8HLT

The co-crystal structure of DYRK2 with YK-2-99B

Summary for 8HLT

Entry DOI	10.2210/pdb8hlt/pdb
Descriptor	Dual specificity tyrosine-phosphorylation-regulated kinase 2, (6-{[(4P)-4-(1,3-benzothiazol-5-yl)-5-fluoropyrimidin-2-yl]amino}pyridin-3-yl)(piperazin-1-yl)methanone (2 entities in total)
Functional Keywords	inhibitor, cell cycle
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	91387.48
Authors	Shen, H.T.,Xiao, Y.B.,Yuan, K.,Yang, P.,Li, Q.N. (deposition date: 2022-12-01, release date: 2023-12-13)
Primary citation	Yuan, K.,Shen, H.,Zheng, M.,Xia, F.,Li, Q.,Chen, W.,Ji, M.,Yang, H.,Zhuang, X.,Cai, Z.,Min, W.,Wang, X.,Xiao, Y.,Yang, P. Discovery of Potent DYRK2 Inhibitors with High Selectivity, Great Solubility, and Excellent Safety Properties for the Treatment of Prostate Cancer. J.Med.Chem., 66:4215-4230, 2023 Cited by PubMed: 36800260 DOI: 10.1021/acs.jmedchem.3c00106 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation