7TUE

Crystal structure of Tapasin in complex with HLA-B*44:05 (T73C)

Summary for 7TUE

Entry DOI	10.2210/pdb7tue/pdb
Related	7TUC 7TUD 7TUF 7TUG 7TUH
Descriptor	HLA class I histocompatibility antigen, B alpha chain, Tapasin, Beta-2-microglobulin (3 entities in total)
Functional Keywords	tapasin, histocompatibility complex class i, mhc-i, hla, peptide editing, peptide loading complex, plc, antigen presentation, immune response, immune system
Biological source	Homo sapiens More
Total number of polymer chains	3
Total formula weight	88423.15
Authors	Jiang, J.,Natarajan, K.,Kim, E.,Boyd, L.F.,Margulies, D.H. (deposition date: 2022-02-02, release date: 2022-09-07, Last modification date: 2023-10-18)
Primary citation	Jiang, J.,Taylor, D.K.,Kim, E.J.,Boyd, L.F.,Ahmad, J.,Mage, M.G.,Truong, H.V.,Woodward, C.H.,Sgourakis, N.G.,Cresswell, P.,Margulies, D.H.,Natarajan, K. Structural mechanism of tapasin-mediated MHC-I peptide loading in antigen presentation. Nat Commun, 13:5470-5470, 2022 Cited by PubMed: 36115831 DOI: 10.1038/s41467-022-33153-8 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.1 Å)

Structure validation