3OP5
 
 | | Human vaccinia-related kinase 1 | | 分子名称: | 1,2-ETHANEDIOL, GLYCEROL, Serine/threonine-protein kinase VRK1, ... | | 著者 | Allerston, C.K, Uttarkar, S, Savitsky, P, Elkins, J.M, Filippakopoulos, P, Krojer, T, Rellos, P, Fedorov, O, Eswaran, J, Brenner, B, Keates, T, Das, S, King, O, Chalk, R, Berridge, G, von Delft, F, Gileadi, O, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2010-08-31 | | 公開日 | 2010-09-22 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Structural characterization of human Vaccinia-Related Kinases (VRK) bound to small-molecule inhibitors identifies different P-loop conformations.
Sci Rep, 7, 2017
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1JU6
 | | Human Thymidylate Synthase Complex with dUMP and LY231514, A Pyrrolo(2,3-d)pyrimidine-based Antifolate | | 分子名称: | 2'-DEOXYURIDINE 5'-MONOPHOSPHATE, 2-{4-[2-(2-AMINO-4-OXO-4,7-DIHYDRO-3H-PYRROLO[2,3-D]PYRIMIDIN-5-YL)-ETHYL]-BENZOYLAMINO}-PENTANEDIOIC ACID, PHOSPHATE ION, ... | | 著者 | Sayre, P.H, Finer-Moore, J.S, Fritz, T.A, Biermann, D, Gates, S.B, MacKellar, W.C, Patel, V.F, Stroud, R.M. | | 登録日 | 2001-08-23 | | 公開日 | 2001-09-19 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.89 Å) | | 主引用文献 | Multi-targeted antifolates aimed at avoiding drug resistance form covalent closed inhibitory complexes with human and Escherichia coli thymidylate synthases.
J.Mol.Biol., 313, 2001
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3M11
 | | Crystal Structure of Aurora A Kinase complexed with inhibitor | | 分子名称: | 1-(4-{2-[(5,6-diphenylfuro[2,3-d]pyrimidin-4-yl)amino]ethyl}phenyl)-3-phenylurea, Serine/threonine-protein kinase 6 | | 著者 | Wu, J.S, Leou, J.S, Coumar, M.S, Hsieh, H.P, Wu, S.Y. | | 登録日 | 2010-03-03 | | 公開日 | 2011-03-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification
J.Med.Chem., 53, 2010
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1M9E
 | | X-ray crystal structure of Cyclophilin A/HIV-1 CA N-terminal domain (1-146) M-type H87A Complex. | | 分子名称: | Cyclophilin A, HIV-1 Capsid | | 著者 | Howard, B.R, Vajdos, F.F, Li, S, Sundquist, W.I, Hill, C.P. | | 登録日 | 2002-07-28 | | 公開日 | 2003-05-27 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.72 Å) | | 主引用文献 | Structural insights into the catalytic mechanism of cyclophilin A
Nat.Struct.Biol., 10, 2003
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3NMR
 | | Crystal Structure of CUGBP1 RRM1/2-RNA Complex | | 分子名称: | CUGBP Elav-like family member 1, RNA (5'-R(*GP*UP*UP*GP*UP*UP*UP*UP*GP*UP*UP*U)-3') | | 著者 | Teplova, M, Song, J, Gaw, H, Teplov, A, Patel, D.J. | | 登録日 | 2010-06-22 | | 公開日 | 2010-10-27 | | 最終更新日 | 2024-10-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural Insights into RNA Recognition by the Alternate-Splicing Regulator CUG-Binding Protein 1.
Structure, 18, 2010
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3NC1
 | | Crystal structure of the CRM1-RanGTP complex | | 分子名称: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | | 登録日 | 2010-06-04 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.35 Å) | | 主引用文献 | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nat.Struct.Mol.Biol., 17, 2010
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1LE9
 | | Crystal structure of a NF-kB heterodimer bound to the Ig/HIV-kB siti | | 分子名称: | 5'-D(*AP*AP*GP*GP*AP*AP*AP*GP*TP*CP*CP*C)-3', 5'-D(*TP*GP*GP*GP*AP*CP*TP*TP*TP*CP*CP*T)-3', NUCLEAR FACTOR NF-KAPPA-B P50 SUBUNIT, ... | | 著者 | Benjamin, B, Huang, D.B, Chen-Park, F.E, Sigler, P.B, Ghosh, G. | | 登録日 | 2002-04-09 | | 公開日 | 2003-04-15 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | The x-ray crystal structure of the NF-kappa B p50.p65 heterodimer bound to the interferon beta -kappa B site.
J.Biol.Chem., 277, 2002
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1JJR
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3NBZ
 | | Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal I) | | 分子名称: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | | 登録日 | 2010-06-04 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nat.Struct.Mol.Biol., 17, 2010
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1JM7
 | | Solution structure of the BRCA1/BARD1 RING-domain heterodimer | | 分子名称: | BRCA1-ASSOCIATED RING DOMAIN PROTEIN 1, BREAST CANCER TYPE 1 SUSCEPTIBILITY PROTEIN, ZINC ION | | 著者 | Brzovic, P.S, Rajagopal, P, Hoyt, D.W, King, M.-C, Klevit, R.E. | | 登録日 | 2001-07-17 | | 公開日 | 2001-10-03 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Structure of a BRCA1-BARD1 heterodimeric RING-RING complex.
