8CVN
Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415
Summary for 8CVN
Entry DOI | 10.2210/pdb8cvn/pdb |
EMDB information | 27010 |
Descriptor | 15-hydroxyprostaglandin dehydrogenase [NAD(+)], 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine (3 entities in total) |
Functional Keywords | dehydrogenase, inhibitor, oxidoreductase, oxidoreductase-inhibitor complex |
Biological source | Homo sapiens (human) |
Total number of polymer chains | 2 |
Total formula weight | 57970.22 |
Authors | Huang, W.,Taylor, D.J. (deposition date: 2022-05-18, release date: 2023-03-01, Last modification date: 2023-03-29) |
Primary citation | Huang, W.,Li, H.,Kiselar, J.,Fink, S.P.,Regmi, S.,Day, A.,Yuan, Y.,Chance, M.,Ready, J.M.,Markowitz, S.D.,Taylor, D.J. Small molecule inhibitors of 15-PGDH exploit a physiologic induced-fit closing system. Nat Commun, 14:784-784, 2023 Cited by PubMed: 36774348DOI: 10.1038/s41467-023-36463-7 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.4 Å) |
Structure validation
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