8AB3
| Crystal Structure of the Lactate Dehydrogenase of Cyanobacterium Aponinum in complex with oxamate, NADH and FBP. | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1,6-di-O-phosphono-beta-D-fructofuranose, L-lactate dehydrogenase, ... | 著者 | Robin, A.Y, Girard, E, Madern, D. | 登録日 | 2022-07-04 | 公開日 | 2022-07-27 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.616 Å) | 主引用文献 | Deciphering Evolutionary Trajectories of Lactate Dehydrogenases Provides New Insights into Allostery. Mol.Biol.Evol., 40, 2023
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5MI5
| BtGH84 mutant with covalent modification by MA3 in complex with PUGNAc | 分子名称: | CALCIUM ION, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, O-GlcNAcase BT_4395, ... | 著者 | Darby, J.F, Davies, G.J, Hubbard, R.E. | 登録日 | 2016-11-27 | 公開日 | 2017-11-01 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.15 Å) | 主引用文献 | Increase of enzyme activity through specific covalent modification with fragments. Chem Sci, 8, 2017
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6B82
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8AD8
| Flavin-dependent tryptophan 6-halogenase Thal in complex with a D-Trp-Ser dipeptide | 分子名称: | D-tryptophyl-L-serine, GLYCEROL, PHOSPHATE ION, ... | 著者 | Gafe, S, Moritzer, A.C, Montua, N, Sewald, N, Niemann, H.H. | 登録日 | 2022-07-08 | 公開日 | 2022-10-12 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | 主引用文献 | Enzymatic Late-Stage Halogenation of Peptides. Chembiochem, 24, 2023
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8CVN
| Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415 | 分子名称: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine | 著者 | Huang, W, Taylor, D.J. | 登録日 | 2022-05-18 | 公開日 | 2023-03-01 | 最終更新日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.4 Å) | 主引用文献 | Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14, 2023
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8B26
| Dihydroprecondylocarpine acetate synthase 2 from Tabernanthe iboga | 分子名称: | Dihydroprecondylocarpine acetate synthase 2, ZINC ION | 著者 | Langley, C, Basquin, J, Caputi, L, O'Connor, S.E. | 登録日 | 2022-09-13 | 公開日 | 2022-10-19 | 最終更新日 | 2024-01-31 | 実験手法 | X-RAY DIFFRACTION (2.42 Å) | 主引用文献 | Expansion of the Catalytic Repertoire of Alcohol Dehydrogenases in Plant Metabolism. Angew.Chem.Int.Ed.Engl., 61, 2022
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8D1C
| Crystal structure of T252E-CYP199A4 in complex with 4-(Trifluoromethoxy)benzoic acid | 分子名称: | 4-(trifluoromethoxy)benzoic acid, CHLORIDE ION, Cytochrome P450, ... | 著者 | Lee, J.H.Z, Bruning, J.B, Bell, S.G. | 登録日 | 2022-05-27 | 公開日 | 2023-03-01 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Selective Oxidations Using a Cytochrome P450 Enzyme Variant Driven with Surrogate Oxygen Donors and Light. Chemistry, 28, 2022
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4Q73
| Crystal Structure of Bradyrhizobium japonicum Proline Utilization A (PutA) Mutant D778Y | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, Proline dehydrogenase, ... | 著者 | Tanner, J.J, Luo, M, Pemberton, T.A. | 登録日 | 2014-04-23 | 公開日 | 2014-08-06 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Kinetic and Structural Characterization of Tunnel-Perturbing Mutants in Bradyrhizobium japonicum Proline Utilization A. Biochemistry, 53, 2014
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1BP1
| CRYSTAL STRUCTURE OF BPI, THE HUMAN BACTERICIDAL PERMEABILITY-INCREASING PROTEIN | 分子名称: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, BACTERICIDAL/PERMEABILITY-INCREASING PROTEIN | 著者 | Beamer, L.J, Carroll, S.F, Eisenberg, D. | 登録日 | 1997-04-08 | 公開日 | 1997-09-04 | 最終更新日 | 2021-11-03 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Crystal structure of human BPI and two bound phospholipids at 2.4 angstrom resolution. Science, 276, 1997
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5MKP
| Non redox thiolation in transfer RNAs occuring via sulfur activation by a [4Fe-4S] cluster | 分子名称: | Fe4 H S5, PH0300, ZINC ION | 著者 | Arragain, S, Bimai, O, Legrand, P, Golinelli-Pimpaneau, B. | 登録日 | 2016-12-05 | 公開日 | 2017-06-14 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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8OVD
| Respiratory supercomplex (III2-IV2) from Mycobacterium smegmatis | 分子名称: | (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | 著者 | Kovalova, T, Krol, S, Sjostrand, D, Riepl, D, Gamiz-Hernandez, A, Brzezinski, P, Kaila, V, Hogbom, M. | 登録日 | 2023-04-25 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Long-range charge transfer mechanism of the III 2 IV 2 mycobacterial supercomplex. Nat Commun, 15, 2024
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6BG3
| Structure of (3S,4S)-1-benzyl-4-(3-(3-(trifluoromethyl)phenyl)ureido)piperidin-3-yl acetate bound to DCN1 | 分子名称: | Endolysin, DCN1-like protein 1 chimera, N-{(3S,4S)-1-benzyl-3-[(1S)-1-hydroxyethoxy]piperidin-4-yl}-N'-[3-(trifluoromethyl)phenyl]urea | 著者 | Guy, R.K, Schulman, B.A, Scott, D.C, Hammill, J.T. | 登録日 | 2017-10-27 | 公開日 | 2018-09-26 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Piperidinyl Ureas Chemically Control Defective in Cullin Neddylation 1 (DCN1)-Mediated Cullin Neddylation. J. Med. Chem., 61, 2018
