7Y5U
 
 | | Cryo-EM structure of the monomeric human CAF1LC-H3-H4 complex | | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | | 著者 | Liu, C.P, Yu, Z.Y, Yu, C, Xu, R.M. | | 登録日 | 2022-06-17 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
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5EWR
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7UQJ
 | | Cryo-EM structure of the S. cerevisiae chromatin remodeler Yta7 hexamer bound to ATPgS and histone H3 tail in state II | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ATPase histone chaperone YTA7, Histone H3, ... | | 著者 | Wang, F, Feng, X, Li, H. | | 登録日 | 2022-04-19 | | 公開日 | 2023-02-01 | | 最終更新日 | 2024-06-12 | | 実験手法 | ELECTRON MICROSCOPY (3 Å) | | 主引用文献 | The Saccharomyces cerevisiae Yta7 ATPase hexamer contains a unique bromodomain tier that functions in nucleosome disassembly.
J.Biol.Chem., 299, 2022
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7UQI
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7UQK
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4WNN
 | | SPT16-H2A-H2B FACT HISTONE Complex | | 分子名称: | Histone H2A.1, Histone H2B.1, PHOSPHATE ION, ... | | 著者 | Kemble, D.J, Hill, C.P, Whitby, F.G, Formosa, T, McCullough, L.L. | | 登録日 | 2014-10-13 | | 公開日 | 2015-10-21 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | FACT Disrupts Nucleosome Structure by Binding H2A-H2B with Conserved Peptide Motifs.
Mol.Cell, 60, 2015
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6H4G
 | | Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site | | 分子名称: | ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE, INOSINE, Protein kinase A regulatory subunit | | 著者 | Volpato Santos, Y, Lorentzen, E, Basquin, J, Boshart, M. | | 登録日 | 2018-07-21 | | 公開日 | 2019-08-14 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (2.143517 Å) | | 主引用文献 | Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Elife, 12, 2024
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7EGP
 | | The structure of SWI/SNF-nucleosome complex | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Actin-like protein ARP9, Actin-related protein 7, ... | | 著者 | Chen, Z.C, Chen, K.J, He, Z.Y, Ye, Y.P. | | 登録日 | 2021-03-24 | | 公開日 | 2022-01-12 | | 実験手法 | ELECTRON MICROSCOPY (6.9 Å) | | 主引用文献 | Structure of the SWI/SNF complex bound to the nucleosome and insights into the functional modularity.
Cell Discov, 7, 2021
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3VQS
 | | Crystal structure of HCV NS5B RNA polymerase with a novel piperazine inhibitor | | 分子名称: | (2R)-4-(5-cyclopropyl[1,3]thiazolo[4,5-d]pyrimidin-2-yl)-N-[3-fluoro-4-(trifluoromethoxy)benzyl]-1-{[4-(trifluoromethyl)phenyl]sulfonyl}piperazine-2-carboxamide, CHLORIDE ION, RNA-directed RNA polymerase | | 著者 | Adachi, T, Doi, S, Ando, I, Sugimoto, K, Orita, T, Nomura, A, Kamada, M. | | 登録日 | 2012-03-30 | | 公開日 | 2012-08-08 | | 最終更新日 | 2024-11-20 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Preclinical Characterization of JTK-853, a Novel Nonnucleoside Inhibitor of the Hepatitis C Virus RNA-Dependent RNA Polymerase.
Antimicrob.Agents Chemother., 56, 2012
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1IRY
 | | Solution structure of the hMTH1, a nucleotide pool sanitization enzyme | | 分子名称: | hMTH1 | | 著者 | Mishima, M, Itoh, N, Sakai, Y, Kamiya, H, Nakabeppu, Y, Shirakawa, M. | | 登録日 | 2001-10-25 | | 公開日 | 2003-12-23 | | 最終更新日 | 2023-12-27 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of human MTH1, a Nudix family hydrolase that selectively degrades oxidized purine nucleoside triphosphates
J.Biol.Chem., 279, 2004
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9N9S
 | | Model of APC/C-CDC20-UBE2C from H3/H4-bound complex | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | 著者 | Skrajna, A, Bodrug, T, Brown, N.G, McGinty, R.K. | | 登録日 | 2025-02-11 | | 公開日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.
Nat Commun, 16, 2025
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9N9R
 | | Model of APC/C-CDC20-UBE2C from H2A/H2B-bound complex | | 分子名称: | Anaphase-promoting complex subunit 1, Anaphase-promoting complex subunit 10, Anaphase-promoting complex subunit 11, ... | | 著者 | Skrajna, A, Bodrug, T, Brown, N.G, McGinty, R.K. | | 登録日 | 2025-02-11 | | 公開日 | 2025-04-16 | | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | | 主引用文献 | APC/C-mediated ubiquitylation of extranucleosomal histone complexes lacking canonical degrons.
Nat Commun, 16, 2025
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5DTL
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8ABS
 | | Crystal structure of CYP109A2 from Bacillus megaterium bound with testosterone and putative ligand 4,6-dimethyloctanoic acid | | 分子名称: | (4~{S},6~{S})-4,6-dimethyloctanoic acid, Cytochrome P450, HEME B/C, ... | | 著者 | Jozwik, I.K, Rozeboom, H.J, Thunnissen, A.-M.W.H. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.
