6ZX3
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![BU of 6zx3 by Molmil](/molmil-images/mine/6zx3) | OMPD-domain of human UMPS in complex with 6-thiocarboxamido-UMP at 1.15 Angstroms resolution | 分子名称: | GLYCEROL, PROLINE, SULFATE ION, ... | 著者 | Tittmann, K, Rindfleisch, S, Schimdt, T. | 登録日 | 2020-07-29 | 公開日 | 2022-02-23 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (1.15 Å) | 主引用文献 | Ground-state destabilization by electrostatic repulsion is not a driving force in orotidine-5-monophosphate decarboxylase catalysis Nat Catal, 5, 2022
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4LNZ
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7A4Q
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![BU of 7a4q by Molmil](/molmil-images/mine/7a4q) | |
7NPQ
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4MDR
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![BU of 4mdr by Molmil](/molmil-images/mine/4mdr) | Crystal structure of adaptor protein complex 4 (AP-4) mu4 subunit C-terminal domain D190A mutant, in complex with a sorting peptide from the amyloid precursor protein (APP) | 分子名称: | AP-4 complex subunit mu-1, Amyloid beta A4 protein | 著者 | Ross, B.H, Lin, Y, Corales, E.A, Burgos, P.V, Mardones, G.A. | 登録日 | 2013-08-23 | 公開日 | 2014-03-12 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structural and Functional Characterization of Cargo-Binding Sites on the mu 4-Subunit of Adaptor Protein Complex 4. Plos One, 9, 2014
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4MDY
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4LOS
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![BU of 4los by Molmil](/molmil-images/mine/4los) | C1s CUB2-CCP1 | 分子名称: | CALCIUM ION, Complement C1s subcomponent heavy chain | 著者 | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E, Gingras, A.R. | 登録日 | 2013-07-13 | 公開日 | 2013-08-07 | 最終更新日 | 2013-09-04 | 実験手法 | X-RAY DIFFRACTION (1.996 Å) | 主引用文献 | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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4LOT
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4M07
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![BU of 4m07 by Molmil](/molmil-images/mine/4m07) | Crystal Structure of Mutant Chlorite Dismutase from Candidatus Nitrospira defluvii W145F | 分子名称: | 1,2-ETHANEDIOL, Chlorite dismutase, GLYCEROL, ... | 著者 | Hagmueller, A, Gysel, K, Djinovic-Carugo, K. | 登録日 | 2013-08-01 | 公開日 | 2014-01-15 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Manipulating conserved heme cavity residues of chlorite dismutase: effect on structure, redox chemistry, and reactivity. Biochemistry, 53, 2014
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4D8D
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4M95
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4MF3
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![BU of 4mf3 by Molmil](/molmil-images/mine/4mf3) | Crystal Structure of Human GRIK1 complexed with a 6-(tetrazolyl)aryl decahydroisoquinoline antagonist | 分子名称: | (3S,4aS,6S,8aR)-6-[3-chloro-2-(1H-tetrazol-5-yl)phenoxy]decahydroisoquinoline-3-carboxylic acid, Glutamate receptor ionotropic, kainate 1 | 著者 | Martinez-Perez, J.A, Iyengar, S, Shannon, H.E, Bleakman, D, Alt, A, Clawson, D.K, Arnold, B.M, Bell, M.G, Bleisch, T.J, Castano, A.M, Del Prado, M, Dominguez, E, Escribano, A.M, Filla, S.A, Ho, K.H, Hudziak, K.J, Jones, C.K, Katofiasc, M.A, Mateo, A, Mathes, B.M, Mattiuz, E.L, Ogden, A.M.L, Phebus, L.A, Simmons, R.M.A, Stack, D.R, Stratford, R.E, Winter, M.A, Wu, Z, Ornstein, P.L. | 登録日 | 2013-08-27 | 公開日 | 2014-05-07 | 最終更新日 | 2017-11-15 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | GluK1 antagonists from 6-(tetrazolyl)phenyl decahydroisoquinoline derivatives: in vitro profile and in vivo analgesic efficacy. Bioorg.Med.Chem.Lett., 23, 2013