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1JOB
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8AD7
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6BAG
| Lactate Dehydrogenase in complex with inhibitor (R)-5-((2-chlorophenyl)thio)-6'-((4-fluorophenyl)amino)-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro-[2,2'-bipyridin]-6(1H)-one | 分子名称: | (2R)-5-[(2-chlorophenyl)sulfanyl]-6'-[(4-fluorophenyl)amino]-4-hydroxy-2-(thiophen-3-yl)-2,3-dihydro[2,2'-bipyridin]-6(1H)-one, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, L-lactate dehydrogenase A chain, ... | 著者 | Ultsch, M, Eigenbrot, C. | 登録日 | 2017-10-12 | 公開日 | 2018-10-17 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure-guided optimization and in vivo activities of hydroxylactone and hydroxylactam Inhibitors of Human Lactate Dehydrogenase To Be Published
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8OVC
| Respiratory supercomplex (III2-IV2) from Mycobacterium smegmatis | 分子名称: | (1R)-2-(dodecanoyloxy)-1-[(phosphonooxy)methyl]ethyl tetradecanoate, (2R)-2-(hexadecanoyloxy)-3-{[(S)-hydroxy{[(1R,2R,3R,4R,5R,6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9S)-9-methyloctadecanoate, (2S)-1-(hexadecanoyloxy)propan-2-yl (10S)-10-methyloctadecanoate, ... | 著者 | Kovalova, T, Krol, S, Sjostrand, D, Riepl, D, Gamiz-Hernandez, A, Brzezinski, P, Kaila, V, Hogbom, M. | 登録日 | 2023-04-25 | 公開日 | 2024-07-17 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Long-range charge transfer mechanism of the III 2 IV 2 mycobacterial supercomplex. Nat Commun, 15, 2024
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8AE3
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 4 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | 登録日 | 2022-07-12 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (6.8 Å) | 主引用文献 | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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6BB0
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5MMT
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3NXY
| Preferential Selection of Isomer Binding from Chiral Mixtures: Alernate Binding Modes Observed fro the E- and Z-isomers of a Series of 5-Substituted 2,4-Diaminofuro[2,3-d]pyrimidines as Ternary Complexes with NADPH and Human Dihydrofolate Reductase | 分子名称: | 5-[(1E,3R)-2-(2-methoxyphenyl)-3-methylpent-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-diamine, Dihydrofolate reductase, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | 著者 | Cody, V. | 登録日 | 2010-07-14 | 公開日 | 2010-12-15 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Preferential selection of isomer binding from chiral mixtures: alternate binding modes observed for the E and Z isomers of a series of 5-substituted 2,4-diaminofuro[2,3-d]pyrimidines as ternary complexes with NADPH and human dihydrofolate reductase. Acta Crystallogr.,Sect.D, 66, 2010
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8ADZ
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | 登録日 | 2022-07-12 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (6.7 Å) | 主引用文献 | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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3W9W
| Crystal structure of DING protein | 分子名称: | DING protein, GLYCEROL, PHOSPHATE ION | 著者 | Gai, Z.Q, Nakamura, A, Tanaka, Y, Hirano, N, Tanaka, I, Yao, M. | 登録日 | 2013-04-17 | 公開日 | 2013-10-30 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure analysis, overexpression and refolding behaviour of a DING protein with single mutation. J.SYNCHROTRON RADIAT., 20, 2013
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8AE0
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 3 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | 登録日 | 2022-07-12 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (7.1 Å) | 主引用文献 | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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8ADY
| Cryo-EM structure of full-length human immunoglobulin M - F(ab')2 conformation 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, IgM C2-domain from mouse, ... | 著者 | Chen, Q, Rosenthal, P, Tolar, P. | 登録日 | 2022-07-12 | 公開日 | 2022-10-26 | 最終更新日 | 2022-11-09 | 実験手法 | ELECTRON MICROSCOPY (5.2 Å) | 主引用文献 | Cryomicroscopy reveals the structural basis for a flexible hinge motion in the immunoglobulin M pentamer. Nat Commun, 13, 2022
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5U22
| Structure of N2152 from Neocallimastix frontalis | 分子名称: | 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, IODIDE ION, ... | 著者 | Jones, D.R, Abbott, D.W. | 登録日 | 2016-11-29 | 公開日 | 2017-06-14 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (1.748 Å) | 主引用文献 | Discovery and characterization of family 39 glycoside hydrolases from rumen anaerobic fungi with polyspecific activity on rare arabinosyl substrates. J. Biol. Chem., 292, 2017
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