PDB: 23765 件ウェブページステータス検索Chemie searchBIRD

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8RBD	Crystal structure of Mycobacterium tuberculosis MmaA1 with Sinefungin (SFG) 分子名称: 1,2-ETHANEDIOL, Mycolic acid methyltransferase MmaA1, SINEFUNGIN, ... 著者 Kobakhidze, G, Wachelder, L, Chaudhary, B, Mazumdar, P.A, Madhurantakam, C, Dong, G. 登録日 2023-12-04 公開日 2024-12-11 最終更新日 2025-06-04 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Crystal structures of the mycolic acid methyl transferase 1 (MmaA1) from Mycobacterium tuberculosis in the apo-form and in complex with different cofactors reveal unique features for substrate binding. J.Biomol.Struct.Dyn., 2025
5YHT	Crystal structure of a phosphatase from Mycobacterium tuberculosis in complex with its substrate 分子名称: Histidinol-phosphatase, L-histidinol, PHOSPHATE ION, ... 著者 Biswal, B.K, Jha, B. 登録日 2017-09-29 公開日 2018-05-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (2.87 Å) 主引用文献 Identification and structural characterization of a histidinol phosphate phosphatase fromMycobacterium tuberculosis J. Biol. Chem., 293, 2018
8RAQ	Crystal structure of Mycobacterium tuberculosis MmaA1 with S-adenosyl methionine (SAM) 分子名称: 1,2-ETHANEDIOL, GLYCEROL, Mycolic acid methyltransferase MmaA1, ... 著者 Chaudhary, B, Kobakhidze, G, Wachelder, L, Mazumdar, P.A, Madhurantakam, C, Dong, G. 登録日 2023-12-01 公開日 2024-12-11 最終更新日 2025-06-04 実験手法 X-RAY DIFFRACTION (1.4 Å) 主引用文献 Crystal structures of the mycolic acid methyl transferase 1 (MmaA1) from Mycobacterium tuberculosis in the apo-form and in complex with different cofactors reveal unique features for substrate binding. J.Biomol.Struct.Dyn., 2025
5ZON	Histidinol phosphate phosphatase from Mycobacterium tuberculosis 分子名称: GLYCEROL, Histidinol-phosphatase, PHOSPHATE ION, ... 著者 Jha, B, Kumar, D, Biswal, B.K. 登録日 2018-04-13 公開日 2018-05-23 最終更新日 2023-11-22 実験手法 X-RAY DIFFRACTION (1.94 Å) 主引用文献 Identification and structural characterization of a histidinol phosphate phosphatase from Mycobacterium tuberculosis J. Biol. Chem., 293, 2018
5UHU	Solution conformation of cytochrome P450 MycG with mycinamicin IV bound 分子名称: MYCINAMICIN IV, Mycinamicin IV hydroxylase/epoxidase, PROTOPORPHYRIN IX CONTAINING FE 著者 Pochapsky, T.C, Tietz, D.R. 登録日 2017-01-12 公開日 2017-08-23 最終更新日 2024-05-01 実験手法 SOLUTION NMR 主引用文献 Solution Conformations and Dynamics of Substrate-Bound Cytochrome P450 MycG. Biochemistry, 56, 2017
9FW3	Cryo-EM structure of IrtAB 2xEQ mutant in outward-occluded state in nanodisc in complex with mycobactin 分子名称: ADENOSINE-5'-TRIPHOSPHATE, MAGNESIUM ION, Mycobactin S, ... 著者 Gonda, I, Seeger, M.A. 登録日 2024-06-28 公開日 2024-12-18 最終更新日 2025-02-12 実験手法 ELECTRON MICROSCOPY (2.67 Å) 主引用文献 The mycobacterial ABC transporter IrtAB employs a membrane-facing crevice for siderophore-mediated iron uptake. Nat Commun, 16, 2025
2Y3R	Structure of the tirandamycin-bound FAD-dependent tirandamycin oxidase TamL in P21 space group 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. 登録日 2010-12-22 公開日 2011-06-29 最終更新日 2024-10-23 実験手法 X-RAY DIFFRACTION (1.79 Å) 主引用文献 Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
2Y3S	Structure of the tirandamycine-bound FAD-dependent tirandamycin oxidase TamL in C2 space group 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. 登録日 2010-12-23 公開日 2011-06-29 最終更新日 2024-10-09 実験手法 X-RAY DIFFRACTION (1.67 Å) 主引用文献 Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
