6R0X

The extracellular domain of G6b-B in complex with Fab fragment and DP12 heparin oligosaccharide.

Summary for 6R0X

Entry DOI	10.2210/pdb6r0x/pdb
Descriptor	antibody fab fragment heavy chain, antibody fab fragment light chain, Megakaryocyte and platelet inhibitory receptor G6b, ... (5 entities in total)
Functional Keywords	platelets, signaling, itim-receptor, g6b-b, heparin, blood clotting
Biological source	Homo sapiens More
Total number of polymer chains	6
Total formula weight	131714.53
Authors	Ogg, D.J.,McMiken, H.J.,Howard, T.D. (deposition date: 2019-03-13, release date: 2019-09-04, Last modification date: 2024-01-24)
Primary citation	Vogtle, T.,Sharma, S.,Mori, J.,Nagy, Z.,Semeniak, D.,Scandola, C.,Geer, M.J.,Smith, C.W.,Lane, J.,Pollack, S.,Lassila, R.,Jouppila, A.,Barr, A.J.,Ogg, D.J.,Howard, T.D.,McMiken, H.J.,Warwicker, J.,Geh, C.,Rowlinson, R.,Abbott, W.M.,Eckly, A.,Schulze, H.,Wright, G.J.,Mazharian, A.,Futterer, K.,Rajesh, S.,Douglas, M.R.,Senis, Y.A. Heparan sulfates are critical regulators of the inhibitory megakaryocyte-platelet receptor G6b-B. Elife, 8:-, 2019 Cited by PubMed: 31436532 DOI: 10.7554/eLife.46840 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (3.13 Å)

Structure validation