7WYS
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![BU of 7wys by Molmil](/molmil-images/mine/7wys) | Crystal structures of Na+,K+-ATPase in complex with istaroxime | 分子名称: | (3E,5S,8R,9S,10R,13S,14S)-3-(2-azanylethoxyimino)-10,13-dimethyl-1,2,4,5,7,8,9,11,12,14,15,16-dodecahydrocyclopenta[a]phenanthrene-6,17-dione, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Ogawa, H, Cornelius, F, Kanai, R, Motoyama, K, Vilsen, B, Toyoshima, C. | 登録日 | 2022-02-16 | 公開日 | 2022-05-04 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (3.71 Å) | 主引用文献 | Cryoelectron microscopy of Na + ,K + -ATPase in the two E2P states with and without cardiotonic steroids. Proc.Natl.Acad.Sci.USA, 119, 2022
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7X22
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![BU of 7x22 by Molmil](/molmil-images/mine/7x22) | Cryo-EM structure of non gastric H,K-ATPase alpha2 K794S in (2K+)E2-AlF state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Nakanishi, H, Abe, K. | 登録日 | 2022-02-25 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms. Nat Commun, 13, 2022
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7ULC
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![BU of 7ulc by Molmil](/molmil-images/mine/7ulc) | Crystal structure of queuine salvage enzyme DUF2419 mutant D231N, in complex with queuosine-5'-monophosphate | 分子名称: | 2-amino-5-({[(1S,4S,5R)-4,5-dihydroxycyclopent-2-en-1-yl]amino}methyl)-7-(5-O-phosphono-beta-D-ribofuranosyl)-3,7-dihydro-4H-pyrrolo[2,3-d]pyrimidin-4-one, DI(HYDROXYETHYL)ETHER, Queuosine salvage protein DUF2419 | 著者 | Hung, S.-H, Swairjo, M.A. | 登録日 | 2022-04-04 | 公開日 | 2022-12-21 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.99 Å) | 主引用文献 | Structural basis of Qng1-mediated salvage of the micronutrient queuine from queuosine-5'-monophosphate as the biological substrate. Nucleic Acids Res., 51, 2023
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7X24
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![BU of 7x24 by Molmil](/molmil-images/mine/7x24) | Cryo-EM structure of non gastric H,K-ATPase alpha2 SPWC mutant in (2K+)E2-AlF state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Abe, K, Nakanishi, H, Young, V, Artigas, P. | 登録日 | 2022-02-25 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (3.4 Å) | 主引用文献 | Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms. Nat Commun, 13, 2022
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7X21
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![BU of 7x21 by Molmil](/molmil-images/mine/7x21) | Cryo-EM structure of non gastric H,K-ATPase alpha2 K794A in (K+)E2-AlF state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, ... | 著者 | Nakanishi, H, Abe, K. | 登録日 | 2022-02-25 | 公開日 | 2022-10-05 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Structure and function of H + /K + pump mutants reveal Na + /K + pump mechanisms. Nat Commun, 13, 2022
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7Y45
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![BU of 7y45 by Molmil](/molmil-images/mine/7y45) | Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C. | 登録日 | 2022-06-14 | 公開日 | 2022-07-13 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (3.3 Å) | 主引用文献 | Cryo-electron microscopy of Na + ,K + -ATPase reveals how the extracellular gate locks in the E2·2K + state. Febs Lett., 596, 2022
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7Y46
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![BU of 7y46 by Molmil](/molmil-images/mine/7y46) | Cryo-EM structure of the Na+,K+-ATPase in the E2.2K+ state after addition of ATP | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Kanai, R, Cornelius, F, Vilsen, B, Toyoshima, C. | 登録日 | 2022-06-14 | 公開日 | 2022-07-13 | 最終更新日 | 2022-10-19 | 実験手法 | ELECTRON MICROSCOPY (7.2 Å) | 主引用文献 | Cryo-electron microscopy of Na + ,K + -ATPase reveals how the extracellular gate locks in the E2·2K + state. Febs Lett., 596, 2022
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7Y7Z
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![BU of 7y7z by Molmil](/molmil-images/mine/7y7z) | Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ... | 著者 | Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C. | 登録日 | 2022-06-22 | 公開日 | 2023-04-26 | 最終更新日 | 2023-11-29 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Molecular basis for substrate recognition and transport of human GABA transporter GAT1. Nat.Struct.Mol.Biol., 30, 2023
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8TKF
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![BU of 8tkf by Molmil](/molmil-images/mine/8tkf) | Human Type 3 IP3 Receptor - Activated State (+IP3/ATP/JD Ca2+) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | 登録日 | 2023-07-25 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
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8TKG
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![BU of 8tkg by Molmil](/molmil-images/mine/8tkg) | Human Type 3 IP3 Receptor - Resting State (+IP3/ATP) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CALCIUM ION, ... | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | 登録日 | 2023-07-25 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.5 Å) | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
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8TK8
