6FNU
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![BU of 6fnu by Molmil](/molmil-images/mine/6fnu) | Structure of S. cerevisiae Methylenetetrahydrofolate reductase 1, catalytic domain | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Methylenetetrahydrofolate reductase 1 | 著者 | Kopec, J, Rembeza, E, Bezerra, G.A, Newman, J, Bountra, C, Froese, D.S, Baumgartner, M, Yue, W.W, Structural Genomics Consortium (SGC) | 登録日 | 2018-02-05 | 公開日 | 2018-03-07 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | Structural basis for the regulation of human 5,10-methylenetetrahydrofolate reductase by phosphorylation and S-adenosylmethionine inhibition. Nat Commun, 9, 2018
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2BX7
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![BU of 2bx7 by Molmil](/molmil-images/mine/2bx7) | Crystal structure of L. lactis dihydroorotate dehydrogense A in complex with 3,5-dihydroxybenzoate | 分子名称: | 3,5-DIHYDROXYBENZOATE, ACETATE ION, DIHYDROOROTATE DEHYDROGENASE, ... | 著者 | Wolfe, A.E, Hansen, M, Gattis, S.G, Hu, Y.-C, Johansson, E, Arent, S, Larsen, S, Palfey, B.A. | 登録日 | 2005-07-25 | 公開日 | 2006-08-29 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.04 Å) | 主引用文献 | Interaction of Benzoate Pyrimidine Analogues with Class 1A Dihydroorotate Dehydrogenase from Lactococcus Lactis. Biochemistry, 46, 2007
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6VMV
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7JSW
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![BU of 7jsw by Molmil](/molmil-images/mine/7jsw) | |
1FHW
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![BU of 1fhw by Molmil](/molmil-images/mine/1fhw) | Structure of the pleckstrin homology domain from GRP1 in complex with inositol(1,3,4,5,6)pentakisphosphate | 分子名称: | GUANINE NUCLEOTIDE EXCHANGE FACTOR AND INTEGRIN BINDING PROTEIN HOMOLOG GRP1, INOSITOL-(1,3,4,5,6)-PENTAKISPHOSPHATE, SULFATE ION | 著者 | Ferguson, K.M, Kavran, J.M, Sankaran, V.G, Fournier, E, Isakoff, S.J, Skolnik, E.Y, Lemmon, M.A. | 登録日 | 2000-08-02 | 公開日 | 2000-08-23 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structural basis for discrimination of 3-phosphoinositides by pleckstrin homology domains Mol.Cell, 6, 2000
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8DHU
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![BU of 8dhu by Molmil](/molmil-images/mine/8dhu) | Crystal structure of LARP-DM15 from Drosophila melanogaster bound to m7GpppC | 分子名称: | La-related protein 1, MAGNESIUM ION, [[(2~{R},3~{S},4~{R},5~{R})-5-(2-azanyl-7-methyl-6-oxidanylidene-1~{H}-purin-9-ium-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [[(2~{R},3~{S},4~{R},5~{R})-5-(4-azanyl-2-oxidanylidene-pyrimidin-1-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] hydrogen phosphate | 著者 | Nguyen, E, Berman, A.J. | 登録日 | 2022-06-28 | 公開日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.295 Å) | 主引用文献 | Comparative analysis of the LARP1 C-terminal DM15 region through Coelomate evolution To Be Published
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8DIO
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1FN4
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![BU of 1fn4 by Molmil](/molmil-images/mine/1fn4) | CRYSTAL STRUCTURE OF FAB198, AN EFFICIENT PROTECTOR OF ACETYLCHOLINE RECEPTOR AGAINST MYASTHENOGENIC ANTIBODIES | 分子名称: | MONOCLONAL ANTIBODY AGAINST ACETYLCHOLINE RECEPTOR | 著者 | Poulas, K, Eliopoulos, E, Vatzaki, E, Navaza, J, Kontou, M. | 登録日 | 2000-08-21 | 公開日 | 2001-09-26 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Crystal structure of Fab198, an efficient protector of the acetylcholine receptor against myasthenogenic antibodies. Eur.J.Biochem., 268, 2001
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6FQN
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![BU of 6fqn by Molmil](/molmil-images/mine/6fqn) | Carbamylated T. californica acetylcholineterase bound to uncharged hybrid reactivator 2 | 分子名称: | 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-[4-[(7-chloranyl-1,2,3,4-tetrahydroacridin-9-yl)amino]butyl]-2-[(oxidanylamino)methyl]pyridin-3-ol, ... | 著者 | De la Mora, E, Santoni, G, de Souza, J, Sussman, J, Silman, I, Baati, R, Weik, M, Nachon, F. | 登録日 | 2018-02-14 | 公開日 | 2018-08-29 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (2.30002666 Å) | 主引用文献 | Structure-Based Optimization of Nonquaternary Reactivators of Acetylcholinesterase Inhibited by Organophosphorus Nerve Agents. J. Med. Chem., 61, 2018
