Loading
PDBj
MenuPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

7CB7

1.7A resolution structure of SARS-CoV-2 main protease (Mpro) in complex with broad-spectrum coronavirus protease inhibitor GC376

Functional Information from GO Data
ChainGOidnamespacecontents
A0008233molecular_functionpeptidase activity
A0019082biological_processviral protein processing
B0008233molecular_functionpeptidase activity
B0019082biological_processviral protein processing
Functional Information from PDB Data
site_idAC1
Number of Residues5
Detailsbinding site for residue NA A 401
ChainResidue
AGLY-2
AGLY-1
AGLY0
ASER1
AHOH745

site_idAC2
Number of Residues14
Detailsbinding site for residue K36 A 402
ChainResidue
ACYS145
AHIS163
AHIS164
AMET165
AGLU166
AHIS172
AGLN189
AB1S403
AHOH517
AHOH588
APHE140
AASN142
AGLY143
ASER144

site_idAC3
Number of Residues13
Detailsbinding site for residue B1S A 403
ChainResidue
AHIS41
APHE140
AASN142
ACYS145
AHIS163
AHIS164
AMET165
AGLU166
AHIS172
AGLN189
AK36402
AHOH517
AHOH588

site_idAC4
Number of Residues18
Detailsbinding site for Di-peptide B1S B 401 and CYS B 165
ChainResidue
BLEU27
BASN28
BHIS41
BPHE140
BASN142
BGLY143
BSER144
BGLY146
BSER147
BHIS163
BHIS164
BMET165
BGLU166
BHIS172
BGLN189
BK36402
BHOH554
BHOH666

site_idAC5
Number of Residues17
Detailsbinding site for Di-peptide K36 B 402 and CYS B 165
ChainResidue
BLEU27
BASN28
BHIS41
BPHE140
BASN142
BGLY143
BSER144
BGLY146
BSER147
BHIS163
BHIS164
BMET165
BGLU166
BHIS172
BGLN189
BB1S401
BHOH554

Functional Information from SwissProt/UniProt
site_idSWS_FT_FI1
Number of Residues2
DetailsACT_SITE: For 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000305|PubMed:32198291
ChainResidueDetails
AHIS41
BHIS41

site_idSWS_FT_FI2
Number of Residues2
DetailsACT_SITE: Nucleophile; for 3CL-PRO activity => ECO:0000255|PROSITE-ProRule:PRU00772, ECO:0000269|PubMed:32198291
ChainResidueDetails
ACYS145
BCYS145

site_idSWS_FT_FI3
Number of Residues2
DetailsSITE: Cleavage; by 3CL-PRO => ECO:0000250|UniProtKB:P0C6V3
ChainResidueDetails
AGLN306
BGLN306

223166

PDB entries from 2024-07-31

PDB statisticsPDBj update infoContact PDBjnumon