Febs J., 290, 2023
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8ABR
 | | Crystal structure of CYP109A2 from Bacillus megaterium bound with putative ligands hexanoic acid and octanoic acid | | 分子名称: | Cytochrome P450, HEME B/C, HEXANOIC ACID, ... | | 著者 | Jozwik, I.K, Rozeboom, H.J, Thunnissen, A.-M.W.H. | | 登録日 | 2022-07-04 | | 公開日 | 2023-07-12 | | 最終更新日 | 2024-02-07 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Regio- and stereoselective steroid hydroxylation by CYP109A2 from Bacillus megaterium explored by X-ray crystallography and computational modeling.
Febs J., 290, 2023
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8RUP
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5ETJ
 | | Crystal structure of purine nucleoside phosphorylase (E258D, L261A) mutant from human complexed with DADMe-ImmG and phosphate | | 分子名称: | 2-amino-7-{[(3R,4R)-3-hydroxy-4-(hydroxymethyl)pyrrolidin-1-yl]methyl}-3,5-dihydro-4H-pyrrolo[3,2-d]pyrimidin-4-one, PHOSPHATE ION, Purine nucleoside phosphorylase | | 著者 | Cameron, S.A, Suarez, J, Schramm, V.L, Almo, S.C. | | 登録日 | 2015-11-17 | | 公開日 | 2016-09-14 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Modulating Enzyme Catalysis through Mutations Designed to Alter Rapid Protein Dynamics.
J.Am.Chem.Soc., 138, 2016
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4JIT
 | | Crystal Structure of E. coli XGPRT in complex with (S)-3-(Guanin-9-yl)pyrrolidin-N-ylacetylphosphonic acid | | 分子名称: | Xanthine phosphoribosyltransferase, {2-[(3S)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)pyrrolidin-1-yl]-2-oxoethyl}phosphonic acid | | 著者 | Keough, D.T, Hockova, D, Rejman, D, Spacek, P, Vrbkova, S, Krecmerova, M, Eng, W.S, Jans, H, West, N.P, Naesens, L.M.J, de Jersey, J, Guddat, L.W. | | 登録日 | 2013-03-07 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
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8IQF
 | | Cryo-EM structure of the dimeric human CAF1-H3-H4 complex | | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | | 著者 | Liu, C.P, Yu, Z.Y, Xu, R.M. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
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8IQG
 | | Cryo-EM structure of the monomeric human CAF1-H3-H4 complex | | 分子名称: | Chromatin assembly factor 1 subunit A, Chromatin assembly factor 1 subunit B, Histone H3.1, ... | | 著者 | Liu, C.P, Yu, Z.Y, Xu, R.M. | | 登録日 | 2023-03-16 | | 公開日 | 2023-08-16 | | 最終更新日 | 2023-09-06 | | 実験手法 | ELECTRON MICROSCOPY (3.5 Å) | | 主引用文献 | Structural insights into histone binding and nucleosome assembly by chromatin assembly factor-1.
Science, 381, 2023
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6KU3
 | | Crystal structure of gibberellin 2-oxidase3 (GA2ox3)in rice | | 分子名称: | 2-OXOGLUTARIC ACID, GIBBERELLIN A4, GLYCEROL, ... | | 著者 | Takehara, S, Mikami, B, Sakuraba, S, Matsuoka, M, Ueguchi-Tanaka, M. | | 登録日 | 2019-08-30 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | | 主引用文献 | A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin.
Nat Commun, 11, 2020
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6KUN
 | | Crystal structure of dioxygenase for auxin oxidation (DAO) in rice | | 分子名称: | 1H-INDOL-3-YLACETIC ACID, 2-OXOGLUTARIC ACID, 2-oxoglutarate-dependent dioxygenase DAO, ... | | 著者 | Takehara, S, Mikami, B, Sakuraba, S, Matsuoka, M, Ueguchi-Tanaka, M. | | 登録日 | 2019-09-02 | | 公開日 | 2020-05-13 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.002 Å) | | 主引用文献 | A common allosteric mechanism regulates homeostatic inactivation of auxin and gibberellin.
Nat Commun, 11, 2020
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4JLS
 | | Crystal Structure of E. coli XGPRT in complex with (3R,4S)-4-(Guanin-9-yl)-3-hydroxypyrrolidin-1-N-ylacetylphosphonic acid | | 分子名称: | Xanthine phosphoribosyltransferase, {2-[(3S,4R)-3-(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)-4-hydroxypyrrolidin-1-yl]-2-oxoethyl}phosphonic acid | | 著者 | Keough, D.T, Hockova, D, Rejman, D, Spacek, P, Vrbkova, S, Krecmerova, M, Eng, W.S, Jans, H, West, N.P, Naesens, L.M.J, de Jersey, J, Guddat, L.W. | | 登録日 | 2013-03-12 | | 公開日 | 2014-12-24 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Inhibition of the Escherichia coli 6-oxopurine phosphoribosyltransferases by nucleoside phosphonates: potential for new antibacterial agents.
J.Med.Chem., 56, 2013
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2NQB
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8X7I
 | | Cryo-EM structures of RNF168/UbcH5c-Ub in complex with H2AK13Ub nucleosomes determined by intein-based E2-Ub-NCP conjugation strategy | | 分子名称: | DNA (147-MER), E3 ubiquitin-protein ligase RNF168, Histone H2A type 1-B/E, ... | | 著者 | Ai, H.S, Tong, Z.B, Deng, Z.H, Pan, M, Liu, L. | | 登録日 | 2023-11-24 | | 公開日 | 2024-08-07 | | 最終更新日 | 2025-06-18 | | 実験手法 | ELECTRON MICROSCOPY (3.27 Å) | | 主引用文献 | Capturing Snapshots of Nucleosomal H2A K13/K15 Ubiquitination Mediated by the Monomeric E3 Ligase RNF168
Biorxiv, 2024
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