7QUO

FimH lectin domain in complex with oligomannose-6

Summary for 7QUO

• Entry DOI: 10.2210/pdb7quo/pdb
• Related: 7BHD
• Descriptor: FimH, alpha-D-mannopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-3)-[alpha-D-mannopyranose-(1-6)]alpha-D-mannopyranose-(1-6)]beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, NICKEL (II) ION, ... (5 entities in total)
• Functional Keywords: type-1 fimbriae, escherichia coli, fimh, adhesin, lectin, oligomannose, high-mannose, cell adhesion
• Biological source: Escherichia coli BL21(DE3)
• Total number of polymer chains: 4
• Total formula weight: 70888.70

Authors

Bouckaert, J.,Bourenkov, G.P. (deposition date: 2022-01-18, release date: 2023-02-01, Last modification date: 2024-02-14)

• Primary citation: Krammer, E.M.,Bridot, C.,Serna, S.,Echeverria, B.,Semwal, S.,Roubinet, B.,van Noort, K.,Wilbers, R.H.,Bourenkov, G.,de Ruyck, J.,Landemarre, L.,Reichardt, N.,Bouckaert, J.; Structural insights into a cooperative switch between one and two FimH bacterial adhesins binding pauci- and high-mannose type N-glycan receptors; J.Biol.Chem., 299:104627-, 2023; DOI: 10.1016/j.jbc.2023.104627

Experimental method

X-RAY DIFFRACTION (3 Å)