2Y4G	Structure of the Tirandamycin-bound FAD-dependent tirandamycin oxidase TamL in P212121 space group 分子名称: CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... 著者 Carlson, J.C, Li, S, Gunatilleke, S.S, Anzai, Y, Burr, D.A, Podust, L.M, Sherman, D.H. 登録日 2011-01-05 公開日 2011-06-29 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.03 Å) 主引用文献 Tirandamycin Biosynthesis is Mediated by Co-Dependent Oxidative Enzymes Nat.Chem, 3, 2011
5I4Z	Structure of apo OmoMYC 分子名称: CHLORIDE ION, GLYCEROL, Myc proto-oncogene protein, ... 著者 Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. 登録日 2016-02-13 公開日 2016-10-26 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (1.95 Å) 主引用文献 OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, 2017
5I50	Structure of OmoMYC bound to double-stranded DNA 分子名称: DNA (5'-D(P*CP*AP*CP*CP*CP*GP*GP*TP*CP*AP*CP*GP*TP*GP*GP*CP*CP*TP*AP*CP*AP*C)-3'), DNA (5'-D(P*GP*TP*GP*TP*AP*GP*GP*CP*CP*AP*CP*GP*TP*GP*AP*CP*CP*GP*GP*GP*TP*G)-3'), Myc proto-oncogene protein 著者 Koelmel, W, Jung, L.A, Kuper, J, Eilers, M, Kisker, C. 登録日 2016-02-13 公開日 2016-10-26 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.701 Å) 主引用文献 OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors. Oncogene, 36, 2017
8HCR	Cryo-EM structure of the Mycobacterium tuberculosis cytochrome bcc:aa3 supercomplex and a novel inhibitor targeting subunit cytochrome cI 分子名称: CYTOCHROME AA3 SUBUNIT CtaC, CYTOCHROME AA3 SUBUNIT CtaJ, Cytochrome bc1 complex Rieske iron-sulfur subunit, ... 著者 Mathiyazakan, V, Gruber, G. 登録日 2022-11-02 公開日 2023-05-03 最終更新日 2025-06-25 実験手法 ELECTRON MICROSCOPY (4.5 Å) 主引用文献 Cryo-Electron Microscopy Structure of the Mycobacterium tuberculosi s Cytochrome bcc : aa 3 Supercomplex and a Novel Inhibitor Targeting Subunit Cytochrome c I. Antimicrob.Agents Chemother., 67, 2023
8FX9	Crystal strucutre of Mycobacterium tuberculosis Mycothiol-S-transferase enzyme 分子名称: CHLORIDE ION, Mycothiol-S-transferase 著者 Lindenberger, J.J, Jayasinghe, Y.P, Ronning, D.R. 登録日 2023-01-24 公開日 2023-04-05 最終更新日 2024-05-22 実験手法 X-RAY DIFFRACTION (1.36 Å) 主引用文献 The Mycobacterium tuberculosis mycothiol S -transferase is divalent metal-dependent for mycothiol binding and transfer. Rsc Med Chem, 14, 2023
6P9K	Crystal structure of Mycobacterium tuberculosis KasA in complex with O6G 分子名称: 3-oxoacyl-ACP synthase, GLYCEROL, ISOPROPYL ALCOHOL, ... 著者 Capodagli, G.C, Neiditch, M.B. 登録日 2019-06-10 公開日 2020-04-01 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.703 Å) 主引用文献 A Preclinical Candidate Targeting Mycobacterium tuberculosis KasA. Cell Chem Biol, 27, 2020
6FOC	F1-ATPase from Mycobacterium smegmatis 分子名称: ADENOSINE-5'-DIPHOSPHATE, ATP synthase epsilon chain, ATP synthase gamma chain, ... 著者 Zhang, T, Montgomery, M.G, Leslie, A.G.W, Cook, G.M, Walker, J.E. 登録日 2018-02-06 公開日 2019-01-23 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (4 Å) 主引用文献 The structure of the catalytic domain of the ATP synthase fromMycobacterium smegmatisis a target for developing antitubercular drugs. Proc.Natl.Acad.Sci.USA, 116, 2019
7AGR	Structure of the M624V-S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis soaked with MethylMalonyl Coenzyme A 分子名称: 1,2-ETHANEDIOL, Mycocerosic acid synthase 著者 Brison, Y, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-16 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
