7M23

Human carbonic anhydrase II in complex with troglitazone

Summary for 7M23

• Entry DOI: 10.2210/pdb7m23/pdb
• Descriptor: Carbonic anhydrase 2, ZINC ION, (5R)-5-(4-{[(2R)-6-HYDROXY-2,5,7,8-TETRAMETHYL-3,4-DIHYDRO-2H-CHROMEN-2-YL]METHOXY}BENZYL)-1,3-THIAZOLIDINE-2,4-DIONE, ... (4 entities in total)
• Functional Keywords: glitazone drug class, lyase-lyase inhibitor complex, lyase/lyase inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 1
• Total formula weight: 29577.73

Authors

Mueller, S.L.,Peat, T.S. (deposition date: 2021-03-16, release date: 2022-02-02, Last modification date: 2023-10-18)

• Primary citation: Mueller, S.L.,Chrysanthopoulos, P.K.,Halili, M.A.,Hepburn, C.,Nebl, T.,Supuran, C.T.,Nocentini, A.,Peat, T.S.,Poulsen, S.A.; The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors-A Spin-Off Discovery from Fragment Screening.; Molecules, 26:-, 2021; PubMed: 34070212; DOI: 10.3390/molecules26103010

Experimental method

X-RAY DIFFRACTION (1.3 Å)