PDB: 340 件ウェブページステータス検索Chemie searchBIRD

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6UIM	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-{[(3-aminopropyl)amino]-2-oxoheptyl} thioacetate 分子名称: 7-[(3-aminopropyl)amino]-1-sulfanylheptan-2-one, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2019-10-01 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.75 Å) 主引用文献 Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UO5	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) Y363F mutant complexed with AR-42 分子名称: 1,2-ETHANEDIOL, AR-42, Histone deacetylase 6, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-10-14 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.43934226 Å) 主引用文献 Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58, 2019
6UHU	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 5-[(3-aminopropyl)amino]pentylboronic acid 分子名称: 5-(3-azanylpropylamino)pentyl-$l^{3}-oxidanyl-bis(oxidanyl)boron, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2019-09-28 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UIJ	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with S-{5-[(3-aminopropyl)amino]pentyl} thioacetate 分子名称: 5-[(3-aminopropyl)amino]pentane-1-thiol, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2019-10-01 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.9 Å) 主引用文献 Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UFO	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-[(3-aminopropyl)amino]-1-methoxyheptan-2-one 分子名称: 7-[(3-aminopropyl)amino]-1-methoxyheptane-2,2-diol, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2019-09-24 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.68 Å) 主引用文献 Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UO4	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) Y363F mutant complexed with Trichostatin A 分子名称: Histone deacetylase 6, POTASSIUM ION, TRICHOSTATIN A, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-10-14 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.26830983 Å) 主引用文献 Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58, 2019
6UIL	Crystal Structure of Danio rerio Histone Deacetylase 10 in Complex with 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one 分子名称: 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, PHOSPHATE ION, POTASSIUM ION, ... 著者 Herbst-Gervasoni, C.J, Christianson, D.W. 登録日 2019-10-01 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.85 Å) 主引用文献 Binding ofN8-Acetylspermidine Analogues to Histone Deacetylase 10 Reveals Molecular Strategies for Blocking Polyamine Deacetylation. Biochemistry, 58, 2019
6UO7	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with AR-42 分子名称: AR-42, Histone deacetylase 6, POTASSIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-10-14 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.39501321 Å) 主引用文献 Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58, 2019
6UOB	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with Resminostat 分子名称: 1,2-ETHANEDIOL, Histone deacetylase 6, PHENYLALANINE, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-10-14 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.58000576 Å) 主引用文献 Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58, 2019
6UOC	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with Givinostat 分子名称: 1,2-ETHANEDIOL, Givinostat, Histone deacetylase 6, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-10-14 公開日 2019-12-04 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.400008 Å) 主引用文献 Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58, 2019
6R0K	X-ray structure of Danio rerio histone deacetylase 6 (HDAC6) CD2 in complex with a inhibitor SS208 分子名称: 5-[2-[(3,4-dichlorophenyl)carbonylamino]ethyl]-~{N}-oxidanyl-1,2-oxazole-3-carboxamide, Histone deacetylase 6, POTASSIUM ION, ... 著者 Barinka, C, Ustinova, K, Motlova, L, Pavlicek, J. 登録日 2019-03-13 公開日 2019-10-09 最終更新日 2024-01-24 実験手法 X-RAY DIFFRACTION (1.15 Å) 主引用文献 Discovery of a New Isoxazole-3-hydroxamate-Based Histone Deacetylase 6 Inhibitor SS-208 with Antitumor Activity in Syngeneic Melanoma Mouse Models. J.Med.Chem., 62, 2019
