7CB7
1.7A resolution structure of SARS-CoV-2 main protease (Mpro) in complex with broad-spectrum coronavirus protease inhibitor GC376
Summary for 7CB7
Entry DOI | 10.2210/pdb7cb7/pdb |
Descriptor | 3C-like proteinase, SODIUM ION, (1S,2S)-2-({N-[(benzyloxy)carbonyl]-L-leucyl}amino)-1-hydroxy-3-[(3S)-2-oxopyrrolidin-3-yl]propane-1-sulfonic acid, ... (5 entities in total) |
Functional Keywords | main protease, 3c-like proteinase, protein-inhibitor complex, gc376, viral protein |
Biological source | Severe acute respiratory syndrome coronavirus 2 (2019-nCoV) |
Total number of polymer chains | 2 |
Total formula weight | 70246.85 |
Authors | Wang, Y.C.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Chen, Y.,Hung, M.C. (deposition date: 2020-06-10, release date: 2021-05-05, Last modification date: 2023-11-29) |
Primary citation | Wang, Y.C.,Yang, W.H.,Yang, C.S.,Hou, M.H.,Tsai, C.L.,Chou, Y.Z.,Hung, M.C.,Chen, Y. Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. Am J Cancer Res, 10:2535-2545, 2020 Cited by PubMed: 32905393PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.69 Å) |
Structure validation
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