7AGS	Structure of the AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated MethylMalonyl-CoenzymeA 分子名称: METHYLMALONIC ACID, Mycocerosic acid synthase 著者 Brison, Y, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
7AGP	Structure of the AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis 分子名称: 1,2-ETHANEDIOL, Mycocerosic acid synthase 著者 Brison, Y, Nahoum, V, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-09 最終更新日 2024-10-16 実験手法 X-RAY DIFFRACTION (2.4 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
7AGQ	Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis 分子名称: ACETATE ION, GLYCEROL, Mycocerosic acid synthase 著者 Brison, Y, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-16 最終更新日 2024-11-13 実験手法 X-RAY DIFFRACTION (2.8 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
7AGT	Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated with Malonyl-coenzyme A 分子名称: MALONIC ACID, Mycocerosic acid synthase 著者 Brison, Y, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-16 最終更新日 2024-01-31 実験手法 X-RAY DIFFRACTION (2.901 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
7AGU	Structure of the S726F mutant of AcylTransferase domain of Mycocerosic Acid Synthase from Mycobacterium tuberculosis acylated with MethylMalonyl-coenzyme A 分子名称: 1,2-ETHANEDIOL, METHYLMALONIC ACID, Mycocerosic acid synthase 著者 Brison, Y, Mourey, L, Maveyraud, L. 登録日 2020-09-23 公開日 2020-12-16 最終更新日 2024-11-20 実験手法 X-RAY DIFFRACTION (3.1 Å) 主引用文献 Molecular Basis for Extender Unit Specificity of Mycobacterial Polyketide Synthases. Acs Chem.Biol., 15, 2020
6O6P	Structure of the regulator FasR from Mycobacterium tuberculosis in complex with DNA 分子名称: DNA-forward, DNA-reverse, TetR family transcriptional regulator 著者 Larrieux, N, Trajtenberg, F, Lara, J, Gramajo, H, Buschiazzo, A. 登録日 2019-03-07 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (3.851 Å) 主引用文献 Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. Nat Commun, 11, 2020
6O6O	Structure of the regulator FasR from Mycobacterium tuberculosis 分子名称: MYRISTIC ACID, TetR family transcriptional regulator 著者 Larrieux, N, Trajtenberg, F, Lara, J, Gramajo, H, Buschiazzo, A. 登録日 2019-03-07 公開日 2020-03-11 最終更新日 2023-10-11 実験手法 X-RAY DIFFRACTION (1.63 Å) 主引用文献 Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. Nat Commun, 11, 2020
6O6N	Structure of the regulator FasR from Mycobacterium tuberculosis in complex with C20-CoA 分子名称: Arachinoyl-CoA, CHLORIDE ION, TetR family transcriptional regulator 著者 Larrieux, N, Trajtenberg, F, Lara, J, Gramajo, H, Buschiazzo, A. 登録日 2019-03-07 公開日 2020-03-11 最終更新日 2024-03-13 実験手法 X-RAY DIFFRACTION (1.7 Å) 主引用文献 Mycobacterium tuberculosis FasR senses long fatty acyl-CoA through a tunnel and a hydrophobic transmission spine. Nat Commun, 11, 2020
6GEO	Crystal structure of Mycobacterium tuberculosis cytochrome P450 CYP121A1 in complex with Triazole Pyrazole inhibitor 10j 分子名称: 2-chloranyl-3-[4-(imidazol-1-ylmethyl)-1-phenyl-pyrazol-3-yl]-1~{H}-indole, Mycocyclosin synthase, PROTOPORPHYRIN IX CONTAINING FE, ... 著者 Levy, C.W. 登録日 2018-04-27 公開日 2019-08-07 最終更新日 2024-01-17 実験手法 X-RAY DIFFRACTION (1.5 Å) 主引用文献 Design and Synthesis of Imidazole and Triazole Pyrazoles asMycobacterium TuberculosisCYP121A1 Inhibitors. Chemistryopen, 8, 2019

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