Loading
PDBj
メニューPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help

5UR1
DownloadVisualize
BU of 5ur1 by Molmil
FGFR1 kinase domain complex with SN37333 in reversible binding mode
分子名称: 3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-{1-[4-(dimethylamino)but-2-enoyl]piperidin-4-yl}-7-(phenylamino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one, Fibroblast growth factor receptor 1
著者Yosaatmadja, Y, Paik, W.-K, Smaill, J.B, Squire, C.J.
登録日2017-02-09
公開日2017-05-31
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献2-Oxo-3, 4-dihydropyrimido[4, 5-d]pyrimidinyl derivatives as new irreversible pan fibroblast growth factor receptor (FGFR) inhibitors.
Eur J Med Chem, 135, 2017
6OTN
DownloadVisualize
BU of 6otn by Molmil
Crystal Structure of an N-terminal Fragment of Cancer Associated Tropomyosin 3.1 (Tpm3.1)
分子名称: SULFATE ION, Tropomyosin alpha-3 chain
著者Rynkiewicz, M.J, Ghosh, A, Lehman, W.J, Janco, M, Gunning, P.W.
登録日2019-05-03
公開日2019-08-14
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Molecular integration of the anti-tropomyosin compound ATM-3507 into the coiled coil overlap region of the cancer-associated Tpm3.1.
Sci Rep, 9, 2019
3UOT
DownloadVisualize
BU of 3uot by Molmil
Crystal Structure of MDC1 FHA Domain in Complex with a Phosphorylated Peptide from the MDC1 N-terminus
分子名称: Mediator of DNA damage checkpoint protein 1
著者Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J.
登録日2011-11-17
公開日2011-12-28
最終更新日2012-07-18
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Nucleic Acids Res., 40, 2012
3UN0
DownloadVisualize
BU of 3un0 by Molmil
Crystal Structure of MDC1 FHA Domain
分子名称: Mediator of DNA damage checkpoint protein 1, SULFATE ION
著者Clapperton, J.A, Lloyd, J, Haire, L.F, Li, J, Smerdon, S.J.
登録日2011-11-15
公開日2011-12-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator.
Nucleic Acids Res., 40, 2012
2UZ8
DownloadVisualize
BU of 2uz8 by Molmil
The crystal structure of p18, human translation elongation factor 1 epsilon 1
分子名称: EUKARYOTIC TRANSLATION ELONGATION FACTOR 1 EPSILON-1, GLYCEROL
著者Kang, B.S, Kim, K.J, Kim, M.H, Oh, Y.S, Kim, S.
登録日2007-04-26
公開日2008-03-25
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Determination of Three-Dimensional Structure and Residues of the Novel Tumor Suppressor Aimp3/P18 Required for the Interaction with Atm.
J.Biol.Chem., 283, 2008
5G55
DownloadVisualize
BU of 5g55 by Molmil
3-Quinoline Carboxamides inhibitors of Pi3K
分子名称: 6-cyano-4-[[(1R)-1-(4-methylphenyl)ethyl]amino]quinoline-3-carboxamide, PHOSPHATIDYLINOSITOL 4,5-BISPHOSPHATE 3-KINASE CATALYTIC SUBUNIT GAMMA ISOFORM, SULFATE ION
著者Edman, K, Phillips, C.
登録日2016-05-20
公開日2016-08-03
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.45 Å)
主引用文献Discovery of Novel 3-Quinoline Carboxamides as Potent, Selective and Orally Bioavailable Inhibitors of Ataxia Telangiectasia Mutated (Atm) Kinase.
J.Med.Chem., 59, 2016
4NCI
DownloadVisualize
BU of 4nci by Molmil
Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation
分子名称: DNA double-strand break repair Rad50 ATPase
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
4NCJ
DownloadVisualize
BU of 4ncj by Molmil
Crystal Structure of Pyrococcus furiosis Rad50 R805E mutation with ADP Beryllium Flouride
分子名称: ADENOSINE-5'-DIPHOSPHATE, BERYLLIUM TRIFLUORIDE ION, DNA double-strand break repair Rad50 ATPase, ...
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
4NCK
DownloadVisualize
BU of 4nck by Molmil
Crystal Structure of Pyrococcus furiosis Rad50 R797G mutation
分子名称: CHLORIDE ION, DNA double-strand break repair Rad50 ATPase, MAGNESIUM ION, ...