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7BV0
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![BU of 7bv0 by Molmil](/molmil-images/mine/7bv0) | HEV-C E2s | 分子名称: | Protein ORF2 | 著者 | Bai, C.Z, Qi, J.X. | 登録日 | 2020-04-08 | 公開日 | 2020-05-06 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Structure of emerging human-infected hepatitis E virus E2s at 1.8 Angstroms resolution To Be Published
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7TUE
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![BU of 7tue by Molmil](/molmil-images/mine/7tue) | Crystal structure of Tapasin in complex with HLA-B*44:05 (T73C) | 分子名称: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B alpha chain, ... | 著者 | Jiang, J, Natarajan, K, Kim, E, Boyd, L.F, Margulies, D.H. | 登録日 | 2022-02-02 | 公開日 | 2022-09-07 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | 主引用文献 | Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation. Nat Commun, 13, 2022
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6VZI
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8C9W
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![BU of 8c9w by Molmil](/molmil-images/mine/8c9w) | Crystal structure of the adenosine A2A receptor (construct A2A-PSB2-bRIL) complexed with Etrumadenant at the orthosteric pocket | 分子名称: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 3-[2-azanyl-6-[1-[[6-(2-oxidanylpropan-2-yl)pyridin-2-yl]methyl]-1,2,3-triazol-4-yl]pyrimidin-4-yl]-2-methyl-benzenecarbonitrile, ... | 著者 | Strater, N, Claff, T, Schlegel, J.G, Voss, J.H, Vaassen, V, Muller, C.E. | 登録日 | 2023-01-23 | 公開日 | 2023-07-12 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.114 Å) | 主引用文献 | Crystal structure of adenosine A 2A receptor in complex with clinical candidate Etrumadenant reveals unprecedented antagonist interaction. Commun Chem, 6, 2023
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2BPQ
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![BU of 2bpq by Molmil](/molmil-images/mine/2bpq) | Anthranilate phosphoribosyltransferase (TrpD) from Mycobacterium tuberculosis (Apo structure) | 分子名称: | ANTHRANILATE PHOSPHORIBOSYLTRANSFERASE, BENZAMIDINE, GLYCEROL | 著者 | Lee, C.E, Goodfellow, C, Javid-Majd, F, Baker, E.N, Lott, J.S, TB Structural Genomics Consortium (TBSGC) | 登録日 | 2005-04-22 | 公開日 | 2006-01-04 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | The Crystal Structure of Trpd, a Metabolic Enzyme Essential for Lung Colonization by Mycobacterium Tuberculosis, in Complex with its Substrate Phosphoribosylpyrophosphate J.Mol.Biol., 355, 2006
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6W7H
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![BU of 6w7h by Molmil](/molmil-images/mine/6w7h) | Co-crystal structures of CHIKV nsP3 macrodomain with pyrimidone fragments | 分子名称: | 6-methyl-2-oxo-2,5-dihydropyrimidine-4-carboxylic acid, Nonstructural polyprotein | 著者 | Zhang, S, Garzan, A, Augelli-Szafran, C.E, Pathak, A.K, Wu, M. | 登録日 | 2020-03-19 | 公開日 | 2021-01-13 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design. Plos One, 16, 2021
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6W8S
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![BU of 6w8s by Molmil](/molmil-images/mine/6w8s) | Crystal structure of metacaspase 4 from Arabidopsis | 分子名称: | Metacaspase-4, SULFATE ION | 著者 | Zhu, P, Yu, X.H, Wang, C, Zhang, Q, Liu, W, McSweeney, S, Shanklin, J, Lam, E, Liu, Q. | 登録日 | 2020-03-21 | 公開日 | 2020-05-20 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (3.484 Å) | 主引用文献 | Structural basis for Ca2+-dependent activation of a plant metacaspase. Nat Commun, 11, 2020
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1FPZ
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![BU of 1fpz by Molmil](/molmil-images/mine/1fpz) | CRYSTAL STRUCTURE ANALYSIS OF KINASE ASSOCIATED PHOSPHATASE (KAP) WITH A SUBSTITUTION OF THE CATALYTIC SITE CYSTEINE (CYS140) TO A SERINE | 分子名称: | CYCLIN-DEPENDENT KINASE INHIBITOR 3, SULFATE ION | 著者 | Song, H, Hanlon, N, Brown, N.R, Noble, M.E.M, Johnson, L.N, Barford, D. | 登録日 | 2000-09-01 | 公開日 | 2001-05-09 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Phosphoprotein-protein interactions revealed by the crystal structure of kinase-associated phosphatase in complex with phosphoCDK2. Mol.Cell, 7, 2001
