5MI5

BtGH84 mutant with covalent modification by MA3 in complex with PUGNAc

Summary for 5MI5

• Entry DOI: 10.2210/pdb5mi5/pdb
• Descriptor: O-GlcNAcase BT_4395, O-(2-ACETAMIDO-2-DEOXY D-GLUCOPYRANOSYLIDENE) AMINO-N-PHENYLCARBAMATE, ~{N}-(4-ethoxyquinazolin-2-yl)propanamide, ... (5 entities in total)
• Functional Keywords: hydrolase, activator
• Biological source: Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482)
• Total number of polymer chains: 1
• Total formula weight: 84240.13

Authors

Darby, J.F.,Davies, G.J.,Hubbard, R.E. (deposition date: 2016-11-27, release date: 2017-11-01, Last modification date: 2024-01-17)

• Primary citation: Darby, J.F.,Atobe, M.,Firth, J.D.,Bond, P.,Davies, G.J.,O'Brien, P.,Hubbard, R.E.; Increase of enzyme activity through specific covalent modification with fragments.; Chem Sci, 8:7772-7779, 2017; PubMed: 29163914; DOI: 10.1039/c7sc01966a

Experimental method

X-RAY DIFFRACTION (2.15 Å)