7C7J
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7CG3
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![BU of 7cg3 by Molmil](/molmil-images/mine/7cg3) | Staggered ring conformation of CtHsp104 (Hsp104 from Chaetomium Thermophilum) | 分子名称: | Heat shock protein 104 | 著者 | Inoue, Y, Hanazono, Y, Noi, K, Kawamoto, A, Kimatsuka, M, Harada, R, Takeda, K, Iwamasa, N, Shibata, K, Noguchi, K, Shigeta, Y, Namba, K, Ogura, T, Miki, K, Shinohara, K, Yohda, M. | 登録日 | 2020-06-30 | 公開日 | 2021-04-28 | 最終更新日 | 2024-05-29 | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | 主引用文献 | Split conformation of Chaetomium thermophilum Hsp104 disaggregase. Structure, 29, 2021
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8TUD
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![BU of 8tud by Molmil](/molmil-images/mine/8tud) | IgG1 Fc Heterodimer combYSelect2 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-[alpha-L-fucopyranose-(1-6)]2-acetamido-2-deoxy-beta-D-glucopyranose, Immunoglobulin gamma-1 heavy chain | 著者 | Azzam, T, Du, J.J, Sundberg, E.J. | 登録日 | 2023-08-16 | 公開日 | 2024-06-26 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Combinatorially restricted computational design of protein-protein interfaces to produce IgG heterodimers. Sci Adv, 10, 2024
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7CJG
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![BU of 7cjg by Molmil](/molmil-images/mine/7cjg) | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase | 分子名称: | 5,6-DIMETHYLBENZIMIDAZOLE, GLYCEROL, Glutamine cyclotransferase-related protein, ... | 著者 | Ruiz-Carrillo, D, Lamers, S, Feng, Q, Yu, S, Sun, B, Jiang, J, Lukman, M. | 登録日 | 2020-07-10 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase. Biol.Chem., 402, 2021
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7CB7
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![BU of 7cb7 by Molmil](/molmil-images/mine/7cb7) | 1.7A resolution structure of SARS-CoV-2 main protease (Mpro) in complex with broad-spectrum coronavirus protease inhibitor GC376 | 分子名称: | (1R,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, 3C-like proteinase, ... | 著者 | Wang, Y.C, Yang, C.S, Hou, M.H, Tsai, C.L, Chou, Y.Z, Chen, Y, Hung, M.C. | 登録日 | 2020-06-10 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. Am J Cancer Res, 10, 2020
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7CKV
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![BU of 7ckv by Molmil](/molmil-images/mine/7ckv) | Crystal structure of Cyanobacteriochrome GAF domain in Pr state | 分子名称: | MAGNESIUM ION, PHYCOCYANOBILIN, RcaE | 著者 | Nagae, T, Koizumi, T, Hirose, Y, Mishima, M. | 登録日 | 2020-07-19 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Structural basis of the protochromic green/red photocycle of the chromatic acclimation sensor RcaE. Proc.Natl.Acad.Sci.USA, 118, 2021
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7C7I
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7CHT
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![BU of 7cht by Molmil](/molmil-images/mine/7cht) | Crystal structure of TTK kinase domain in complex with compound 30 | 分子名称: | 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(oxan-4-ylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK, MAGNESIUM ION | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Ko, E.H, Choi, H.G, Son, J.B, Kim, N.D. | 登録日 | 2020-07-06 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7CKL
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![BU of 7ckl by Molmil](/molmil-images/mine/7ckl) | Structure of Lassa virus polymerase bound to Z matrix protein | 分子名称: | MANGANESE (II) ION, RING finger protein Z, RNA-directed RNA polymerase L, ... | 著者 | Xu, X, Peng, R, Peng, Q, Shi, Y. | 登録日 | 2020-07-17 | 公開日 | 2021-05-05 | 最終更新日 | 2021-11-17 | 実験手法 | ELECTRON MICROSCOPY (3.88 Å) | 主引用文献 | Cryo-EM structures of Lassa and Machupo virus polymerases complexed with cognate regulatory Z proteins identify targets for antivirals Nat Microbiol, 6, 2021
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7CJE
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![BU of 7cje by Molmil](/molmil-images/mine/7cje) | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase | 分子名称: | GLYCEROL, Glutamine cyclotransferase-related protein, MAGNESIUM ION, ... | 著者 | Ruiz-Carrillo, D, Lamers, S, Feng, Q, Yu, S, Sun, B, Jiang, J, Lukman, M. | 登録日 | 2020-07-10 | 公開日 | 2021-05-05 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.950007 Å) | 主引用文献 | Structural and kinetic characterization of Porphyromonas gingivalis glutaminyl cyclase. Biol.Chem., 402, 2021
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7C7R
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![BU of 7c7r by Molmil](/molmil-images/mine/7c7r) | Biofilm associated protein - B domain | 分子名称: | Biofilm-associated surface protein, CALCIUM ION | 著者 | Ma, J.F, Xu, Z.H, Zhang, Y.K, Cheng, X, Fan, S.L, Wang, J.W, Fang, X.Y. | 登録日 | 2020-05-26 | 公開日 | 2021-05-12 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (3.07 Å) | 主引用文献 | Structural mechanism for modulation of functional amyloid and biofilm formation by Staphylococcal Bap protein switch. Embo J., 40, 2021
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7CHM
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![BU of 7chm by Molmil](/molmil-images/mine/7chm) | Crystal structure of TTK kinase domain in complex with compound 8 | 分子名称: | 4-(cyclohexylamino)-2-[(2-methoxy-4-morpholin-4-ylcarbonyl-phenyl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | 登録日 | 2020-07-06 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7CHN