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7N2G
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![BU of 7n2g by Molmil](/molmil-images/mine/7n2g) | MicroED structure of human CPEB3 segment(154-161) kinked polymorph phased by ARCIMBOLDO-BORGES | 分子名称: | CPEB3 | 著者 | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | 登録日 | 2021-05-29 | 公開日 | 2022-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.201 Å) | 主引用文献 | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2J
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![BU of 7n2j by Molmil](/molmil-images/mine/7n2j) | MicroED structure of a mutant mammalian prion segment phased by ARCIMBOLDO-BORGES | 分子名称: | prion protein | 著者 | Richards, L.S, Flores, M.D, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | 登録日 | 2021-05-29 | 公開日 | 2022-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.5 Å) | 主引用文献 | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N2K
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![BU of 7n2k by Molmil](/molmil-images/mine/7n2k) | MicroED structure of sequence variant of repeat segment of the yeast prion New1p phased by ARCIMBOLDO-BORGES | 分子名称: | prion New1p | 著者 | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | 登録日 | 2021-05-29 | 公開日 | 2022-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1.301 Å) | 主引用文献 | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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7N1S
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![BU of 7n1s by Molmil](/molmil-images/mine/7n1s) | Crystal Structure Analysis of Xac Nucleotide Pyrophosphatase/Phosphodiesterase | 分子名称: | Phosphodiesterase-nucleotide pyrophosphatase, TETRAETHYLENE GLYCOL, ZINC ION | 著者 | Fernandez, D, Li, L, Brown, J.A, Carozza, J.A. | 登録日 | 2021-05-28 | 公開日 | 2022-06-01 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | ENPP1's regulation of extracellular cGAMP is a ubiquitous mechanism of attenuating STING signaling. Proc.Natl.Acad.Sci.USA, 119, 2022
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4LR6
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![BU of 4lr6 by Molmil](/molmil-images/mine/4lr6) | Structure of BRD4 bromodomain 1 with a 3-methyl-4-phenylisoxazol-5-amine fragment | 分子名称: | 3-methyl-4-phenyl-1,2-oxazol-5-amine, Bromodomain-containing protein 4, FORMIC ACID | 著者 | Jayaram, H, Poy, F, Gehling, V, Hewitt, M, Vaswani, R, Leblanc, Y, Cote, A, Nasveschuk, C, Taylor, A, Harmange, J.-C, Audia, J, Pardo, E, Joshi, S, Sandy, P, Mertz, J, Sims, R, Bergeron, L, Bryant, B, Ravichandran, S, Yellapuntala, S, Nandana, B.S, Birudukota, S, Albrecht, B, Bellon, S. | 登録日 | 2013-07-19 | 公開日 | 2013-08-07 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (1.29 Å) | 主引用文献 | Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors. ACS Med Chem Lett, 4, 2013
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7N2Y
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7N2E
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![BU of 7n2e by Molmil](/molmil-images/mine/7n2e) | MicroED structure of human CPEB3 segment (154-161) straight polymorph | 分子名称: | CPEB3 | 著者 | Flores, M.D, Richards, L.S, Zee, C.T, Glynn, C, Gallagher-Jones, M, Sawaya, M.R. | 登録日 | 2021-05-29 | 公開日 | 2022-06-01 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON CRYSTALLOGRAPHY (1 Å) | 主引用文献 | Fragment-Based Ab Initio Phasing of Peptidic Nanocrystals by MicroED. Acs Bio Med Chem Au, 3, 2023
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4LTE
