4Q7B

Human Aldose Reductase complexed with a ligand with an IDD structure ([2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid) at 1.19 A

Summary for 4Q7B

• Entry DOI: 10.2210/pdb4q7b/pdb
• Related: 1us0 2ikj 4puu 4puw
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, [2-(benzylcarbamoyl)-5-fluorophenoxy]acetic acid, ... (4 entities in total)
• Functional Keywords: tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 36813.83

Authors

Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-04-24, release date: 2015-06-10, Last modification date: 2023-09-20)

• Primary citation: Rechlin, C.,Heine, A.,Scheer, F.,Toth, P.,Diederich, W.,Klebe, G.; Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation; To be Published,

Experimental method

X-RAY DIFFRACTION (1.19 Å)