4RMT

Crystal structure of the D98N Beta-2 Microglobulin mutant

Summary for 4RMT

Entry DOI	10.2210/pdb4rmt/pdb
Related	2YXF 4FXL 4RMQ 4RMR 4RMS 4RMU 4RMV 4RMW
Descriptor	Beta-2-microglobulin, TRIETHYLENE GLYCOL, DI(HYDROXYETHYL)ETHER, ... (5 entities in total)
Functional Keywords	immunoglobin, beta-sandwitch, amyloidosis, pathologic mutation, genetic disease, mhc class i, immune system
Biological source	Homo sapiens (human)
Cellular location	Secreted : P61769
Total number of polymer chains	1
Total formula weight	12193.71
Authors	de Rosa, M.,Bolognesi, M.,Ricagno, S. (deposition date: 2014-10-22, release date: 2015-11-18, Last modification date: 2023-09-20)
Primary citation	de Rosa, M.,Barbiroli, A.,Giorgetti, S.,Mangione, P.P.,Bolognesi, M.,Ricagno, S. Decoding the Structural Bases of D76N 2-Microglobulin High Amyloidogenicity through Crystallography and Asn-Scan Mutagenesis. Plos One, 10:e0144061-e0144061, 2015 Cited by PubMed: 26625273 DOI: 10.1371/journal.pone.0144061 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.242 Å)

Structure validation