6CW8

Crystal structure of Danio rerio histone deacetylase 6 catalytic domain 2 complexed with RTS-V5

Summary for 6CW8

Entry DOI	10.2210/pdb6cw8/pdb
Descriptor	Hdac6 protein, ZINC ION, POTASSIUM ION, ... (6 entities in total)
Functional Keywords	histone deacetylase, metallohydrolase, hydrolase
Biological source	Danio rerio (Zebrafish)
Total number of polymer chains	2
Total formula weight	82467.98
Authors	Osko, J.D.,Christianson, D.W. (deposition date: 2018-03-30, release date: 2018-11-21, Last modification date: 2023-10-04)
Primary citation	Bhatia, S.,Krieger, V.,Groll, M.,Osko, J.D.,Ahlert, H.,Borkhardt, A.,Kurz, T.,Christianson, D.W.,Hauer, J.,Hansen, F.K. Discovery of the First-in-Class Dual Histone Deacetylase-Proteasome Inhibitor. J. Med. Chem., 61:10299-10309, 2018 Cited by PubMed: 30365892 DOI: 10.1021/acs.jmedchem.8b01487 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.9 Å)

Structure validation