3MYG
Aurora A Kinase complexed with SCH 1473759
Summary for 3MYG
Entry DOI | 10.2210/pdb3myg/pdb |
Descriptor | Serine/threonine-protein kinase 6, TETRAETHYLENE GLYCOL, 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol, ... (4 entities in total) |
Functional Keywords | kinase, cell cycle, inhibitor, transferase |
Biological source | Homo sapiens (human) |
Cellular location | Cytoplasm, cytoskeleton, microtubule organizing center, centrosome : O14965 |
Total number of polymer chains | 1 |
Total formula weight | 32060.91 |
Authors | Hruza, A.,Prosis, W.,Ramanathan, L. (deposition date: 2010-05-10, release date: 2010-07-21, Last modification date: 2023-09-06) |
Primary citation | Yu, T.,Tagat, J.R.,Kerekes, A.D.,Doll, R.J.,Zhang, Y.,Xiao, Y.,Esposite, S.,Belanger, D.B.,Curran, P.J.,Mandal, A.K.,Siddiqui, M.A.,Shih, N.Y.,Basso, A.D.,Liu, M.,Gray, K.,Tevar, S.,Jones, J.,Lee, S.,Liang, L.,Ponery, S.,Smith, E.B.,Hruza, A.,Voigt, J.,Ramanathan, L.,Prosise, W.,Hu, M. Discovery of a Potent, Injectable Inhibitor of Aurora Kinases Based on the Imidazo-[1,2-a]-Pyrazine Core. ACS Med Chem Lett, 1:214-218, 2010 Cited by PubMed: 24900197DOI: 10.1021/ml100063w PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.4 Å) |
Structure validation
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