PDB: 717 件ウェブページステータス検索Chemie searchBIRD

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1AAX	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH TWO BIS(PARA-PHOSPHOPHENYL)METHANE (BPPM) MOLECULES 分子名称: 4-PHOSPHONOOXY-PHENYL-METHYL-[4-PHOSPHONOOXY]BENZEN, MAGNESIUM ION, PROTEIN TYROSINE PHOSPHATASE 1B 著者 Puius, Y.A, Zhao, Y, Sullivan, M, Lawrence, D, Almo, S.C, Zhang, Z.-Y. 登録日 1997-01-16 公開日 1998-03-04 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design. Proc.Natl.Acad.Sci.USA, 94, 1997
1BZJ	Human ptp1b complexed with tpicooh 分子名称: 6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) 著者 Groves, M.R, Yao, Z.-J, Barford Jr, D.T.B. 登録日 1998-10-29 公開日 1999-02-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.25 Å) 主引用文献 Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1BZC	HUMAN PTP1B CATALYTIC DOMAIN COMPLEXED WITH TPI 分子名称: 4-CARBAMOYL-4-{[6-(DIFLUORO-PHOSPHONO-METHYL)-NAPHTHALENE-2-CARBONYL]-AMINO}-BUTYRIC ACID, PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE) 著者 Groves, M.R, Yao, Z.J, Jr Burke, T.R, Barford, D. 登録日 1998-10-27 公開日 1999-02-16 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1A5Y	PROTEIN TYROSINE PHOSPHATASE 1B CYSTEINYL-PHOSPHATE INTERMEDIATE 分子名称: PROTEIN TYROSINE PHOSPHATASE 1B 著者 Pannifer, A.D.P, Flint, A.J, Tonks, N.K, Barford, D. 登録日 1998-02-19 公開日 1998-06-17 最終更新日 2023-08-02 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Visualization of the cysteinyl-phosphate intermediate of a protein-tyrosine phosphatase by x-ray crystallography. J.Biol.Chem., 273, 1998
1C87	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID 分子名称: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. 登録日 2000-04-16 公開日 2000-05-03 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
1C85	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-BENZOIC ACID 分子名称: 2-(OXALYL-AMINO)-BENZOIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. 登録日 2000-04-16 公開日 2000-05-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.72 Å) 主引用文献 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1C88	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID 分子名称: 2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]PYRIDINE-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. 登録日 2000-04-16 公開日 2000-05-03 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
1C83	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID 分子名称: 6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. 登録日 2000-04-14 公開日 2000-05-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1C84	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B COMPLEXED WITH 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXLIC ACID 分子名称: 3-(OXALYL-AMINO)-NAPHTHALENE-2-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Andersen, H.S, Iversen, L.F, Branner, S, Rasmussen, H.B, Moller, N.P. 登録日 2000-04-14 公開日 2000-05-03 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (2.35 Å) 主引用文献 2-(oxalylamino)-benzoic acid is a general, competitive inhibitor of protein-tyrosine phosphatases. J.Biol.Chem., 275, 2000
1BZH	Cyclic peptide inhibitor of human PTP1B 分子名称: PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B INHIBITOR), PROTEIN (PROTEIN-TYROSINE-PHOSPHATASE 1B) 著者 Groves, M.R, Yao, Z.J, Burke Jr, T.R, Barford, D. 登録日 1998-10-28 公開日 1999-02-16 最終更新日 2023-11-15 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Structural basis for inhibition of the protein tyrosine phosphatase 1B by phosphotyrosine peptide mimetics. Biochemistry, 37, 1998
1C86	CRYSTAL STRUCTURE OF PROTEIN TYROSINE PHOSPHATASE 1B (R47V,D48N) COMPLEXED WITH 2-(OXALYL-AMINO-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID 分子名称: 2-(OXALYL-AMINO)-4,7-DIHYDRO-5H-THIENO[2,3-C]PYRAN-3-CARBOXYLIC ACID, PROTEIN (PROTEIN-TYROSINE PHOSPHATASE 1B) 著者 Iversen, L.F, Andersen, H.S, Mortensen, S.B, Moller, N.P. 登録日 2000-04-16 公開日 2000-05-03 最終更新日 2023-08-09 実験手法 X-RAY DIFFRACTION (2.3 Å) 主引用文献 Structure-based design of a low molecular weight, nonphosphorus, nonpeptide, and highly selective inhibitor of protein-tyrosine phosphatase 1B. J.Biol.Chem., 275, 2000
4NND	Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites 分子名称: Receptor tyrosine-protein kinase erbB-2, Tyrosine-protein phosphatase non-receptor type 18 著者 Wang, H, Yang, F, Yang, D, Du, Y. 登録日 2013-11-17 公開日 2014-11-19 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (2.502 Å) 主引用文献 Structural basis of PTPN18 fingerprint on distinct HER2 tyrosine phosphorylation sites To be Published