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![BU of 4lte by Molmil](/molmil-images/mine/4lte) | Structure of Cysteine-free Human Insulin Degrading Enzyme in Complex with Macrocyclic Inhibitor | 分子名称: | 2,6-DIAMINO-HEXANOIC ACID AMIDE, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, FUMARIC ACID, ... | 著者 | Foda, Z.H, Seeliger, M.A, Saghatelian, A, Liu, D.R. | 登録日 | 2013-07-23 | 公開日 | 2014-05-21 | 最終更新日 | 2024-04-24 | 実験手法 | X-RAY DIFFRACTION (2.705 Å) | 主引用文献 | Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones. Nature, 511, 2014
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4MDQ
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![BU of 4mdq by Molmil](/molmil-images/mine/4mdq) | Structure of a novel submicromolar MDM2 inhibitor | 分子名称: | 3-[(1R)-2-(benzylamino)-1-{[(2S)-1-(hydroxyamino)-4-methyl-1-oxopentan-2-yl]amino}-2-oxoethyl]-6-chloro-N-hydroxy-1H-indole-2-carboxamide, E3 ubiquitin-protein ligase Mdm2 | 著者 | Bista, M, Popowicz, G, Holak, T.A. | 登録日 | 2013-08-23 | 公開日 | 2013-11-13 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.119 Å) | 主引用文献 | Transient Protein States in Designing Inhibitors of the MDM2-p53 Interaction. Structure, 21, 2013
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4MFA
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![BU of 4mfa by Molmil](/molmil-images/mine/4mfa) | Structure of human DNA polymerase beta complexed with nicked DNA containing a mismatched template O6MG and incoming TTP | 分子名称: | DNA polymerase beta, MAGNESIUM ION, PHOSPHATE ION, ... | 著者 | Koag, M.C, Min, K, Monzingo, A.F, Lee, S. | 登録日 | 2013-08-27 | 公開日 | 2014-08-27 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | 主引用文献 | Structures of human DNA polymerase beta inserting bases opposite templating O6MG To be Published
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4MI0
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![BU of 4mi0 by Molmil](/molmil-images/mine/4mi0) | Human Enhancer of Zeste (Drosophila) Homolog 2(EZH2) | 分子名称: | Histone-lysine N-methyltransferase EZH2, UNKNOWN ATOM OR ION, ZINC ION | 著者 | Dong, A, Zeng, H, He, H, Wernimont, A, Bountra, C, Arrowsmith, C.H, Edwards, A.M, Brown, P.J, Wu, H, Structural Genomics Consortium (SGC) | 登録日 | 2013-08-30 | 公開日 | 2013-09-25 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structure of the catalytic domain of EZH2 reveals conformational plasticity in cofactor and substrate binding sites and explains oncogenic mutations. Plos One, 8, 2013
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4LOA
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![BU of 4loa by Molmil](/molmil-images/mine/4loa) | X-ray structure of the de-novo design amidase at the resolution 1.8A, Northeast Structural Genomics Consortium (NESG) Target OR398 | 分子名称: | CHLORIDE ION, DI(HYDROXYETHYL)ETHER, De-novo design amidase | 著者 | Kuzin, A, Lew, S, Vorobiev, S.M, Seetharaman, J, Sahdev, S, Xiao, R, Maglaqui, M, Kogan, S, Khersonsky, O, Everett, J.K, Acton, T.B, Montelione, G.T, Hunt, J.F, Tong, L, Northeast Structural Genomics Consortium (NESG) | 登録日 | 2013-07-12 | 公開日 | 2013-08-07 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.819 Å) | 主引用文献 | Northeast Structural Genomics Consortium Target OR398 To be Published
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4LOR
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![BU of 4lor by Molmil](/molmil-images/mine/4lor) | C1s CUB1-EGF-CUB2 in complex with a collagen-like peptide from C1q | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, Complement C1s subcomponent heavy chain, ... | 著者 | Wallis, R, Venkatraman Girija, U, Moody, P.C.E, Marshall, J.E. | 登録日 | 2013-07-13 | 公開日 | 2013-08-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis of the C1q/C1s interaction and its central role in assembly of the C1 complex of complement activation. Proc.Natl.Acad.Sci.USA, 110, 2013
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