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4HAZ

Crystal structure of CRM1 inhibitor Leptomycin B in complex with CRM1(R543S,K548E,K579Q)-Ran-RanBP1

Summary for 4HAZ
Entry DOI10.2210/pdb4haz/pdb
Related4GMX 4GPT 4HAT 4HAU 4HAV 4HAW 4HAX 4HAY 4HB0 4HB2 4HB3 4HB4
DescriptorGTP-binding nuclear protein Ran, Ran-specific GTPase-activating protein 1, Exportin-1, ... (8 entities in total)
Functional Keywordsheat repeat, nuclear export, ran-ranbp1, lmb, leptomycin b, protein transport-antibiotic complex, protein transport/antibiotic
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus : P62826 P30822
Cytoplasm: P41920
Total number of polymer chains3
Total formula weight159427.01
Authors
Sun, Q.,Chook, Y.M. (deposition date: 2012-09-27, release date: 2013-01-09, Last modification date: 2017-07-26)
Primary citationSun, Q.,Carrasco, Y.P.,Hu, Y.,Guo, X.,Mirzaei, H.,Macmillan, J.,Chook, Y.M.
Nuclear export inhibition through covalent conjugation and hydrolysis of Leptomycin B by CRM1.
Proc.Natl.Acad.Sci.USA, 110:1303-1308, 2013
Cited by
PubMed: 23297231
DOI: 10.1073/pnas.1217203110
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.9 Å)
Structure validation

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