6QVW
| Solution structure of the free FOXO1 DNA binding domain | 分子名称: | Forkhead box protein O1 | 著者 | Psenakova, K, Obsil, T, Veverka, V, Obsilova, V, Kohoutova, K. | 登録日 | 2019-03-05 | 公開日 | 2019-09-04 | 最終更新日 | 2024-06-19 | 実験手法 | SOLUTION NMR | 主引用文献 | Forkhead Domains of FOXO Transcription Factors Differ in both Overall Conformation and Dynamics. Cells, 8, 2019
|
|
6R0X
| The extracellular domain of G6b-B in complex with Fab fragment and DP12 heparin oligosaccharide. | 分子名称: | 2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, Megakaryocyte and platelet inhibitory receptor G6b, antibody fab fragment heavy chain, ... | 著者 | Ogg, D.J, McMiken, H.J, Howard, T.D. | 登録日 | 2019-03-13 | 公開日 | 2019-09-04 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (3.13 Å) | 主引用文献 | Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. Elife, 8, 2019
|
|
5KKB
| Structure of mouse Golgi alpha-1,2-mannosidase IA and Man9GlcNAc2-PA complex | 分子名称: | 1,4-BUTANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 3-PYRIDINIUM-1-YLPROPANE-1-SULFONATE, ... | 著者 | Xiang, Y, Moremen, K.W. | 登録日 | 2016-06-21 | 公開日 | 2016-12-07 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (1.774 Å) | 主引用文献 | Substrate recognition and catalysis by GH47 alpha-mannosidases involved in Asn-linked glycan maturation in the mammalian secretory pathway. Proc. Natl. Acad. Sci. U.S.A., 113, 2016
|
|
5L17
| |
4NCO
| Crystal Structure of the BG505 SOSIP gp140 HIV-1 Env trimer in Complex with the Broadly Neutralizing Fab PGT122 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, BG505 SOSIP gp120, BG505 SOSIP gp41, ... | 著者 | Julien, J.-P, Stanfield, R.L, Lyumkis, D, Ward, A.B, Wilson, I.A. | 登録日 | 2013-10-24 | 公開日 | 2013-11-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (4.7 Å) | 主引用文献 | Crystal structure of a soluble cleaved HIV-1 envelope trimer. Science, 342, 2013
|
|
4NKH
| Crystal structure of SspH1 LRR domain | 分子名称: | E3 ubiquitin-protein ligase sspH1 | 著者 | Keszei, A.F.A, Xiaojing, T, Mccormick, C, Zeqiraj, E, Rohde, J.R, Tyers, M, Sicheri, F. | 登録日 | 2013-11-12 | 公開日 | 2013-12-11 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Structure of an SspH1-PKN1 Complex Reveals the Basis for Host Substrate Recognition and Mechanism of Activation for a Bacterial E3 Ubiquitin Ligase. Mol.Cell.Biol., 34, 2014
|
|
4NUF
| Crystal Structure of SHP/EID1 | 分子名称: | EID1 peptide, Maltose ABC transporter periplasmic protein, Nuclear receptor subfamily 0 group B member 2 chimeric construct, ... | 著者 | Zhi, X, Zhou, X.E, He, Y, Zechner, C, Suino-Powell, K.M, Kliewer, S.A, Melcher, K, Mangelsdorf, D.J, Xu, H.E. | 登録日 | 2013-12-03 | 公開日 | 2014-01-29 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural insights into gene repression by the orphan nuclear receptor SHP. Proc.Natl.Acad.Sci.USA, 111, 2014
|
|
8TK3
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites | 分子名称: | 6-(difluoromethyl)pyrimidin-4-ol, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3 | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) having oxidized catalytic cysteine and complexed with 6-(difluoromethyl)pyrimidin-4-ol at two allosteric sites To Be Published
|
|
8TK2
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid | 分子名称: | DI(HYDROXYETHYL)ETHER, DIMETHYL SULFOXIDE, Dual specificity protein phosphatase 3, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) binding 2-((2,4-difluorobenzyl)amino)-2-oxoacetic acid To Be Published
|
|
8TK5
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with HEPES | 分子名称: | 3,6,9,12,15,18,21-HEPTAOXATRICOSANE-1,23-DIOL, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, ... | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
|
|
8TK6
