PDB: 594 件ウェブページステータス検索Chemie searchBIRD

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2L4K	Water refined solution structure of the human Grb7-SH2 domain in complex with the 10 amino acid peptide pY1139 分子名称: Growth factor receptor-bound protein 7, Receptor tyrosine-protein kinase erbB-2 著者 Pias, S.C, Ivancic, M, Brescia, P.J, Johnson, D.L, Smith, D.E, Daly, R.J, Lyons, B.A. 登録日 2010-10-07 公開日 2010-11-17 最終更新日 2012-10-03 実験手法 SOLUTION NMR 主引用文献 Water-Refined Solution Structure of the Human Grb7-SH2 Domain in Complex with the erbB2 Receptor Peptide pY1139. Protein Pept.Lett., 19, 2012
1IS0	Crystal Structure of a Complex of the Src SH2 Domain with Conformationally Constrained Peptide Inhibitor 分子名称: AY0 GLU GLU ILE peptide, Tyrosine-protein kinase transforming protein SRC 著者 Davidson, J.P, Lubman, O, Rose, T, Waksman, G, Martin, S.F. 登録日 2001-11-02 公開日 2002-02-06 最終更新日 2023-12-27 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding. J.Am.Chem.Soc., 124, 2002
1IJR	Crystal structure of LCK SH2 complexed with nonpeptide phosphotyrosine mimetic 分子名称: (4-{2-ACETYLAMINO-2-[1-(3-CARBAMOYL-4-CYCLOHEXYLMETHOXY-PHENYL)-ETHYLCARBAMOYL}-ETHYL}-2-PHOSPHONO-PHENOXY)-ACETIC ACID, PROTO-ONCOGENE TYROSINE-PROTEIN KINASE LCK 著者 Kawahata, N.H, Yang, M.H, Luke, G.P, Shakespeare, W.C, Sundaramoorthi, R. 登録日 2001-04-27 公開日 2002-05-01 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.2 Å) 主引用文献 A novel phosphotyrosine mimetic 4'-carboxymethyloxy-3'-phosphonophenylalanine (Cpp): exploitation in the design of nonpeptide inhibitors of pp60(Src) SH2 domain. Bioorg.Med.Chem.Lett., 11, 2001
1JYQ	Xray Structure of Grb2 SH2 Domain Complexed with a Highly Affine Phospho Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, mAZ-pY-(alpha Me)pY-N-NH2 peptide inhibitor 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2018-04-04 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1KA7	SAP/SH2D1A bound to peptide n-Y-c 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-Y-c 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2024-05-22 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KA6	SAP/SH2D1A bound to peptide n-pY 分子名称: SH2 DOMAIN PROTEIN 1A, peptide n-pY 著者 Hwang, P.M, Li, C, Morra, M, Lillywhite, J, Gertler, F, Terhorst, C, Kay, L.E, Pawson, T, Forman-Kay, J, Li, S.-C. 登録日 2001-10-31 公開日 2001-11-07 最終更新日 2021-10-27 実験手法 SOLUTION NMR 主引用文献 A "three-pronged" binding mechanism for the SAP/SH2D1A SH2 domain: structural basis and relevance to the XLP syndrome. EMBO J., 21, 2002
1KC2	structure of the triple (Lys(beta)D3Ala, Asp(beta)C8Ala, AspCD2Ala) mutant of the Src SH2 domain bound to the PQpYEEIPI peptide 分子名称: COBALT (II) ION, PQpYEEIPI peptide, Src Tyrosine kinase 著者 Lubman, O.Y, Waksman, G. 登録日 2001-11-07 公開日 2002-04-17 最終更新日 2021-11-10 実験手法 X-RAY DIFFRACTION (2.1 Å) 主引用文献 Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface. J.Mol.Biol., 316, 2002
1JYR	Xray Structure of Grb2 SH2 Domain Complexed with a Phosphorylated Peptide 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2, peptide: PSpYVNVQN 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2018-10-10 実験手法 X-RAY DIFFRACTION (1.55 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1LKK	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE (PYEEI PEPTIDE) 分子名称: ACETYL GROUP, HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-ILE 著者 Tong, L. 登録日 1995-11-10 公開日 1996-03-08 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1 Å) 主引用文献 Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1I3Z	MURINE EAT2 SH2 DOMAIN IN COMPLEX WITH SLAM PHOSPHOPEPTIDE 分子名称: EWS/FLI1 ACTIVATED TRANSCRIPT 2, SIGNALING LYMPHOCYTIC ACTIVATION MOLECULE 著者 Lu, J, Poy, F, Morra, M, Terhorst, C, Eck, M.J. 登録日 2001-02-19 公開日 2003-04-08 最終更新日 2024-04-03 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Structural basis for the interaction of the free SH2 domain EAT-2 with SLAM receptors in hematopoietic cells. Eur.J.Biochem., 20, 2001
1LKL	HUMAN P56-LCK TYROSINE KINASE SH2 DOMAIN IN COMPLEX WITH THE PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY (PYEEG PEPTIDE) 分子名称: HUMAN P56 TYROSINE KINASE, PHOSPHOTYROSYL PEPTIDE AC-PTYR-GLU-GLU-GLY 著者 Tong, L. 登録日 1995-11-10 公開日 1996-03-08 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Crystal structures of the human p56lck SH2 domain in complex with two short phosphotyrosyl peptides at 1.0 A and 1.8 A resolution. J.Mol.Biol., 256, 1996
