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8CVN

Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415

Summary for 8CVN
Entry DOI10.2210/pdb8cvn/pdb
EMDB information27010
Descriptor15-hydroxyprostaglandin dehydrogenase [NAD(+)], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine (3 entities in total)
Functional Keywordsdehydrogenase, inhibitor, oxidoreductase, oxidoreductase-inhibitor complex
Biological sourceHomo sapiens (human)
Total number of polymer chains2
Total formula weight57970.22
Authors
Huang, W.,Taylor, D.J. (deposition date: 2022-05-18, release date: 2023-03-01, Last modification date: 2023-03-29)
Primary citationHuang, W.,Li, H.,Kiselar, J.,Fink, S.P.,Regmi, S.,Day, A.,Yuan, Y.,Chance, M.,Ready, J.M.,Markowitz, S.D.,Taylor, D.J.
Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system.
Nat Commun, 14:784-784, 2023
Cited by
PubMed: 36774348
DOI: 10.1038/s41467-023-36463-7
PDB entries with the same primary citation
Experimental method
ELECTRON MICROSCOPY (2.4 Å)
Structure validation

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