3MYG
Aurora A Kinase complexed with SCH 1473759
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Serine/threonine-protein kinase 6 | polymer | 272 | 31440.2 | 1 | UniProt (O14965) Pfam (PF00069) | Homo sapiens (human) | Aurora kinase A, Serine/threonine-protein kinase aurora-A, Serine/threonine-protein kinase 15, Aurora/IPL1-related kinase 1, Aurora-related kinase 1, ARK-1, hARK1, Breast tumor-amplified kinase |
| 2 | B (A) | TETRAETHYLENE GLYCOL | non-polymer | 194.2 | 1 | Chemie (PG4) | |||
| 3 | C (A) | 2-{ethyl[(5-{[6-methyl-3-(1H-pyrazol-4-yl)imidazo[1,2-a]pyrazin-8-yl]amino}isothiazol-3-yl)methyl]amino}-2-methylpropan-1-ol | non-polymer | 426.5 | 1 | Chemie (EML) | |||
| 4 | D (A) | water | water | 18.0 | 47 | Chemie (HOH) |
Sequence modifications
A: 125 - 391 (UniProt: O14965)
| PDB | External Database | Details |
|---|---|---|
| Gly 120 | - | expression tag |
| Ala 121 | - | expression tag |
| Met 122 | - | expression tag |
| Gly 123 | - | expression tag |
| Ser 124 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 31440.2 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 620.8 | |
| All* | Total formula weight | 32060.9 |