1JYU	Xray Structure of Grb2 SH2 Domain 分子名称: GROWTH FACTOR RECEPTOR-BOUND PROTEIN 2 著者 Nioche, P, Liu, W.-Q, Broutin, I, Charbonnier, F, Latreille, M.-T, Vidal, M, Roques, B, Garbay, C, Ducruix, A. 登録日 2001-09-13 公開日 2002-03-13 最終更新日 2024-02-07 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Crystal structures of the SH2 domain of Grb2: highlight on the binding of a new high-affinity inhibitor. J.Mol.Biol., 315, 2002
1JWO	Crystal Structure Analysis of the SH2 Domain of the Csk Homologous Kinase CHK 分子名称: Csk Homologous Kinase 著者 Murthy, T.V.S, Webster, G.D. 登録日 2001-09-04 公開日 2001-09-12 最終更新日 2023-08-16 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Recognition of the HER-2/neu Receptor by the SH2 Domain of the Csk Homologous Kinase To be Published
1LCJ	SH2 (SRC HOMOLOGY-2) DOMAIN OF HUMAN P56-LCK TYROSINE KINASE COMPLEXED WITH THE 11 RESIDUE PHOSPHOTYROSYL PEPTIDE EPQPYEEIPIYL 分子名称: P56==LCK== TYROSINE KINASE, PHOSPHOPEPTIDE EPQ(PHOSPHO)YEEIPIYL 著者 Eck, M, Harrison, S. 登録日 1994-12-12 公開日 1995-10-15 最終更新日 2024-06-05 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Recognition of a high-affinity phosphotyrosyl peptide by the Src homology-2 domain of p56lck. Nature, 362, 1993
1LUI	NMR Structures of Itk SH2 domain, Pro287cis isoform, ensemble of 20 low energy structures 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.M. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUN	NMR Structure of the Itk SH2 domain, Pro287trans, energy minimized average structure 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1LUK	NMR Structure of the Itk SH2 domain, Pro287cis, Energy minimized average structure 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, B.F, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
1M61	Crystal structure of the apo SH2 domains of ZAP-70 分子名称: PHOSPHATE ION, TYROSINE-PROTEIN KINASE ZAP-70 著者 Folmer, R.H.A, Geschwindner, S, Xue, Y. 登録日 2002-07-11 公開日 2003-07-15 最終更新日 2024-02-14 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure and NMR studies of the apo SH2 domains of ZAP-70: two bikes rather than a tandem Biochemistry, 41, 2002
1LUM	NMR Structure of the Itk SH2 domain, Pro287trans, 20 low energy structures 分子名称: Tyrosine-protein kinase ITK/TSK 著者 Mallis, R.J, Brazin, K.N, Fulton, D.B, Andreotti, A.H. 登録日 2002-05-22 公開日 2002-11-27 最終更新日 2022-02-23 実験手法 SOLUTION NMR 主引用文献 Structural characterization of a proline-driven conformational switch within the Itk SH2 domain Nat.Struct.Biol., 9, 2002
2CR4	Solution structure of the SH2 domain of human SH3BP2 protein 分子名称: SH3 domain-binding protein 2 著者 Hatta, R, Tomizawa, T, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2005-05-20 公開日 2005-11-20 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SH2 domain of human SH3BP2 protein To be Published
2DX0	Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 分子名称: Phospholipase C, gamma 2, SULFATE ION 著者 Handa, N, Takagi, T, Murayama, K, Terada, T, Shirouzu, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-08-22 公開日 2007-09-04 最終更新日 2011-07-13 実験手法 X-RAY DIFFRACTION (2.5 Å) 主引用文献 Crystal structure of the N-terminal SH2 domain of mouse phospholipase C-gamma 2 To be Published
2DM0	Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK 分子名称: Tyrosine-protein kinase TXK 著者 Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-20 公開日 2006-10-20 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SH2 domain of human Tyrosine-protein kinase TXK To be Published
2DLZ	Solution structure of the SH2 domain of human protein vav-2 分子名称: Protein vav-2 著者 Endo, H, Hayashi, F, Yoshida, M, Yokoyama, S, RIKEN Structural Genomics/Proteomics Initiative (RSGI) 登録日 2006-04-20 公開日 2007-04-03 最終更新日 2024-05-29 実験手法 SOLUTION NMR 主引用文献 Solution structure of the SH2 domain of human protein vav-2 To be Published
2CIA	human nck2 sh2-domain in complex with a decaphosphopeptide from translocated intimin receptor (tir) of epec 分子名称: (4S)-2-METHYL-2,4-PENTANEDIOL, CYTOPLASMIC PROTEIN NCK2, ISOPROPYL ALCOHOL, ... 著者 Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. 登録日 2006-03-17 公開日 2006-04-24 最終更新日 2024-05-01 実験手法 X-RAY DIFFRACTION (1.45 Å) 主引用文献 The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006
2CI8	sh2 domain of human nck1 adaptor protein - uncomplexed 分子名称: CYTOPLASMIC PROTEIN NCK1, PENTAETHYLENE GLYCOL, SULFATE ION 著者 Frese, S, Schubert, W.-D, Findeis, A.C, Marquardt, T, Roske, Y.S, Stradal, T.E.B, Heinz, D.W. 登録日 2006-03-17 公開日 2006-04-24 最終更新日 2023-12-13 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 The Phosphotyrosine Peptide Binding Specificity of Nck1 and Nck2 Src Homology 2 Domains. J.Biol.Chem., 281, 2006

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