6PHT	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 5-[(3-aminopropyl)amino]pentylboronic acid 分子名称: Acetylpolyamine amidohydrolase, MAGNESIUM ION, POTASSIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-25 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.8 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PID	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 8-amino-N-hydroxyoctanamide 分子名称: 8-amino-N-hydroxyoctanamide, Acetylpolyamine amidohydrolase, MAGNESIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-26 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.546 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PI8	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with acetate 分子名称: 1,2-ETHANEDIOL, ACETATE ION, Acetylpolyamine amidohydrolase, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-26 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.635 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PHZ	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptan-2-one 分子名称: 7-[(3-aminopropyl)amino]-1,1,1-trifluoroheptane-2,2-diol, Acetylpolyamine Amidohydrolase, MAGNESIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-25 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PIA	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide 分子名称: 1,2-ETHANEDIOL, 6-[(3-aminopropyl)amino]-N-hydroxyhexanamide, Acetylpolyamine amidohydrolase, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-26 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.75 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PHR	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 5-[(3-aminopropyl)amino]pentane-1-thiol 分子名称: 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 5-[(3-aminopropyl)amino]pentane-1-thiol, Acetylpolyamine amidohydrolase, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-25 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.65 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PI1	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 4-(dimethylamino)-N-[7-hydroxyamino)-7-oxoheptyl]benzamide 分子名称: 4-(dimethylamino)-N-[7-(hydroxyamino)-7-oxoheptyl]benzamide, Acetylpolyamine amidohydrolase, MAGNESIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-25 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6PIC	Crystal structure of Marinobacter subterrani acetylpolyamine amidohydrolase (msAPAH) complexed with 6-amino-N-hydroxyhexanamide 分子名称: 6-amino-N-hydroxyhexanamide, Acetylpolyamine Amidohydrolase, MAGNESIUM ION, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2019-06-26 公開日 2019-09-18 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (2.031 Å) 主引用文献 Structure and Function of the Acetylpolyamine Amidohydrolase from the Deep Earth HalophileMarinobacter subterrani. Biochemistry, 58, 2019
6FU1	Crystal structure of Schistosoma mansoni HDAC8 complexed with a n-alkyl hydroxamate 分子名称: GLYCEROL, Histone deacetylase, POTASSIUM ION, ... 著者 Marek, M, Shaik, T.B, Romier, C. 登録日 2018-02-26 公開日 2019-03-13 最終更新日 2024-05-08 実験手法 X-RAY DIFFRACTION (1.548 Å) 主引用文献 A Novel Class of Schistosoma mansoni Histone Deacetylase 8 (HDAC8) Inhibitors Identified by Structure-Based Virtual Screening and In Vitro Testing. Molecules, 23, 2018
5ZMP	The structure of a lysine deacylase 分子名称: ZINC ION, lysine deacylase 著者 Ge, F. 登録日 2018-04-05 公開日 2019-02-06 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.19 Å) 主引用文献 The structure of a lysine deacylase To Be Published
6GJK	A degradation product of PD 404182 (P2742) bound to Histone Deacetylase-like Amidohydrolase 分子名称: 2-(1,4,5,6-tetrahydropyrimidin-2-yl)benzenethiol, ACETATE ION, D-MALATE, ... 著者 Kraemer, A, Meyer-Almes, F.J. 登録日 2018-05-16 公開日 2019-01-16 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.47 Å) 主引用文献 Covalent inhibition of histone deacetylase 8 by 3,4-dihydro-2H-pyrimido[1,2-c][1,3]benzothiazin-6-imine. Biochim Biophys Acta Gen Subj, 1863, 2019
6FYZ	Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor 分子名称: (2~{S})-2-(2-fluorophenyl)-2-[4-(2-methylpyrimidin-5-yl)phenyl]-~{N}-oxidanyl-ethanamide, Histone deacetylase 4, SODIUM ION, ... 著者 Luckhurst, C.A, Maillard, M.C, Dominguez, C. 登録日 2018-03-13 公開日 2018-12-05 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (2.15 Å) 主引用文献 Development and characterization of a CNS-penetrant benzhydryl hydroxamic acid class IIa histone deacetylase inhibitor. Bioorg. Med. Chem. Lett., 29, 2019
6MR5	Crystal Structure of Danio rerio histone deacetylase 6 catalytic domain 2 in complex with a mercaptoacetamide-based inhibitor 分子名称: 1,2-ETHANEDIOL, CITRATE ANION, DI(HYDROXYETHYL)ETHER, ... 著者 Porter, N.J, Christianson, D.W. 登録日 2018-10-11 公開日 2018-12-05 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.85 Å) 主引用文献 Molecular Basis for the Selective Inhibition of Histone Deacetylase 6 by a Mercaptoacetamide Inhibitor. ACS Med Chem Lett, 9, 2018
6CW8	Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with RTS-V5 分子名称: 1,2-ETHANEDIOL, Hdac6 protein, N-(2,2-dimethylpropyl)-N~2~-[4-(hydroxycarbamoyl)benzene-1-carbonyl]-L-asparaginyl-N-benzyl-L-alaninamide, ... 著者 Osko, J.D, Christianson, D.W. 登録日 2018-03-30 公開日 2018-11-21 最終更新日 2023-10-04 実験手法 X-RAY DIFFRACTION (1.9 Å) 主引用文献 Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J. Med. Chem., 61, 2018

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