4PUU
Human Aldose Reductase complexed with a ligand with an IDD structure (2-(2-carbamoyl-5-fluoro-phenoxy)acetic acid) at 1.14 A
Summary for 4PUU
Entry DOI | 10.2210/pdb4puu/pdb |
Related | 1us0 2ikj 4PUW |
Descriptor | Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (2-carbamoyl-5-fluorophenoxy)acetic acid, ... (4 entities in total) |
Functional Keywords | tim barrel, oxidoreductase, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm: P15121 |
Total number of polymer chains | 1 |
Total formula weight | 36854.91 |
Authors | Rechlin, C.,Heine, A.,Klebe, G. (deposition date: 2014-03-14, release date: 2015-04-08, Last modification date: 2023-09-20) |
Primary citation | Rechlin, C.,Heine, A.,Scheer, F.,Toth, P.,Diederich, W.,Klebe, G. Human Aldose Reductase: How expensive is the opening of the specificity pocket? IDD ligands under investigation To be Published, |
Experimental method | X-RAY DIFFRACTION (1.14 Å) |
Structure validation
Download full validation report