7T2H
| CryoEM structure of mu-opioid receptor - Gi protein complex bound to lofentanil (LFT) | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | 著者 | Seven, A.B, Qu, Q, Huang, W, Robertson, M.J, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2022-12-14 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T2G
| CryoEM structure of mu-opioid receptor - Gi protein complex bound to mitragynine pseudoindoxyl (MP) | 分子名称: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Seven, A.B, Qu, Q, Robertson, M.J, Wang, H, Kobilka, B.K, Skiniotis, G. | 登録日 | 2021-12-04 | 公開日 | 2022-12-07 | 最終更新日 | 2023-02-15 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Insights into distinct signaling profiles of the mu OR activated by diverse agonists. Nat.Chem.Biol., 2022
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7T90
| Cryo-EM structure of ACh-bound M2R-Go signaling complex in S2 state | 分子名称: | ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.32 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T8X
| Cryo-EM structure of ACh-bound M2R-Go signaling complex in S1 state | 分子名称: | ACETYLCHOLINE, Antibody fragment, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T96
| Cryo-EM structure of S2 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-18 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.22 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T94
| Cryo-EM structure of S1 state ACh-bound M2R-Go signaling complex with a PAM | 分子名称: | 3-amino-5-chloro-N-cyclopropyl-4-methyl-6-[2-(4-methylpiperazin-1-yl)-2-oxoethoxy]thieno[2,3-b]pyridine-2-carboxamide, ACETYLCHOLINE, Antibody fragment, ... | 著者 | Xu, J, Wang, Q, Du, Y, Kobilka, B.K. | 登録日 | 2021-12-17 | 公開日 | 2023-01-25 | 最終更新日 | 2024-02-07 | 実験手法 | ELECTRON MICROSCOPY (3.16 Å) | 主引用文献 | Structural and dynamic insights into supra-physiological activation and allosteric modulation of a muscarinic acetylcholine receptor. Nat Commun, 14, 2023
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7T5Q
| Cryo-EM Structure of a Transition State of Arp2/3 Complex Activation | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Actin, ... | 著者 | Rebowski, G, van Eeuwen, T, Boczkowska, M, Dominguez, R. | 登録日 | 2021-12-13 | 公開日 | 2023-06-14 | 最終更新日 | 2023-08-02 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Cryo-EM structure of an Arp2/3 complex mini-branch capped by capping protein (CapZ) To Be Published
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7TYI
| Calcitonin Receptor in complex with Gs and rat amylin peptide, CT-like state | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Cao, J, Belousoff, M.J, Johnson, R.M, Wootten, D.L, Sexton, P.M. | 登録日 | 2022-02-13 | 公開日 | 2022-03-30 | 最終更新日 | 2022-04-06 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | A structural basis for amylin receptor phenotype. Science, 375, 2022
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7TUZ
| Cryo-EM structure of 7alpha,25-dihydroxycholesterol-bound EBI2/GPR183 in complex with Gi protein | 分子名称: | (2S,4aS,4bS,7R,8S,8aS,9R,10aR)-7-[(2R,3R)-7-hydroxy-3,7-dimethyloctan-2-yl]-4a,7,8-trimethyltetradecahydrophenanthrene-2,9-diol, G-protein coupled receptor 183, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Chen, H, Hung, W, Li, X. | 登録日 | 2022-02-03 | 公開日 | 2022-04-13 | 最終更新日 | 2022-07-20 | 実験手法 | ELECTRON MICROSCOPY (3.12 Å) | 主引用文献 | Structures of oxysterol sensor EBI2/GPR183, a key regulator of the immune response. Structure, 30, 2022
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7TD0
| Lysophosphatidic acid receptor 1-Gi complex bound to LPA | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (2.83 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD2
| Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.11 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD3
| Sphingosine-1-phosphate receptor 1-Gi complex bound to S1P | 分子名称: | (2S,3R,4E)-2-amino-3-hydroxyoctadec-4-en-1-yl dihydrogen phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD1
| Lysophosphatidic acid receptor 1-Gi complex bound to LPA, state a | 分子名称: | (2R)-2-hydroxy-3-(phosphonooxy)propyl (9E)-octadec-9-enoate, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (3.08 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7TD4
| Sphingosine-1-phosphate receptor 1-Gi complex bound to Siponimod | 分子名称: | 1-[[4-[(~{E})-~{N}-[[4-cyclohexyl-3-(trifluoromethyl)phenyl]methoxy]-~{C}-methyl-carbonimidoyl]-2-ethyl-phenyl]methyl]azetidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, S, Paknejad, N, Zhu, L, Kihara, Y, Ray, D, Chun, J, Liu, W, Hite, R.K, Huang, X.Y. | 登録日 | 2021-12-30 | 公開日 | 2022-02-09 | 最終更新日 | 2022-02-23 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Differential activation mechanisms of lipid GPCRs by lysophosphatidic acid and sphingosine 1-phosphate. Nat Commun, 13, 2022
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7RYC
| Oxytocin receptor (OTR) bound to oxytocin in complex with a heterotrimeric Gq protein | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(i) subunit alpha-2,Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Meyerowitz, J.G, Robertson, M.J, Skiniotis, G. | 登録日 | 2021-08-24 | 公開日 | 2022-03-09 | 最終更新日 | 2022-03-30 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | The oxytocin signaling complex reveals a molecular switch for cation dependence. Nat.Struct.Mol.Biol., 29, 2022
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7SYW
| Structure of the wt IRES eIF5B-containing 48S initiation complex, closed conformation. Structure 15(wt) | 分子名称: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.7 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYG
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 1(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.3 Å) | 主引用文献 | Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
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7SYM
| Structure of the HCV IRES bound to the 40S ribosomal subunit, head opening. Structure 7(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2024-02-28 | 実験手法 | ELECTRON MICROSCOPY (4.8 Å) | 主引用文献 | Comprehensive structural overview of the HCV IRES-mediated translation initiation pathway To Be Published
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7SYI
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 3(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.5 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYK
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 5(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2024-06-05 | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYU
| Structure of the delta dII IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYH
| Structure of the HCV IRES binding to the 40S ribosomal subunit, closed conformation. Structure 2(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA To Be Published
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7SYT
| Structure of the wt IRES w/o eIF2 48S initiation complex, closed conformation. Structure 13(wt) | 分子名称: | 18S rRNA, 40S ribosomal protein S21, 40S ribosomal protein S24, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-13 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (4.4 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYV
| Structure of the wt IRES eIF5B-containing pre-48S initiation complex, open conformation. Structure 14(wt) | 分子名称: | 18S rRNA, 40S ribosomal protein S2, 40S ribosomal protein S21, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-20 | 最終更新日 | 2023-02-01 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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7SYO
| Structure of the HCV IRES bound to the 40S ribosomal subunit, head open. Structure 9(delta dII) | 分子名称: | 18S rRNA, 40S ribosomal protein S2, HCV IRES, ... | 著者 | Brown, Z.P, Abaeva, I.S, De, S, Hellen, C.U.T, Pestova, T.V, Frank, J. | 登録日 | 2021-11-25 | 公開日 | 2022-07-27 | 最終更新日 | 2022-08-24 | 実験手法 | ELECTRON MICROSCOPY (4.6 Å) | 主引用文献 | Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES. Embo J., 41, 2022
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