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6WB8
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8C7S
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![BU of 8c7s by Molmil](/molmil-images/mine/8c7s) | Transcriptional pleiotropic repressor CodY from Staphylococcus aureus in complex with Ile, GTP, and a 30-bp DNA fragment encompassing two overlapping binding sites | 分子名称: | DNA (30-MER), GUANOSINE-5'-TRIPHOSPHATE, Global transcriptional regulator CodY (Fragment), ... | 著者 | Hainzl, T, Sauer-Eriksson, A.E. | 登録日 | 2023-01-17 | 公開日 | 2023-07-19 | 最終更新日 | 2023-11-15 | 実験手法 | X-RAY DIFFRACTION (3.05 Å) | 主引用文献 | Structural insights into CodY activation and DNA recognition. Nucleic Acids Res., 51, 2023
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721P
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![BU of 721p by Molmil](/molmil-images/mine/721p) | THREE-DIMENSIONAL STRUCTURES OF H-RAS P21 MUTANTS: MOLECULAR BASIS FOR THEIR INABILITY TO FUNCTION AS SIGNAL SWITCH MOLECULES | 分子名称: | H-RAS P21 PROTEIN, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER | 著者 | Krengel, U, Scherer, A, Kabsch, W, Wittinghofer, A, Pai, E.F. | 登録日 | 1991-06-06 | 公開日 | 1994-01-31 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Three-dimensional structures of H-ras p21 mutants: molecular basis for their inability to function as signal switch molecules. Cell(Cambridge,Mass.), 62, 1990
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3CKE
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![BU of 3cke by Molmil](/molmil-images/mine/3cke) | Crystal structure of aristolochene synthase in complex with 12,13-difluorofarnesyl diphosphate | 分子名称: | (2E,6E)-12-fluoro-11-(fluoromethyl)-3,7-dimethyldodeca-2,6,10-trien-1-yl trihydrogen diphosphate, Aristolochene synthase, BETA-MERCAPTOETHANOL, ... | 著者 | Shishova, E.Y, Yu, F, Miller, D.J, Faraldos, J.A, Zhao, Y, Coates, R.M, Allemann, R.K, Cane, D.E, Christianson, D.W. | 登録日 | 2008-03-14 | 公開日 | 2008-04-01 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | X-ray Crystallographic Studies of Substrate Binding to Aristolochene Synthase Suggest a Metal Ion Binding Sequence for Catalysis. J.Biol.Chem., 283, 2008
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2CO7
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![BU of 2co7 by Molmil](/molmil-images/mine/2co7) | Salmonella enterica SafA pilin in complex with the SafB chaperone (Type II) | 分子名称: | PUTATIVE FIMBRIAE ASSEMBLY CHAPERONE, SAFA PILUS SUBUNIT, SULFATE ION | 著者 | Remaut, H, Rose, R.J, Hannan, T.J, Hultgren, S.J, Radford, S.E, Ashcroft, A.E, Waksman, G. | 登録日 | 2006-05-25 | 公開日 | 2006-06-27 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Donor-Strand Exchange in Chaperone-Assisted Pilus Assembly Proceeds Through a Concerted Beta-Strand Displacement Mechanism Mol.Cell, 22, 2006
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5CM1
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![BU of 5cm1 by Molmil](/molmil-images/mine/5cm1) | X-ray structure of perdeuterated TTR mutant - T119M at 1.22A | 分子名称: | Transthyretin | 著者 | Yee, A.W, Moulin, M, Mossou, E, Haertlein, M, Mitchell, E.P, Cooper, J.B, Forsyth, V.T. | 登録日 | 2015-07-16 | 公開日 | 2016-07-27 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.22 Å) | 主引用文献 | X-ray structure of perdeuterated TTR mutant - T119M at 1.22A To Be Published
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6VMW
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2JCC
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![BU of 2jcc by Molmil](/molmil-images/mine/2jcc) | AH3 recognition of mutant HLA-A2 W167A | 分子名称: | BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN, A-2 ALPHA CHAIN, ... | 著者 | Miller, P, Benhar, Y.P, Biddison, W, Collins, E.J. | 登録日 | 2006-12-21 | 公開日 | 2007-10-09 | 最終更新日 | 2023-12-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Single Mhc Mutation Eliminates Enthalpy Associated with T Cell Receptor Binding. J.Mol.Biol., 373, 2007
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