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
4NCH
DownloadVisualize
BU of 4nch by Molmil
Crystal Structure of Pyrococcus furiosis Rad50 L802W mutation
分子名称: DNA double-strand break repair Rad50 ATPase, SULFATE ION
著者Classen, S, Williams, G.J, Arvai, A.S, Williams, R.S.
登録日2013-10-24
公開日2014-03-05
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献ATP-driven Rad50 conformations regulate DNA tethering, end resection, and ATM checkpoint signaling.
Embo J., 33, 2014
6SKY
DownloadVisualize
BU of 6sky by Molmil
FAT and kinase domain of CtTel1
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
著者Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
登録日2019-08-16
公開日2019-10-30
最終更新日2024-05-22
実験手法ELECTRON MICROSCOPY (2.8 Å)
主引用文献Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
8HLT
DownloadVisualize
BU of 8hlt by Molmil
The co-crystal structure of DYRK2 with YK-2-99B
分子名称: (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone, Dual specificity tyrosine-phosphorylation-regulated kinase 2
著者Shen, H.T, Xiao, Y.B, Yuan, K, Yang, P, Li, Q.N.
登録日2022-12-01
公開日2023-12-13
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer.
J.Med.Chem., 66, 2023
7EJV
DownloadVisualize
BU of 7ejv by Molmil
The co-crystal structure of DYRK2 with YK-2-69
分子名称: Dual specificity tyrosine-phosphorylation-regulated kinase 2, [6-[[4-[2-(dimethylamino)-1,3-benzothiazol-6-yl]-5-fluoranyl-pyrimidin-2-yl]amino]pyridin-3-yl]-(4-ethylpiperazin-1-yl)methanone
著者Li, Z, Xiao, Y, Yuan, K, Kuang, W, Xiuquan, Y, Yang, P.
登録日2021-04-02
公開日2022-04-06
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Targeting dual-specificity tyrosine phosphorylation-regulated kinase 2 with a highly selective inhibitor for the treatment of prostate cancer.
Nat Commun, 13, 2022
6SL0
DownloadVisualize
BU of 6sl0 by Molmil
Complete CtTel1 dimer with C2 symmetry
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
著者Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
登録日2019-08-16
公開日2019-10-30
最終更新日2020-01-15
実験手法ELECTRON MICROSCOPY (3.7 Å)
主引用文献Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SL1
DownloadVisualize
BU of 6sl1 by Molmil
Structure of the open conformation of CtTel1
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
著者Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
登録日2019-08-16
公開日2019-10-30
最終更新日2020-05-13
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6SKZ
DownloadVisualize
BU of 6skz by Molmil
Structure of the closed conformation of CtTel1
分子名称: MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Tel1
著者Jansma, M, Eustermann, S.E, Kostrewa, D, Lammens, K, Hopfner, K.P.
登録日2019-08-16
公開日2019-10-30
最終更新日2020-01-15
実験手法ELECTRON MICROSCOPY (3.4 Å)
主引用文献Near-Complete Structure and Model of Tel1ATM from Chaetomium thermophilum Reveals a Robust Autoinhibited ATP State.
Structure, 28, 2020
6UVQ
DownloadVisualize
BU of 6uvq by Molmil
Crystal structure of Apo AtmM
分子名称: ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION
著者Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N.
登録日2019-11-04
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structure of Apo AtmM
To Be Published
6UWD
DownloadVisualize
BU of 6uwd by Molmil
Crystal structure of Apo AtmM
分子名称: ACETATE ION, D-glucose O-methyltransferase, MAGNESIUM ION
著者Alvarado, S.K, Wang, Z, Miller, M.D, Thorson, J.S, Phillips Jr, G.N.
登録日2019-11-05
公開日2020-11-25
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.04 Å)
主引用文献Structure of Apo AtmM
To Be Published
5FKJ
DownloadVisualize
BU of 5fkj by Molmil
Crystal structure of mouse acetylcholinesterase in complex with C-547, an alkyl ammonium derivative of 6-methyl uracil
分子名称: 1,3-BIS[5(DIETHYL-O-NITROBENZYLAMMONIUM)PENTYL]-6-METHYLURACIL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETYLCHOLINESTERASE, ...
著者Nachon, F, Villard-Wandhammer, M, Petrov, K, Masson, P.