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) in apo form | 分子名称: | Dual specificity protein phosphatase 3 | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Fragment Screening Platform and Discovery of Novel Fragment Binders of the VHR Phosphatase, a Drug Target for Sepsis and Septic Shock To Be Published
|
|
5L0E
| Crystal Structure of Autotaxin and Compound 1 | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 6-(3-{2-[(2,3-dihydro-1H-inden-2-yl)amino]-7,8-dihydropyrido[4,3-d]pyrimidin-6(5H)-yl}propanoyl)-1,3-benzoxazol-2(3H)-one, CHLORIDE ION, ... | 著者 | Durbin, J.D. | 登録日 | 2016-07-27 | 公開日 | 2016-08-10 | 最終更新日 | 2020-07-29 | 実験手法 | X-RAY DIFFRACTION (3.06 Å) | 主引用文献 | Novel Autotaxin Inhibitors for the Treatment of Osteoarthritis Pain: Lead Optimization via Structure-Based Drug Design. Acs Med.Chem.Lett., 7, 2016
|
|
8TK4
| HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate | 分子名称: | Dual specificity protein phosphatase 3, PHOSPHATE ION | 著者 | Aleshin, A.E, Wu, J, Lambert, L.J, Cosford, N.D.P, Tautz, L. | 登録日 | 2023-07-25 | 公開日 | 2024-08-14 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | HUMAN VH1-RELATED DUAL-SPECIFICITY PHOSPHATASE (VHR) complexed with phosphate To Be Published
|
|
5L15
| The crystal structure of neuraminidase in complex with oseltamivir from A/Shanghai/2/2013 (H7N9) influenza virus | 分子名称: | (3R,4R,5S)-4-(acetylamino)-5-amino-3-(pentan-3-yloxy)cyclohex-1-ene-1-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | 著者 | Yang, H, Stevens, J. | 登録日 | 2016-07-28 | 公開日 | 2017-08-09 | 最終更新日 | 2023-10-04 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Drug Susceptibility Evaluation of an Influenza A(H7N9) Virus by Analyzing Recombinant Neuraminidase Proteins. J. Infect. Dis., 216, 2017
|
|
4O5N
| |
5L14
| |
4O5I
| |
4O5L
| |
8TO0
| 48-nm repeating structure of doublets from mouse sperm flagella | 分子名称: | Cilia- and flagella- associated protein 210, Cilia- and flagella-associated protein 107, Cilia- and flagella-associated protein 141, ... | 著者 | Chen, Z, Shiozak, M, Hass, K.M, Skinner, W, Zhao, S, Guo, C, Polacco, B.J, Yu, Z, Krogan, N.J, Kaake, R.M, Vale, R.D, Agard, D.A. | 登録日 | 2023-08-02 | 公開日 | 2023-11-01 | 最終更新日 | 2023-11-22 | 実験手法 | ELECTRON MICROSCOPY (7.7 Å) | 主引用文献 | De novo protein identification in mammalian sperm using in situ cryoelectron tomography and AlphaFold2 docking. Cell, 186, 2023
|
|
8TNS
| |
5JIW
| Crystal structure of Thermus aquaticus amylomaltase (GH77) in complex with a 34-meric cycloamylose | 分子名称: | 1,2-ETHANEDIOL, 4-alpha-glucanotransferase, CARBONATE ION, ... | 著者 | Roth, C, Bexten, N, Weizenmann, N, Saenger, T, Maier, T, Zimmermann, W, Straeter, N. | 登録日 | 2016-04-22 | 公開日 | 2017-01-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | 主引用文献 | Amylose recognition and ring-size determination of amylomaltase. Sci Adv, 3, 2017
|
|
7QUO
| |
6QKY
| Tryptophan synthase subunit alpha from Streptococcus pneumoniae with 3D domain swap in the core of TIM barrel | 分子名称: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, GLYCEROL, ... | 著者 | Michalska, K, Kowiel, M, Bigelow, L, Endres, M, Gilski, M, Jaskolski, M, Joachimiak, A, Center for Structural Genomics of Infectious Diseases (CSGID) | 登録日 | 2019-01-30 | 公開日 | 2019-03-27 | 最終更新日 | 2022-03-30 | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | 主引用文献 | 3D domain swapping in the TIM barrel of the alpha subunit of Streptococcus pneumoniae tryptophan synthase. Acta Crystallogr D Struct Biol, 76, 2020
|
|
5J68
| Structure of Astrotactin-2, a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Astrotactin-2, D-MYO-INOSITOL-1,4,5-TRIPHOSPHATE, ... | 著者 | Ni, T, Harlos, K, Gilbert, R.J.C. | 登録日 | 2016-04-04 | 公開日 | 2016-05-25 | 最終更新日 | 2024-01-10 | 実験手法 | X-RAY DIFFRACTION (5.221 Å) | 主引用文献 | Structure of astrotactin-2: a conserved vertebrate-specific and perforin-like membrane protein involved in neuronal development. Open Biology, 6, 2016
|
|
5JDS
| |