At Mn2+ Product State Ternary Complex, 60 min | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2021-03-21 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.66 Å) | 主引用文献 | Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nat Commun, 13, 2022
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5DCU
| Iridoid synthase from Catharanthus roseus - ternary complex with NADP+ and triethylene glycol carboxylic acid | 分子名称: | 1,2-ETHANEDIOL, Iridoid synthase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Caputi, L, Kries, H, Stevenson, C.E.M, Kamileen, M.O, Sherden, N.H, Geu-Flores, F, Lawson, D.M, O'Connor, S.E. | 登録日 | 2015-08-24 | 公開日 | 2015-10-28 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | 主引用文献 | Structural determinants of reductive terpene cyclization in iridoid biosynthesis. Nat.Chem.Biol., 12, 2016
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7M47
| DNA Polymerase Lambda, TTP:At Mg2+ Product State Ternary Complex, 60 min | 分子名称: | 1,2-ETHANEDIOL, DNA (5'-D(*CP*AP*GP*TP*AP*CP*T)-3'), DNA (5'-D(*CP*GP*GP*CP*AP*GP*TP*AP*CP*TP*G)-3'), ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2021-03-21 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.648 Å) | 主引用文献 | Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nat Commun, 13, 2022
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7M4H
| DNA Polymerase Lambda, dCTP:At Mn2+ Reaction State Ternary Complex, 225 min | 分子名称: | 1,2-ETHANEDIOL, 2'-DEOXYCYTIDINE-5'-TRIPHOSPHATE, DNA (5'-D(*CP*AP*GP*TP*AP*CP*C)-3'), ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2021-03-21 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.923 Å) | 主引用文献 | Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nat Commun, 13, 2022
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5DE1
| Crystal structure of human IDH1 in complex with GSK321A | 分子名称: | (7R)-1-(4-fluorobenzyl)-N-{3-[(1S)-1-hydroxyethyl]phenyl}-7-methyl-5-(1H-pyrrol-2-ylcarbonyl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c]pyridine-3-carboxamide, Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Concha, N.O, Smallwood, A, Qi, H. | 登録日 | 2015-08-25 | 公開日 | 2015-10-07 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat.Chem.Biol., 11, 2015
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4HAZ
| Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1 | 分子名称: | CHLORIDE ION, Exportin-1, GTP-binding nuclear protein Ran, ... | 著者 | Sun, Q, Chook, Y.M. | 登録日 | 2012-09-27 | 公開日 | 2013-01-09 | 最終更新日 | 2017-07-26 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1. Proc.Natl.Acad.Sci.USA, 110, 2013
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7M43
| DNA Polymerase Lambda, TTP:At Ca2+ Ground State Ternary Complex | 分子名称: | 1,2-ETHANEDIOL, CALCIUM ION, DNA (5'-D(*CP*AP*GP*TP*AP*C)-3'), ... | 著者 | Jamsen, J.A, Wilson, S.H. | 登録日 | 2021-03-21 | 公開日 | 2022-07-06 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.978 Å) | 主引用文献 | Watching right and wrong nucleotide insertion captures hidden polymerase fidelity checkpoints. Nat Commun, 13, 2022
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