登録日2015-10-16
公開日2016-03-16
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.133 Å)
主引用文献Slow-Binding Inhibition of Acetylcholinesterase by a 6-Methyluracil Alkyl-Ammonium Derivative: Mechanism and Advantages for Myasthenia Gravis Treatment.
Biochem.J., 473, 2016
6EHA
DownloadVisualize
BU of 6eha by Molmil
Heme oxygenase 1 in complex with inhibitor
分子名称: 1-(3-imidazol-1-ylpropyl)-5-(2-methylpropyl)-4-phenyl-imidazole, Heme oxygenase 1, PROTOPORPHYRIN IX CONTAINING FE
著者Grudnik, P, Mieczkowski, M.
登録日2017-09-12
公開日2018-10-10
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Development and characterization of a new inhibitor of heme oxygenase activity for cancer treatment.
Arch.Biochem.Biophys., 671, 2019
7X3M
DownloadVisualize
BU of 7x3m by Molmil
Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07045
分子名称: (2~{R})-2-[4-[3,5-bis(chloranyl)phenyl]-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H.
登録日2022-03-01
公開日2023-03-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (2.694 Å)
主引用文献Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
7X3L
DownloadVisualize
BU of 7x3l by Molmil
Crystal structure of Aldo-keto reductase 1C3 complexed with compound S07044
分子名称: (2~{R})-2-[4-(3-fluoranyl-4-methyl-phenyl)-3-(trifluoromethyl)phenyl]butanoic acid, Aldo-keto reductase family 1 member C3, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Jiang, J, Liu, Y, He, S, Chen, Y, Chu, X, Liu, Y, Guo, Q, Zhao, L, Feng, F, Liu, W, Zhang, X, Fang, P, Sun, H.
登録日2022-03-01
公開日2023-03-08
最終更新日2023-11-29
実験手法X-RAY DIFFRACTION (1.86 Å)
主引用文献Development of Biaryl-Containing Aldo-Keto Reductase 1C3 (AKR1C3) Inhibitors for Reversing AKR1C3-Mediated Drug Resistance in Cancer Treatment.
J.Med.Chem., 66, 2023
4W1O
DownloadVisualize
BU of 4w1o by Molmil
PDE4D complexed with inhibitor
分子名称: N-(3,5-dichloropyridin-4-yl)-3-[(3-ethyl-1,2-oxazol-5-yl)methoxy]-4-methoxybenzamide, ZINC ION, cAMP-specific 3',5'-cyclic phosphodiesterase 4D
著者Sorensen, M.D.
登録日2014-08-14
公開日2014-11-05
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery and Early Clinical Development of 2-{6-[2-(3,5-Dichloro-4-pyridyl)acetyl]-2,3-dimethoxyphenoxy}-N-propylacetamide (LEO 29102), a Soft-Drug Inhibitor of Phosphodiesterase 4 for Topical Treatment of Atopic Dermatitis
J.Med.Chem, 57, 2014
6B7U
DownloadVisualize
BU of 6b7u by Molmil
Structure of hen egg-white lysozyme without high-pressure pre-treatment
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Morais, M.A.B, Nascimento, A.F.Z, Tominaga, C.Y, Cristianini, M, Tribst, A.A.L, Murakami, M.T.
登録日2017-10-05
公開日2018-07-25
実験手法X-RAY DIFFRACTION (1.581 Å)
主引用文献How high pressure pre-treatments affect the function and structure of hen egg-white lysozyme
Innov Food Sci Emerg Technol, 47, 2018
9BLG
DownloadVisualize
BU of 9blg by Molmil
Crystal structure of non-receptor protein tyrosine phosphatase SHP2 in complex with PF-07284892
分子名称: (1S)-1'-{6-[(2-amino-3-chloropyridin-4-yl)sulfanyl]-1,2,4-triazin-3-yl}-1,3-dihydrospiro[indene-2,4'-piperidin]-1-amine, Tyrosine-protein phosphatase non-receptor type 11
著者Bester, S.M, Wu, W.-I, Mou, T.-C.
登録日2024-04-30
公開日2024-05-29
実験手法X-RAY DIFFRACTION (2.06 Å)
主引用文献SHP2 Inhibition Sensitizes Diverse Oncogene-Addicted Solid Tumors to Re-treatment with Targeted Therapy.
Cancer Discov, 13, 2023

222415

件を2024-07-10に公開中

PDB statisticsPDBj update infoContact PDBjnumon