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![BU of 7chn by Molmil](/molmil-images/mine/7chn) | Crystal structure of TTK kinase domain in complex with compound 9 | 分子名称: | 4-(cyclohexylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | 登録日 | 2020-07-06 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7C3O
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![BU of 7c3o by Molmil](/molmil-images/mine/7c3o) | Crystal structure of TT109 from CANDIDA ALBICANS | 分子名称: | ACETYL COENZYME *A, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Chen, Y.P, Lei, J.H, Lu, D.R, Su, D. | 登録日 | 2020-05-13 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.89 Å) | 主引用文献 | Crystal structure of TT109 from CANDIDA ALBICANS To Be Published
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7CLH
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![BU of 7clh by Molmil](/molmil-images/mine/7clh) | Crystal structure of TTK kinase domain in complex with compound 19 | 分子名称: | 2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-4-(methylamino)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | 登録日 | 2020-07-21 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7C41
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![BU of 7c41 by Molmil](/molmil-images/mine/7c41) | KRAS G12V and H-REV107 peptide complex | 分子名称: | GTPase KRas, GUANOSINE-5'-DIPHOSPHATE, HRAS-like suppressor 3, ... | 著者 | Han, C.W, Jeong, M.S, Jang, S.B. | 登録日 | 2020-05-14 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.276 Å) | 主引用文献 | A H-REV107 Peptide Inhibits Tumor Growth and Interacts Directly with Oncogenic KRAS Mutants. Cancers (Basel), 12, 2020
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7CH7
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![BU of 7ch7 by Molmil](/molmil-images/mine/7ch7) | Cryo-EM structure of E.coli MlaFEB | 分子名称: | Lipid asymmetry maintenance ABC transporter permease subunit MlaE, Lipid asymmetry maintenance protein MlaB, Phospholipid ABC transporter ATP-binding protein MlaF | 著者 | Zhou, C, Shi, H, Huang, Y. | 登録日 | 2020-07-05 | 公開日 | 2021-05-19 | 最終更新日 | 2024-03-27 | 実験手法 | ELECTRON MICROSCOPY (3.9 Å) | 主引用文献 | Structural Insight into Phospholipid Transport by the MlaFEBD Complex from P. aeruginosa. J.Mol.Biol., 433, 2021
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7CHQ
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![BU of 7chq by Molmil](/molmil-images/mine/7chq) | AcrIE2 | 分子名称: | anti-CRISPR AcrIE2 | 著者 | Lee, S.Y, Park, H.H. | 登録日 | 2020-07-06 | 公開日 | 2021-05-19 | 最終更新日 | 2024-03-27 | 実験手法 | X-RAY DIFFRACTION (1.33 Å) | 主引用文献 | A 1.3 angstrom high-resolution crystal structure of an anti-CRISPR protein, AcrI E2. Biochem.Biophys.Res.Commun., 533, 2020
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7CJA
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![BU of 7cja by Molmil](/molmil-images/mine/7cja) | Crystal structure of TTK kinase domain in complex with compound 28 | 分子名称: | 4-(cyclopentylmethylamino)-2-[[2-methoxy-4-(2-oxidanylidenepyrrolidin-1-yl)phenyl]amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | 登録日 | 2020-07-09 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.49 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7CIL
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![BU of 7cil by Molmil](/molmil-images/mine/7cil) | Crystal structure of TTK kinase domain in complex with compound 7 | 分子名称: | 4-(cyclohexylamino)-2-[(1-methylpyrazol-4-yl)amino]-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile, Dual specificity protein kinase TTK | 著者 | Kim, H.L, Cho, H.Y, Park, Y.W, Lee, Y.H, Son, J.B, Ko, E.H, Choi, H.G, Kim, N.D. | 登録日 | 2020-07-07 | 公開日 | 2021-05-12 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | X-ray Crystal Structure-Guided Design and Optimization of 7 H -Pyrrolo[2,3- d ]pyrimidine-5-carbonitrile Scaffold as a Potent and Orally Active Monopolar Spindle 1 Inhibitor. J.Med.Chem., 64, 2021
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7C5C
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7C3Z
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7C3T
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![BU of 7c3t by Molmil](/molmil-images/mine/7c3t) | Crystal structure of NE0047 (N66Q) mutant in complex with 8-azaguanine | 分子名称: | 5-AMINO-1H-[1,2,3]TRIAZOLO[4,5-D]PYRIMIDIN-7-OL, Cytidine and deoxycytidylate deaminase zinc-binding region, ZINC ION | 著者 | Gaded, V, Bitra, A, Singh, J, Anand, R. | 登録日 | 2020-05-14 | 公開日 | 2021-05-26 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.07 Å) | 主引用文献 | Structure guided mutagenesis reveals the substrate determinants of guanine deaminase. J.Struct.Biol., 213, 2021
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7C3V
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![BU of 7c3v by Molmil](/molmil-images/mine/7c3v) | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) | 分子名称: | Alcohol dehydrogenase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | 著者 | Dai, W, Ni, Y, Xu, G, Liu, Y, Wang, Y, Zhou, J. | 登録日 | 2020-05-14 | 公開日 | 2021-05-19 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.20042944 Å) | 主引用文献 | Structure of a thermostable Alcohol dehydrogenase from Kluyveromyces polyspora(KpADH) To Be Published
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7CIN
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