Nat.Struct.Biol., 8, 2001
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3MXF
 | | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor JQ1 | | 分子名称: | (6S)-6-(2-tert-butoxy-2-oxoethyl)-4-(4-chlorophenyl)-2,3,9-trimethyl-6,7-dihydrothieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-10-ium, 1,2-ETHANEDIOL, Bromodomain-containing protein 4, ... | | 著者 | Filippakopoulos, P, Picaud, S, Qi, J, Keates, T, Felletar, I, Fedorov, O, Muniz, J, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Weigelt, J, Bountra, C, Bradner, J.E, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2010-05-07 | | 公開日 | 2010-10-06 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | | 主引用文献 | Selective inhibition of BET bromodomains.
Nature, 468, 2010
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1MIK
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3MYG
 | | Aurora A Kinase complexed with SCH 1473759 | | 分子名称: | 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol, Serine/threonine-protein kinase 6, TETRAETHYLENE GLYCOL | | 著者 | Hruza, A, Prosis, W, Ramanathan, L. | | 登録日 | 2010-05-10 | | 公開日 | 2010-07-21 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
ACS Med Chem Lett, 1, 2010
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3PGW
 | | Crystal structure of human U1 snRNP | | 分子名称: | DNA 5'-D(*AP*GP*GP*TP*AP*AP*GP*TP*A)-3', Sm B, Sm G, ... | | 著者 | Weber, G, Trowitzsch, S, Kastner, B, Luehrmann, R, Wahl, M.C. | | 登録日 | 2010-11-02 | | 公開日 | 2010-12-29 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (4.4 Å) | | 主引用文献 | Functional organization of the Sm core in the crystal structure of human U1 snRNP.
Embo J., 29, 2010
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1JWH
 | | Crystal Structure of Human Protein Kinase CK2 Holoenzyme | | 分子名称: | Casein kinase II beta chain, Casein kinase II, alpha chain, ... | | 著者 | Niefind, K, Guerra, B, Ermakowa, I, Issinger, O.G. | | 登録日 | 2001-09-04 | | 公開日 | 2002-03-04 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Crystal structure of human protein kinase CK2: insights into basic properties of the CK2 holoenzyme.
EMBO J., 20, 2001
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3PJA
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1JPW
 | | Crystal Structure of a Human Tcf-4 / beta-Catenin Complex | | 分子名称: | BETA-CATENIN, transcription factor 7-like 2 | | 著者 | Poy, F, Lepourcelet, M, Shivdasani, R.A, Eck, M.J. | | 登録日 | 2001-08-03 | | 公開日 | 2001-12-05 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure of a human Tcf4-beta-catenin complex.
Nat.Struct.Biol., 8, 2001
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3MXX
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3N0D
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1N41
 | | Crystal Structure of Annexin V K27E Mutant | | 分子名称: | CALCIUM ION, SULFATE ION, annexin V | | 著者 | Mo, Y.D, Campos, B, Mealy, T.R, Commodore, L, Head, J.F, Dedman, J.R, Seaton, B.A. | | 登録日 | 2002-10-30 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Interfacial basic cluster in annexin V couples phospholipid
binding and trimer formation on membrane surfaces
J.Biol.Chem., 278, 2003
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1MUO
 | | CRYSTAL STRUCTURE OF AURORA-2, AN ONCOGENIC SERINE-THREONINE KINASE | | 分子名称: | ADENOSINE, Aurora-related kinase 1 | | 著者 | Cheetham, G.M.T, Knegtel, R.M.A, Coll, J.T, Renwick, S.B, Swenson, L, Weber, P, Lippke, J.A, Austen, D.A. | | 登録日 | 2002-09-24 | | 公開日 | 2003-04-15 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Crystal Structure of Aurora-2, an Oncogenic Serine/Threonine Kinase
J.Biol.Chem., 277, 2002
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1N44
 | | Crystal Structure of Annexin V R23E Mutant | | 分子名称: | Annexin V, CALCIUM ION, SULFATE ION | | 著者 | Mo, Y.D, Campos, B, Mealy, T.R, Commodore, L, Head, J.F, Dedman, J.R, Seaton, B.A. | | 登録日 | 2002-10-30 | | 公開日 | 2003-02-04 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Interfacial basic cluster in anexin V couples phospholipid binding and trimer formation on membrane surfaces
J.Biol.Chem., 278, 2003
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3NC0
 | | Crystal structure of the HIV-1 Rev NES-CRM1-RanGTP nuclear export complex (crystal II) | | 分子名称: | DI(HYDROXYETHYL)ETHER, Exportin-1, GLYCEROL, ... | | 著者 | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | | 登録日 | 2010-06-04 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nat.Struct.Mol.Biol., 17, 2010
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3N0E
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3NBY
 | | Crystal structure of the PKI NES-CRM1-RanGTP nuclear export complex | | 分子名称: | Exportin-1, GTP-binding nuclear protein Ran, GUANOSINE-5'-TRIPHOSPHATE, ... | | 著者 | Guttler, T, Madl, T, Neumann, P, Deichsel, D, Corsini, L, Monecke, T, Ficner, R, Sattler, M, Gorlich, D. | | 登録日 | 2010-06-04 | | 公開日 | 2010-10-27 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (3.42 Å) | | 主引用文献 | NES consensus redefined by structures of PKI-type and Rev-type nuclear export signals bound to CRM1.
Nat.Struct.Mol.Biol., 17, 2010
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