8UC7
HCN1 complex with propofol
Summary for 8UC7
Entry DOI | 10.2210/pdb8uc7/pdb |
EMDB information | 42116 42117 |
Descriptor | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1, 2,6-BIS(1-METHYLETHYL)PHENOL, 1,2-DIOLEOYL-SN-GLYCERO-3-PHOSPHOCHOLINE (3 entities in total) |
Functional Keywords | inhibitor, complex, plasma membrane, cyclic nucleotide, transport protein-inhibitor complex, transport protein/inhibitor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 4 |
Total formula weight | 308733.47 |
Authors | |
Primary citation | Kim, E.D.,Wu, X.,Lee, S.,Tibbs, G.R.,Cunningham, K.P.,Perez, M.E.,Goldstein, P.A.,Accardi, A.,Larsson, H.P.,Nimigean, C.M. Propofol rescues voltage-dependent gating of HCN1 channel epilepsy mutants Nature, 2024 Cited by DOI: 10.1038/s41586-024-07743-zPDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (2.9 Å) |
Structure validation
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