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![BU of 8tk8 by Molmil](/molmil-images/mine/8tk8) | Human Type 3 IP3 Receptor - Resting State (+IP3/ATP) | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | 著者 | Paknejad, N, Sapuru, V, Hite, R.K. | 登録日 | 2023-07-25 | 公開日 | 2023-11-08 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Structural titration reveals Ca 2+ -dependent conformational landscape of the IP 3 receptor. Nat Commun, 14, 2023
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8THH
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![BU of 8thh by Molmil](/molmil-images/mine/8thh) | Cryo-EM structure of Nav1.7 with LTG | 分子名称: | (6M)-6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
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8THG
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![BU of 8thg by Molmil](/molmil-images/mine/8thg) | Cryo-EM structure of Nav1.7 with RLZ | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 1-O-OCTADECYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | 著者 | Fan, X, Huang, J, Yan, N. | 登録日 | 2023-07-16 | 公開日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Dual-pocket inhibition of Na v channels by the antiepileptic drug lamotrigine. Proc.Natl.Acad.Sci.USA, 120, 2023
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8F2K
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8U3A
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![BU of 8u3a by Molmil](/molmil-images/mine/8u3a) | TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 1 (monomer) | 分子名称: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, SODIUM ION, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U3C
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![BU of 8u3c by Molmil](/molmil-images/mine/8u3c) | TRPV1 in nanodisc bound with PI-Br4 bound in Conformation 2 (monomer) | 分子名称: | (2S)-2-[(9,10-dibromooctadecanoyl)oxy]-3-{[(S)-hydroxy{[(1S,2R,3R,4S,5S,6R)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propyl (9R,10S)-9,10-dibromooctadecanoate, 1,2-DIACYL-GLYCEROL-3-SN-PHOSPHATE, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-07 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (2.3 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8U2Z
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![BU of 8u2z by Molmil](/molmil-images/mine/8u2z) | TRPV1 in nanodisc bound with diC8-PIP2 in the dilated state | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL, SODIUM ION, ... | 著者 | Arnold, W.R, Julius, D, Cheng, Y. | 登録日 | 2023-09-06 | 公開日 | 2024-05-08 | 最終更新日 | 2024-05-15 | 実験手法 | ELECTRON MICROSCOPY (3.6 Å) | 主引用文献 | Structural basis of TRPV1 modulation by endogenous bioactive lipids. Nat.Struct.Mol.Biol., 2024
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8FOB
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![BU of 8fob by Molmil](/molmil-images/mine/8fob) | Cryo-EM structure of human TRPV6 in the open state | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CALCIUM ION, ... | 著者 | Neuberger, A, Yelshanskaya, M.V, Nadezhdin, K.D, Sobolevsky, A.I. | 登録日 | 2022-12-30 | 公開日 | 2023-05-24 | 最終更新日 | 2024-06-19 | 実験手法 | ELECTRON MICROSCOPY (2.71 Å) | 主引用文献 | Structural mechanism of human oncochannel TRPV6 inhibition by the natural phytoestrogen genistein. Nat Commun, 14, 2023
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8UC8
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![BU of 8uc8 by Molmil](/molmil-images/mine/8uc8) | HCN1 nanodisc | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2023-09-25 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 2024
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8UC7
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![BU of 8uc7 by Molmil](/molmil-images/mine/8uc7) | HCN1 complex with propofol | 分子名称: | 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,6-BIS(1-METHYLETHYL)PHENOL, Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 | 著者 | Kim, E.D, Nimigean, C.M. | 登録日 | 2023-09-25 | 公開日 | 2024-07-31 | 最終更新日 | 2024-08-14 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants. Nature, 2024
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8FPC
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![BU of 8fpc by Molmil](/molmil-images/mine/8fpc) | Conformation 1 of the ligand binding domain (LBDconf1) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | 分子名称: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.78 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FPH
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![BU of 8fph by Molmil](/molmil-images/mine/8fph) | Conformation 2 of the ligand binding domain (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100mM glutamate (Open-CaNaMg) | 分子名称: | CYCLOTHIAZIDE, GLUTAMIC ACID, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8VK3
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8FPL
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![BU of 8fpl by Molmil](/molmil-images/mine/8fpl) | LBD conformation 2 (LBDconf2) of GluA2 flip Q isoform of AMPA receptor in complex with gain-of-function TARP gamma-2, with 10mM CaCl2, 150mM NaCl, 1mM MgCl2, 330uM CTZ, and 100uM CNQX (Closed-CaNaMg) | 分子名称: | 6-(aminomethyl)-7-nitro-1,4-dihydroquinoxaline-2,3-dione, CYCLOTHIAZIDE, Glutamate receptor 2 | 著者 | Nakagawa, T. | 登録日 | 2023-01-04 | 公開日 | 2024-02-28 | 最終更新日 | 2024-05-01 | 実験手法 | ELECTRON MICROSCOPY (2.81 Å) | 主引用文献 | The open gate of the AMPA receptor forms a Ca 2+ binding site critical in regulating ion transport. Nat.Struct.Mol.Biol., 31, 2024
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8FQ8
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![BU of 8fq8 by Molmil](/molmil-images/mine/8fq8) | |