8CVN

Cryo-EM Structure of Human 15-PGDH in Complex with Small Molecule SW209415

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	15-hydroxyprostaglandin dehydrogenase [NAD(+)]	polymer	256	27886.1	2	UniProt (P15428) Pfam (PF00106)	Homo sapiens (human)	15-PGDH,Eicosanoid/docosanoid dehydrogenase [NAD(+)],Prostaglandin dehydrogenase 1,Short chain dehydrogenase/reductase family 36C member 1
2	C, E (A, B)	1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE	non-polymer		665.4	2	Chemie (NAI)
3	D, F (A, B)	2-[butyl(oxidanyl)-$l^{3}-sulfanyl]-4-(2,3-dimethylimidazol-4-yl)-6-(1,3-thiazol-2-yl)thieno[2,3-b]pyridin-3-amine	non-polymer		433.6	2	Chemie (SWL)

Sequence modifications

A, B: 3 - 256 (UniProt: P15428)

PDB	External Database	Details
His 1	-	expression tag
Met 2	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	55772.1
Non-Polymers*	Number of molecules	4
	Total formula weight	2198.1
All*	Total formula weight	57970.2

*Water molecules are not included.