7M24

Human carbonic anhydrase II in complex with (R)-rosiglitazone

Summary for 7M24

Entry DOI	10.2210/pdb7m24/pdb
Descriptor	Carbonic anhydrase 2, ZINC ION, (R)-ROSIGLITAZONE, ... (4 entities in total)
Functional Keywords	glitazone drug class, lyase-lyase inhibitor complex, lyase/lyase inhibitor
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	29493.62
Authors	Mueller, S.L.,Peat, T.S. (deposition date: 2021-03-16, release date: 2022-02-02, Last modification date: 2023-10-18)
Primary citation	Mueller, S.L.,Chrysanthopoulos, P.K.,Halili, M.A.,Hepburn, C.,Nebl, T.,Supuran, C.T.,Nocentini, A.,Peat, T.S.,Poulsen, S.A. The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening. Molecules, 26:-, 2021 Cited by PubMed: 34070212 DOI: 10.3390/molecules26103010 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.3 Å)

Structure validation