4OTK
 
 | | A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form | | 分子名称: | CHLORIDE ION, MALONATE ION, Mycobacterial Enzyme Rv2971 | | 著者 | Shahine, A, Beddoe, T. | | 登録日 | 2014-02-13 | | 公開日 | 2014-05-07 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | A structural characterization of the isoniazid Mycobacterium tuberculosis drug target, Rv2971, in its unliganded form
Acta Crystallogr.,Sect.F, 70, 2014
|
|
4QBX
 | |
4PR4
 | |
4PMJ
 | | Crystal structure of a putative oxidoreductase from Sinorhizobium meliloti 1021 in complex with NADP | | 分子名称: | GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Putative oxidoreductase | | 著者 | Gasiorowska, O.A, Shabalin, I.G, Handing, K.B, Szlachta, K, Zimmerman, M.D, Hillerich, B.S, Gizzi, A, Toro, R, Bonanno, J, Seidel, R, Almo, S.C, Minor, W, New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2014-05-21 | | 公開日 | 2014-06-11 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of a putative oxidoreductase from Sinorhizobiummeliloti 1021 in complex with NADP
to be published
|
|
4PUW
 | |
4PUU
 | |
4Q7B
 | |
4Q3M
 | | Crystal structure of MGS-M4, an aldo-keto reductase enzyme from a Medee basin deep-sea metagenome library | | 分子名称: | MGS-M4, SODIUM ION, SULFATE ION | | 著者 | Stogios, P.J, Xu, X, Cui, H, Alcaide, M, Ferrer, M, Savchenko, A. | | 登録日 | 2014-04-11 | | 公開日 | 2015-02-25 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.552 Å) | | 主引用文献 | Pressure adaptation is linked to thermal adaptation in salt-saturated marine habitats.
Environ Microbiol, 17, 2015
|
|
4QX4
 | | Human Aldose Reductase complexed with a ligand with a new scaffold at 1.26 A | | 分子名称: | (3-thioxo-2,3-dihydro-5H-[1,2,4]triazino[5,6-b]indol-5-yl)acetic acid, Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Rechlin, C, Heine, A, Klebe, G. | | 登録日 | 2014-07-18 | | 公開日 | 2015-04-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.259 Å) | | 主引用文献 | Identification of novel aldose reductase inhibitors based on carboxymethylated mercaptotriazinoindole scaffold.
J.Med.Chem., 58, 2015
|
|
8HNQ
 | | The structure of a alcohol dehydrogenase AKR13B2 with NADP | | 分子名称: | 1,4,7,10,13,16-HEXAOXACYCLOOCTADECANE, GLYCEROL, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Chen, M, Yang, H, Lu, F. | | 登録日 | 2022-12-08 | | 公開日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The structure of AKR13B2
To Be Published
|
|
8I0C
 | | Crystal structure of Aldo-keto reductase 1C3 complexed with compound S0703 | | 分子名称: | 1-[4-[3,5-bis(chloranyl)phenyl]-3-fluoranyl-phenyl]cyclopropane-1-carboxylic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Jiang, J, He, S, Liu, Y, Fang, P, Sun, H. | | 登録日 | 2023-01-10 | | 公開日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | | 主引用文献 | Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
|
|
3F7J
 | | B.subtilis YvgN | | 分子名称: | NITRATE ION, POTASSIUM ION, YvgN protein | | 著者 | Zhou, Y.F, Lei, J, Liang, Y.H, Su, X.-D. | | 登録日 | 2008-11-09 | | 公開日 | 2008-11-25 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and biochemical analyses of YvgN and YtbE from Bacillus subtilis
Protein Sci., 18, 2009
|
|
3H7U
 | | Crystal structure of the plant stress-response enzyme AKR4C9 | | 分子名称: | ACETATE ION, Aldo-keto reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | White, S.A, Simpson, P.J, Ride, J.P. | | 登録日 | 2009-04-28 | | 公開日 | 2009-08-04 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress.
J.Mol.Biol., 392, 2009
|
|
8IKU
 | |
3H4G
 | | Structure of aldehyde reductase holoenzyme in complex with potent aldose reductase inhibitor Fidarestat: Implications for inhibitor binding and selectivity | | 分子名称: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, Alcohol dehydrogenase [NADP+], NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Carbone, V, El-Kabbani, O. | | 登録日 | 2009-04-20 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structure of aldehyde reductase holoenzyme in complex with the potent aldose reductase inhibitor fidarestat: implications for inhibitor binding and selectivity
J.Med.Chem., 48, 2005
|
|
2CLP
 | | Crystal structure of human aflatoxin B1 aldehyde reductase member 3 | | 分子名称: | AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 3, CALCIUM ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Debreczeni, J.E, Marsden, B.D, Johansson, C, Kavanagh, K, Guo, K, Smee, C, Gileadi, O, Turnbull, A, Papagrigoriou, E, von Delft, F, Edwards, A, Arrowsmith, C, Weigelt, J, Sundstrom, M, Oppermann, U. | | 登録日 | 2006-04-28 | | 公開日 | 2006-05-12 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Crystal Structure of Human Aflatoxin B1 Aldehyde Reductase Member 3
To be Published
|
|
2C91
 | | mouse succinic semialdehyde reductase, AKR7A5 | | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, AFLATOXIN B1 ALDEHYDE REDUCTASE MEMBER 2, GLYCEROL, ... | | 著者 | Zhu, X, Ellis, E.M, Lapthorn, A.J. | | 登録日 | 2005-12-08 | | 公開日 | 2006-02-15 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Crystal Structure of Mouse Succinic Semialdehyde Reductase Akr7A5: Structural Basis for Substrate Specificity.
