6UOC
Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 1 (CD1) K330L mutant complexed with Givinostat
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Histone deacetylase 6 | polymer | 366 | 40278.6 | 1 | UniProt (F8W4B7) Pfam (PF00850) In PDB | Danio rerio (Zebrafish) | |
2 | A | 1,2-ETHANEDIOL | non-polymer | 62.1 | 3 | Chemie (EDO) | |||
3 | A | ZINC ION | non-polymer | 65.4 | 1 | Chemie (ZN) | |||
4 | A | POTASSIUM ION | non-polymer | 39.1 | 2 | Chemie (K) | |||
5 | A | Givinostat | non-polymer | 421.5 | 1 | Chemie (QCM) | |||
6 | water | water | 18.0 | 432 | Chemie (HOH) |
Sequence modifications
A: 60 - 419 (UniProt: F8W4B7)
PDB | External Database | Details |
---|---|---|
Ser 54 | - | expression tag |
Asn 55 | - | expression tag |
Ala 56 | - | expression tag |
Gly 57 | - | expression tag |
Gly 58 | - | expression tag |
Ser 59 | - | expression tag |
Leu 330 | Lys 330 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 40278.6 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 751.3 | |
All* | Total formula weight | 41029.9 |