PDB: 224004 件ウェブページステータス検索Chemie searchBIRD

---

6ZX3	OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution 分子名称: GLYCEROL, PROLINE, SULFATE ION, ... 著者 Tittmann, K, Rindfleisch, S, Schimdt, T. 登録日 2020-07-29 公開日 2022-02-23 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
4LNZ	Crystal structure of human Myosin 5b globular domain 分子名称: Unconventional myosin-Vb 著者 Velvarska, H, Niessing, D. 登録日 2013-07-12 公開日 2013-12-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (3.11 Å) 主引用文献 Structural insights into the globular tails of the human type v myosins myo5a, myo5b, and myo5c. Plos One, 8, 2013
7A4Q	The Crystal structure of RO4613269 bound to CK2alpha 分子名称: 2-methoxyimino-5-(quinolin-6-ylmethyl)-1,3-thiazol-4-one, Casein kinase II subunit alpha 著者 Brear, P, Hyvonen, M. 登録日 2020-08-20 公開日 2022-06-08 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.42 Å) 主引用文献 Chemical proteomics reveals the target landscape of 1,000 kinase inhibitors. Nat.Chem.Biol., 2023
7NPQ	Crystal structure of the human LL37(17-29) I24C mutant antimicrobial peptide 分子名称: Cathelicidin antimicrobial peptide 著者 Landau, M, Engelberg, Y. 登録日 2021-02-28 公開日 2022-02-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Rare by Natural Selection: Disulfide-Bonded Supramolecular Antimicrobial Peptides. Biomacromolecules, 23, 2022
4MDR	Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP) 分子名称: AP-4 complex subunit mu-1, Amyloid beta A4 protein 著者 Ross, B.H, Lin, Y, Corales, E.A, Burgos, P.V, Mardones, G.A. 登録日 2013-08-23 公開日 2014-03-12 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4. Plos One, 9, 2014
4MDY	Crystal structure of periplasmic solute binding protein from Mycobacterium smegmatis str. MC2 155 分子名称: DI(HYDROXYETHYL)ETHER, Periplasmic binding protein 著者 Chang, C, Wu, R, Endres, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) 登録日 2013-08-23 公開日 2013-09-04 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (1.78 Å) 主引用文献 Crystal structure of periplasmic solute binding protein from Mycobacterium smegmatis str. MC2 155 To be Published
4LOS	C1s CUB2-CCP1 分子名称: CALCIUM ION, Complement C1s subcomponent heavy chain 著者 Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E, Gingras, A.R. 登録日 2013-07-13 公開日 2013-08-07 最終更新日 2013-09-04 実験手法 X-RAY DIFFRACTION (1.996 Å) 主引用文献 Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4LOT	C1s CUB2-CCP1-CCP2 分子名称: Complement C1s subcomponent heavy chain 著者 Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. 登録日 2013-07-13 公開日 2013-08-07 最終更新日 2013-09-04 実験手法 X-RAY DIFFRACTION (2.92 Å) 主引用文献 Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
4M07	Crystal Structure of Mutant Chlorite Dismutase from Candidatus Nitrospira defluvii W145F 分子名称: 1,2-ETHANEDIOL, Chlorite dismutase, GLYCEROL, ... 著者 Hagmueller, A, Gysel, K, Djinovic-Carugo, K. 登録日 2013-08-01 公開日 2014-01-15 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Manipulating conserved heme cavity residues of chlorite dismutase: effect on structure, redox chemistry, and reactivity. Biochemistry, 53, 2014
4D8D	Crystal structure of HIV-1 NEF Fyn-SH3 R96W variant 分子名称: GLYCEROL, Protein Nef, Tyrosine-protein kinase Fyn 著者 Arold, S.T, Hoh, F, Dumas, C. 登録日 2012-01-10 公開日 2013-01-16 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2.5201 Å) 主引用文献 Synergy and allostery in ligand binding by HIV-1 Nef. Biochem.J., 478, 2021
4M95	d(ATCCGTTATAACGGAT)complexed with Moloney Murine Leukemia virus reverse transcriptase catalytic fragment 分子名称: 1,2-ETHANEDIOL, 5' d(ATCCGTTA) 3', 5' d(TAACGGAT) 3', ... 著者 Singh, I. 登録日 2013-08-14 公開日 2014-03-12 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (1.72 Å) 主引用文献 The structure of an authentic spore photoproduct lesion in DNA suggests a basis for recognition. Acta Crystallogr.,Sect.D, 70, 2014
4MF3	Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist 分子名称: (3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 1 著者 Martinez-Perez, J.A, Iyengar, S, Shannon, H.E, Bleakman, D, Alt, A, Clawson, D.K, Arnold, B.M, Bell, M.G, Bleisch, T.J, Castano, A.M, Del Prado, M, Dominguez, E, Escribano, A.M, Filla, S.A, Ho, K.H, Hudziak, K.J, Jones, C.K, Katofiasc, M.A, Mateo, A, Mathes, B.M, Mattiuz, E.L, Ogden, A.M.L, Phebus, L.A, Simmons, R.M.A, Stack, D.R, Stratford, R.E, Winter, M.A, Wu, Z, Ornstein, P.L. 登録日 2013-08-27 公開日 2014-05-07 最終更新日 2017-11-15 実験手法 X-RAY DIFFRACTION (3 Å) 主引用文献 GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorg.Med.Chem.Lett., 23, 2013
7N2G	MicroED structure of human CPEB3 segment(154-161) kinked polymorph phased by ARCIMBOLDO-BORGES 分子名称: CPEB3 著者 Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. 登録日 2021-05-29 公開日 2022-06-01 最終更新日 2024-05-22 実験手法 ELECTRON CRYSTALLOGRAPHY (1.201 Å) 主引用文献 Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
