6UOC
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with Givinostat
Summary for 6UOC
| Entry DOI | 10.2210/pdb6uoc/pdb |
| Descriptor | Histone deacetylase 6, 1,2-ETHANEDIOL, ZINC ION, ... (6 entities in total) |
| Functional Keywords | histone deacetylase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
| Biological source | Danio rerio (Zebrafish) |
| Total number of polymer chains | 1 |
| Total formula weight | 41029.87 |
| Authors | Osko, J.D.,Christianson, D.W. (deposition date: 2019-10-14, release date: 2019-12-04, Last modification date: 2023-10-11) |
| Primary citation | Osko, J.D.,Christianson, D.W. Structural Basis of Catalysis and Inhibition of HDAC6 CD1, the Enigmatic Catalytic Domain of Histone Deacetylase 6. Biochemistry, 58:4912-4924, 2019 Cited by PubMed: 31755702DOI: 10.1021/acs.biochem.9b00934 PDB entries with the same primary citation |
| Experimental method | X-RAY DIFFRACTION (1.40000794136 Å) |
Structure validation
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