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3MYG

Aurora A Kinase complexed with SCH 1473759

Summary for 3MYG
Entry DOI10.2210/pdb3myg/pdb
DescriptorSerine/threonine-protein kinase 6, TETRAETHYLENE GLYCOL, 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol, ... (4 entities in total)
Functional Keywordskinase, cell cycle, inhibitor, transferase
Biological sourceHomo sapiens (human)
Cellular locationCytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965
Total number of polymer chains1
Total formula weight32060.91
Authors
Hruza, A.,Prosis, W.,Ramanathan, L. (deposition date: 2010-05-10, release date: 2010-07-21, Last modification date: 2023-09-06)
Primary citationYu, T.,Tagat, J.R.,Kerekes, A.D.,Doll, R.J.,Zhang, Y.,Xiao, Y.,Esposite, S.,Belanger, D.B.,Curran, P.J.,Mandal, A.K.,Siddiqui, M.A.,Shih, N.Y.,Basso, A.D.,Liu, M.,Gray, K.,Tevar, S.,Jones, J.,Lee, S.,Liang, L.,Ponery, S.,Smith, E.B.,Hruza, A.,Voigt, J.,Ramanathan, L.,Prosise, W.,Hu, M.
Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core.
ACS Med Chem Lett, 1:214-218, 2010
Cited by
PubMed: 24900197
DOI: 10.1021/ml100063w
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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