7N2J	MicroED structure of a mutant mammalian prion segment phased by ARCIMBOLDO-BORGES 分子名称: prion protein 著者 Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. 登録日 2021-05-29 公開日 2022-06-01 最終更新日 2024-05-22 実験手法 ELECTRON CRYSTALLOGRAPHY (1.5 Å) 主引用文献 Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
7N2K	MicroED structure of sequence variant of repeat segment of the yeast prion New1p phased by ARCIMBOLDO-BORGES 分子名称: prion New1p 著者 Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. 登録日 2021-05-29 公開日 2022-06-01 最終更新日 2024-05-22 実験手法 ELECTRON CRYSTALLOGRAPHY (1.301 Å) 主引用文献 Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
7N1S	Crystal Structure Analysis of Xac Nucleotide Pyrophosphatase/Phosphodiesterase 分子名称: Phosphodiesterase-nucleotide pyrophosphatase, TETRAETHYLENE GLYCOL, ZINC ION 著者 Fernandez, D, Li, L, Brown, J.A, Carozza, J.A. 登録日 2021-05-28 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
4LR6	Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment 分子名称: 3-methyl-4-phenyl-1,2-oxazol-5-amine, Bromodomain-containing protein 4, FORMIC ACID 著者 Jayaram, H, Poy, F, Gehling, V, Hewitt, M, Vaswani, R, Leblanc, Y, Cote, A, Nasveschuk, C, Taylor, A, Harmange, J.-C, Audia, J, Pardo, E, Joshi, S, Sandy, P, Mertz, J, Sims, R, Bergeron, L, Bryant, B, Ravichandran, S, Yellapuntala, S, Nandana, B.S, Birudukota, S, Albrecht, B, Bellon, S. 登録日 2013-07-19 公開日 2013-08-07 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.29 Å) 主引用文献 Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. ACS Med Chem Lett, 4, 2013
7N2Y	Crystal Structure of a de Novo Three-stranded Coiled Coil Peptide Containing a dual Tris-thiolate Binding Site for Heavy Metal Complexes 分子名称: Apo-(GRAND CoilSerL16CL23C)3, ZINC ION 著者 Ruckthong, L, Stuckey, J.A, Pecoraro, V.L. 登録日 2021-05-30 公開日 2022-06-01 最終更新日 2023-10-18 実験手法 X-RAY DIFFRACTION (2.08 Å) 主引用文献 Open Reading Frame 1 Protein of the Human Long Interspersed Nuclear Element 1 Retrotransposon Binds Multiple Equivalents of Lead. J.Am.Chem.Soc., 143, 2021
7N2E	MicroED structure of human CPEB3 segment (154-161) straight polymorph 分子名称: CPEB3 著者 Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. 登録日 2021-05-29 公開日 2022-06-01 最終更新日 2024-05-22 実験手法 ELECTRON CRYSTALLOGRAPHY (1 Å) 主引用文献 Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
4LTE	Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor 分子名称: 2,6-DIAMINO-HEXANOIC ACID AMIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FUMARIC ACID, ... 著者 Foda, Z.H, Seeliger, M.A, Saghatelian, A, Liu, D.R. 登録日 2013-07-23 公開日 2014-05-21 最終更新日 2024-04-24 実験手法 X-RAY DIFFRACTION (2.705 Å) 主引用文献 Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511, 2014
4MDQ	Structure of a novel submicromolar MDM2 inhibitor 分子名称: 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2 著者 Bista, M, Popowicz, G, Holak, T.A. 登録日 2013-08-23 公開日 2013-11-13 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.119 Å) 主引用文献 Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21, 2013
4MFA	Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming TTP 分子名称: DNA polymerase beta, MAGNESIUM ION, PHOSPHATE ION, ... 著者 Koag, M.C, Min, K, Monzingo, A.F, Lee, S. 登録日 2013-08-27 公開日 2014-08-27 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2.27 Å) 主引用文献 Structures of human DNA polymerase beta inserting bases opposite templating O6MG To be Published
4MI0	Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) 分子名称: Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION 著者 Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) 登録日 2013-08-30 公開日 2013-09-25 最終更新日 2024-02-28 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
4LOA	X-ray structure of the de-novo design amidase at the resolution 1.8A, Northeast Structural Genomics Consortium (NESG) Target OR398 分子名称: CHLORIDE ION, DI(HYDROXYETHYL)ETHER, De-novo design amidase 著者 Kuzin, A, Lew, S, Vorobiev, S.M, Seetharaman, J, Sahdev, S, Xiao, R, Maglaqui, M, Kogan, S, Khersonsky, O, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) 登録日 2013-07-12 公開日 2013-08-07 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (1.819 Å) 主引用文献 Northeast Structural Genomics Consortium Target OR398 To be Published
4LOR	C1s CUB1-EGF-CUB2 in complex with a collagen-like peptide from C1q 分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C1s subcomponent heavy chain, ... 著者 Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. 登録日 2013-07-13 公開日 2013-08-07 最終更新日 2020-07-29 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013

<804805806807808809810811812813814815816817818819>