Biochemistry, 45, 2006
|
|
2BGQ
 | | apo aldose reductase from barley | | 分子名称: | ALDOSE REDUCTASE, SULFATE ION | | 著者 | Olsen, J.G, Pedersen, L, Christensen, C.L, Olsen, O, Henriksen, A. | | 登録日 | 2005-01-04 | | 公開日 | 2006-06-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Barley Aldose Reductase: Structure, Cofactor Binding, and Substrate Recognition in the Aldo/Keto Reductase 4C Family.
Proteins: Struct., Funct., Bioinf., 71, 2008
|
|
2BGS
 | | HOLO ALDOSE REDUCTASE FROM BARLEY | | 分子名称: | ALDOSE REDUCTASE, BICARBONATE ION, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Olsen, J.G, Pedersen, L, Christensen, C.L, Olsen, O, Henriksen, A. | | 登録日 | 2005-01-05 | | 公開日 | 2006-06-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (1.64 Å) | | 主引用文献 | Barley Aldose Reductase: Structure, Cofactor Binding, and Substrate Recognition in the Aldo/Keto Reductase 4C Family.
Proteins: Struct., Funct., Bioinf., 71, 2008
|
|
3FJN
 | |
8JP2
 | | Crystal structure of AKR1C1 in complex with DFV | | 分子名称: | 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, Aldo-keto reductase family 1 member C1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zheng, X.H, Liu, H, Yao, Z.Q, Zhang, L.P. | | 登録日 | 2023-06-10 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Inhibition of AKR1Cs by liquiritigenin and the structural basis.
Chem.Biol.Interact., 385, 2023
|
|
8J0I
 | | Aldo-keto reductase KmAKR | | 分子名称: | NADPH-dependent alpha-keto amide reductase, SODIUM ION | | 著者 | Xu, S.Y, Zhou, L, Xu, Y, Wang, Y.J, Zheng, Y.G. | | 登録日 | 2023-04-11 | | 公開日 | 2024-04-17 | | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | | 主引用文献 | Aldo-keto reductase KmAKR from Kluyveromyces marxianus
To Be Published
|
|
8JP1
 | | Crystal structure of AKR1C3 in complex with DFV | | 分子名称: | 7-HYDROXY-2-(4-HYDROXY-PHENYL)-CHROMAN-4-ONE, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Zheng, X.H, Liu, H, Yao, Z.Q, Zhang, L.P. | | 登録日 | 2023-06-10 | | 公開日 | 2024-04-24 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Inhibition of AKR1Cs by liquiritigenin and the structural basis.
Chem.Biol.Interact., 385, 2023
|
|
3GHS
 | | Human aldose reductase in complex with NADP+ and the inhibitor IDD594. Investigation of global effects of radiation damage on protein structure. Second stage of radiation damage. | | 分子名称: | Aldose reductase, CITRIC ACID, IDD594, ... | | 著者 | Petrova, T, Ginell, S, Hazemann, I, Mitschler, A, Podjarny, A, Joachimiak, A. | | 登録日 | 2009-03-04 | | 公開日 | 2009-03-24 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1 Å) | | 主引用文献 | X-ray-radiation-induced cooperative atomic movements in protein.
J.Mol.Biol., 387, 2009
|
|
3G1R
 | | Crystal structure of human liver 5beta-reductase (AKR1D1) in complex with NADP and Finasteride. Resolution 1.70 A | | 分子名称: | (4aR,4bS,6aS,7S,9aS,9bS,11aR)-N-tert-butyl-4a,6a-dimethyl-2-oxo-2,4a,4b,5,6,6a,7,8,9,9a,9b,10,11,11a-tetradecahydro-1H-indeno[5,4-f]quinoline-7-carboxamide, 3-oxo-5-beta-steroid 4-dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | 著者 | Di Costanzo, L, Drury, J.E, Penning, T.M, Christianson, D.W. | | 登録日 | 2009-01-30 | | 公開日 | 2009-06-09 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.701 Å) | | 主引用文献 | Inhibition of human steroid 5beta-reductase (AKR1D1) by finasteride and structure of the enzyme-inhibitor complex.
J.Biol.Chem., 284, 2009
|
|