4GE6	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 7 分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithyl-3-{[(4-hydroxy-3-methoxyphenyl)acetyl]amino}-D-alaninamide, Tyrosine-protein phosphatase non-receptor type 9 著者 Zhang, Z.-Y, Liu, S, Zhang, S. 登録日 2012-08-01 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GE2	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 3 分子名称: N-acetyl-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 著者 Zhang, Z.-Y, Liu, S, Zhang, S. 登録日 2012-08-01 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GFU	PTPN18 in complex with HER2-pY1248 phosphor-peptides 分子名称: HER2-pY1248 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 著者 Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. 登録日 2012-08-04 公開日 2013-08-07 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 PTPN18-HER2 peptides To be Published
4GE5	Crystal structure of human protein tyrosine phosphatase PTPN9 (MEG2) complex with compound 5 分子名称: N-(4-bromo-3-methylbenzoyl)-4-[difluoro(phosphono)methyl]-L-phenylalanyl-N~5~-(3-iodobenzoyl)-L-ornithinamide, Tyrosine-protein phosphatase non-receptor type 9 著者 Zhang, Z.-Y, Liu, S, Zhang, S. 登録日 2012-08-01 公開日 2012-10-31 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 A Highly Selective and Potent PTP-MEG2 Inhibitor with Therapeutic Potential for Type 2 Diabetes. J.Am.Chem.Soc., 134, 2012
4GRZ	Crystal structure of SHP1 catalytic domain with PO4 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 著者 Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. 登録日 2012-08-27 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.3732 Å) 主引用文献 Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GS0	Crystal structure of SHP1 catalytic domain with JAK1 activation loop peptide 分子名称: Tyrosine-protein kinase JAK1, Tyrosine-protein phosphatase non-receptor type 6 著者 Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. 登録日 2012-08-27 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.7961 Å) 主引用文献 Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4GFV	PTPN18 in complex with HER2-pY1196 phosphor-peptides 分子名称: HER2-pY1196 phosphor-peptide, Tyrosine-protein phosphatase non-receptor type 18 著者 Wang, H.M, Yang, F, Du, Y.J, Yang, D.X, Zhang, Y, Yu, X, Sun, J.P. 登録日 2012-08-04 公開日 2013-10-23 最終更新日 2023-12-06 実験手法 X-RAY DIFFRACTION (2.095 Å) 主引用文献 PTPN18-HER2 peptides To be Published
4GRY	Crystal structure of SHP1 catalytic domain with SO4 分子名称: SULFATE ION, Tyrosine-protein phosphatase non-receptor type 6 著者 Alicea-Velazquez, N.L, Jakoncic, J, Boggon, T.J. 登録日 2012-08-27 公開日 2012-12-19 最終更新日 2023-09-13 実験手法 X-RAY DIFFRACTION (1.6998 Å) 主引用文献 Structure-guided studies of the SHP-1/JAK1 interaction provide new insights into phosphatase catalytic domain substrate recognition. J.Struct.Biol., 181, 2013
4QBE	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X. 登録日 2014-05-08 公開日 2014-12-24 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (2.292 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57C, 2014
4QBW	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. 登録日 2014-05-08 公開日 2015-02-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.912 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014
4HJQ	SHP-1 catalytic domain WPD loop closed 分子名称: PHOSPHATE ION, Tyrosine-protein phosphatase non-receptor type 6 著者 Alicea-Velazquez, N.L, Boggon, T.J. 登録日 2012-10-13 公開日 2013-04-03 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (1.8013 Å) 主引用文献 SHP Family Protein Tyrosine Phosphatases Adopt Canonical Active-Site Conformations in the Apo and Phosphate-Bound States. Protein Pept.Lett., 20, 2013
4PVG	Crystal structure of protein tyrosine phosphatase Shp2 catalytic domain complex with small molecular compound L88N79 分子名称: 2-[3-({4-[(1,3-benzodioxol-5-ylmethyl)amino]-4-oxobutanoyl}amino)phenyl]-6-hydroxy-3-iodo-1-methyl-1H-indole-5-carboxylic acid, Tyrosine-protein phosphatase non-receptor type 11 著者 Zhang, Z.-Y, Zeng, L, Liu, D, Yu, Z. 登録日 2014-03-17 公開日 2015-04-15 最終更新日 2023-09-20 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Crystal structure of protein tyrosine Shp2 catalytic domain complex with compound L88N79 To be Published
4QAP	The second sphere residue T263 is important for function and activity of PTP1B through modulating WPD loop 分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase non-receptor type 1 著者 Xiao, P, Wang, X, Wang, H.M, Fu, X.L, Cui, F.A, Yu, X, Bi, W.X, Sun, J.P. 登録日 2014-05-05 公開日 2015-02-11 最終更新日 2024-03-20 実験手法 X-RAY DIFFRACTION (1.903 Å) 主引用文献 The second-sphere residue T263 is important for the function and catalytic activity of PTP1B via interaction with the WPD-loop Int.J.Biochem.Cell Biol., 57, 2014

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